Publications by authors named "Pyatchanina T"
Unlabelled: The changes in the quantitative parameters and spatial structure of collagen are considered a key diagnostic and prognostic factor associated with the development of many malignant neoplasms, including breast cancer (BCa). The aim of the work was to develop and test an algorithm for the assessment of collagen organization parameters as informative attributes associated with BCa for developing technology of machine learning and building an intelligent system of cancer diagnostics.
Materials And Methods: Tumor tissue samples of 5 patients with breast fibroadenomas and 20 patients with stage I-II BCa were studied.
The main findings in the field of breast cancer proteomic research as well as modern strategies, technologies and methods of validation are reviewed. A special attention is focused on validated proteomic biomarkers of breast cancer. The data on proteomic profiling of stroma, tumor microenvironment, involvement of proteins in tumor progression, invasion and metastasis, and mechanisms of action of new generation drugs, are analyzed.
View Article and Find Full Text PDFAim: to study the activity of antioxidant enzymes and to evaluate an intensity of prooxidant processes in sarcoma 37 (S37) cells during tumor development and under influence of sodium dichloroacetate (SDA).
Methods: Activity of total superoxide dismutase (SOD), SOD isoforms, catalase (Cat), glutathione peroxidase (GP), and glutathione reductase (GR), as well as content of reduced glutathione (GSH) and lipid peroxidation (LP) secondary byproducts were determined in S37 homogenated tissues of untreated mice and animals treated with SDA at daily dose of 86 mg/kg.
Results: SDA treatment of S37-bearing mice resulted in the reduced activities of total SOD, SOD isoforms (especially Mn-SOD), Cat, GP and significantly decreased GSH content on the background of LP intensification in tumor tissue.
Aim: To study the functional activity of enzymatic component of antioxidant system and to evaluate an intensity of prooxidative processes in Lewis lung carcinoma variants (LLC and LLC/R9).
Methods: Activity of glutathione-S-transferase (GST), glutathione peroxidase (GP), glutathione reductase (GR), catаlase (Cat), content of lipid peroxidation (LP) byproducts were analyzed in tumor extracts at the 24(th) day after tumor transplantation, extracts of muscle tissues of tumor-bearing mice and intact mice using the method of optic spectrometry.
Results: It was revealed higher level of GST and GR activities, and lower level of GP activity, and a tendency for decrease of Cat activity level in LLC/R9 tumors compared to LLC tumors.