Ultrasound-Targeted β-Catenin Gene Therapy Improves the Cardiac Function in Mice After Myocardial Infarction.

Gene therapy has received great attention as a therapeutic approach to improve cardiac function post-myocardial infarction (MI), but its limitation lies in the lack of targeting. This study explored the use of ultrasound-targeted microbubble destruction (UTMD) technique to deliver β-catenin gene to the myocardium, aiming to evaluate its efficacy in preventing cardiac dysfunction post-MI. A cationic microbubble solution containing β-catenin gene pcDNA3.

Association between school bullying type and the risk of eating disorders among Chinese college students: the mediating role of body dissatisfaction.

Background: The link between school bullying and eating disorders is a complex issue that is poorly understood globally, and is further complicated by the distinct cultural nuances within China. This study aims to fill this gap by investigating the association between different types of bullying and the risk of eating disorders among college students in Shantou City, China. Additionally, this study explores the mediating role of body dissatisfaction in the relationships between bullying roles and the risk of eating disorders.

Anti irradiation nanoparticles shelter immune organ from radio-damage via preventing the IKK/IκB/NF-κB activation.

Background: Normal tissue and immune organ protection are critical parts of the tumor radiation therapy process. Radiation-induced immune organ damage (RIOD) causes several side reactions by increasing oxidative stress and inflammatory responses, resulting in unsatisfactory curability in tumor radiation therapy. The aim of this study was to develop a novel and efficient anti irradiation nanoparticle and explore its mechanism of protecting splenic tissue from radiation in mice.

Inositol 1,4,5-Trisphosphate Receptors Regulate Vascular Smooth Muscle Cell Proliferation and Neointima Formation in Mice.

Background: Vascular smooth muscle cell (VSMC) proliferation is involved in many types of arterial diseases, including neointima hyperplasia, in which Ca has been recognized as a key player. However, the physiological role of Ca release via inositol 1,4,5-trisphosphate receptors (IPRs) from endoplasmic reticulum in regulating VSMC proliferation has not been well determined.

Methods And Results: Both in vitro cell culture models and in vivo mouse models were generated to investigate the role of IPRs in regulating VSMC proliferation.

Association between organophosphorus insecticides exposure and osteoarthritis in patients with arteriosclerotic cardiovascular disease.

Background: Organic phosphorus insecticides (OPPs) are a class of environmental pollutants widely used worldwide with potential human health risks. We aimed to assess the association between exposure to OPPs and osteoarthritis (OA) particularly in participants with atherosclerotic cardiovascular disease (ASCVD).

Methods: Participants' information was obtained from data in the National Health and Nutrition Examination (NHANES).