St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo.

Drug resistance of cancers remains a major obstacle due to limited therapeutics. Lysosome targeting is an effective method for overcoming drug resistance in cancer cells. St-N (ent-13-hydroxy-15-kaurene-19-acid N-methylpiperazine ethyl ester) is a novel alkaline stevioside derivative with an amine group.

Synthesis of Sulfenamides via Photoredox N-S Coupling of Dialkyl Azodicarboxylates and Thiols.

We herein report a photoredox N-S coupling reaction between dialkyl azodicarboxylates and thiols to access sulfenamide scaffolds. This reaction proceeds under mild, green, and operationally simple conditions, offering a broad scope of sulfenamides with high yields and excellent atom efficiency. Mechanistic investigations revealed this reaction followed a photoinitiated radical pathway in which iodide plays a crucial role as both a radical initiator and a single-electron reductant.

Global trends and hotspots in robotic surgery over the past decade: a bibliometric and visualized analysis.

Since its introduction, robotic surgery has experienced rapid development and has been extensively implemented across various medical disciplines. It is crucial to comprehend the advancements in research and the evolutionary trajectory of its thematic priorities. This research conducted a bibliometric analysis on the literature pertaining to robotic surgery, spanning the period from 2014 to 2023, sourced from the Web of Science database.

Epidemiology and Molecular Characterization of spp. in Non-Human Primates in Zoos in China.

The genus infects both humans and NHPs. In zoos, visitors feeding significantly increases the frequency of human-to-NHP contact, thereby raising the risk of zoonotic transmission. In this study, six species were investigated and analyzed in the fecal samples of 14 NHP species from zoos in Beijing, Guiyang, Shijiazhuang, Tangshan, and Xingtai in China.