Publications by authors named "Q D Gunst"
Article Synopsis
- * Large-scale initiatives have emerged over the last decade, relying on biobanks for high-quality images and tissue samples to further investigate human development.
- * The paper discusses the establishment of the Dutch Fetal Biobank, covering its framework, legal and ethical considerations, and initial findings from 329 tissue specimens.
Previously, we reported a series of families presenting with trichodiscomas, inherited in an autosomal dominant pattern. The phenotype was named familial multiple discoid fibromas (FMDF). The genetic cause of FMDF remained unknown so far.
View Article and Find Full Text PDFDiffusible iodine-based contrast-enhanced computed tomography (diceCT) is progressively used in clinical and morphological research to study developmental anatomy. Lugol's solution (Lugol) has gained interest as an effective contrast agent; however, usage is limited due to extensive soft-tissue shrinkage. The mechanism of Lugol-induced shrinkage and how to prevent it is largely unknown, hampering applications of Lugol in clinical or forensic cases where tissue shrinkage can lead to erroneous diagnostic conclusions.
View Article and Find Full Text PDFBackground: Quantitative PCR (qPCR) aims to measure the DNA or RNA concentration in diagnostic and biological samples based on the quantification cycle (Cq) value observed in the amplification curves. Results of qPCR experiments are regularly calculated as if all assays are 100% efficient or reported as just Cq, ΔCq, or ΔΔCq values.
Contents: When the reaction shows specific amplification, it should be deemed to be positive, regardless of the observed Cq.