Machine Learning-based Cluster Analysis Identifies Three Unique Phenotypes of Patients With Adult Spinal Deformity With Distinct Clinical Profiles and Long-term Recovery Trajectory: A Development Study.

Study Design: A retrospective review of a prospective adult spinal deformity data.

Objective: To identify distinct patient clinical profiles and recovery trajectories in patients with adult spinal deformity (ASD).

Summary Of Background Data: Patients with ASD exhibit a diverse array of symptoms and significant heterogeneity in clinical presentations, posing challenges to precise clinical decision-making.

Digitized thermo-responsive shape memory matrix band for tooth restorations.

Direct resin restoration has been widely used to restore the tooth defect for its convenience and minimal invasion. However, the accuracy of the final contour of class II restoration is often unpredictable and quite technique-sensitive due to the limitation of traditional matrix band system. In this study, the authors developed a novel matrix band system using shape memory polymer (SMP), which possessed two reversible shapes including digitized permanent shape to reproduce anatomical proximal contour and programmable temporary shape for clinical practice and reservation.

Fluopyram analogues containing an indole moiety: synthesis, biological activity and molecular docking study.

Succinate dehydrogenase (SDH) has been identified as one of the ideal targets for the development of novel nematicides. However, the resistance of nematodes to fluopyram, one of the commercialized SDH inhibitors, is becoming a growing concern. Since expanding the structural diversity around an active scaffold is a useful strategy for drug development, herein a series of fluopyram analogues with a broad, biologically relevant indole moiety were synthesized and evaluated for nematicidal activity against C.

L-ICG as an optical agent to improve intraoperative margin detection in breast-conserving surgery: a prospective study.

Purpose: Precise tumor excision is important in breast-conserving surgery (BCS). This study explores the safety and accuracy of fluorescence image-guided BCS (FIGS) using a lidocaine mucilage-ICG compound (L-ICG).

Methods: 54 patients who underwent BCS from August 2020 to September 2023 were enrolled.

Genomic and Methylomic Signatures Associated With the Maintenance of Genome Stability and Adaptive Evolution in Two Closely Allied Wolf Spiders.

Pardosa spiders, belonging to the wolf spider family Lycosidae, play a vital role in maintaining the health of forest and agricultural ecosystems due to their function in pest control. This study presents chromosome-level genome assemblies for two allied Pardosa species, P. laura and P.