Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury.

Intimal hyperplasia (IH) remains a significant clinical problem, causing vascular intervention failure. This study aimed to elucidate whether gangliosides GA2 accumulated in atherosclerotic mouse aortae and plasma promote the development of IH. We identified that GA2 was remarkably accumulated in both artery and plasma of atherosclerotic patients and mice.

Protective effects of docosahexaenoic acid combined with bilberry extract on myopic Guinea pigs.

This study aims to investigate the protective effects of docosahexaenoic acid (DHA) combined with bilberry extract (BE) on myopic guinea pigs. In total, 105 healthy pigmented guinea pigs aged 2 weeks were selected and randomly divided into five groups. The normal control (NC) group received no treatment, while the experimental groups wore -6.

Study on the determination method of excitation load in electrical signal simulation for piezoelectric ultrasonic internal inspection of pipelines.

Accurately determining the initial acoustic field excitation load of a piezoelectric ultrasonic probe is essential for simulating electrical signals and calculating wall thickness during ultrasonic internal inspection of pipelines. A new method for determining the initial excitation load of the acoustic field is proposed, incorporating the focusing effect of the curved surface of pipelines on the ultrasonic signal from the piezoelectric ultrasonic probe. Finite element models were established for the new and old methods using COMSOL software, facilitating the analysis of the initial acoustic field distribution and associated electrical signal characteristics.

Q11, a CYP2E1 inhibitor, exerts anti-hepatocellular carcinoma effect by inhibiting M2 macrophage polarization.

Despite significant advancements in cancer immunotherapy, many patients continue to respond poorly. Novel therapeutic strategies and drugs are urgently needed. Here, we found that CYP2E1 is upregulated in M2 macrophages.

Ultra-fast [F]florbetapir PET imaging using the uMI Panorama PET/CT system.

Background: There is a need for faster amyloid PET scans to reduce patients' discomfort, minimize movement artifacts, and increase throughput. The recently introduced uMI Panorama PET/CT system featuring enhanced spatial resolution and sub-200ps TOF offers the potential for shorter scan duration without sacrificing image quality or efficacy to detect Aβ deposition. The study aims to establish a faster acquisition protocol for [F]florbetapir PET imaging using digital PET/CT scanner uMI Panorama, while ensuring adequate image quality and amyloid-β (Aβ) detectability comparable to the standard 10-minute scan.