Publications by authors named "Pyare Lal Sangwan"
Article Synopsis
- A phytochemical analysis of Prangos pabularia root extracts revealed twelve cytotoxic compounds, identified through spectral techniques, including notable ones like osthol and xanthotoxin.
- Cytotoxicity testing using the MTT assay showed osthol had the strongest effect against various human cancer cell lines, particularly against epidermoid carcinoma A431 and lung A549 cells.
- A reliable HPLC method was developed for quantifying these compounds in the extracts, proving efficient for quality control and future pharmaceutical applications of Prangos pabularia.
Quantitative structure activity relationship (QSAR) analysis of piperine analogs as inhibitors of efflux pump NorA from Staphylococcus aureus has been performed in order to obtain a highly accurate model enabling prediction of inhibition of S. aureus NorA of new chemical entities from natural sources as well as synthetic ones. Algorithm based on genetic function approximation method of variable selection in Cerius2 was used to generate the model.
View Article and Find Full Text PDFObjectives: Evaluation of novel synthetic analogues of piperine as inhibitors of multidrug efflux pump NorA of Staphylococcus aureus.
Methods: A library of piperine-derived compounds was evaluated for their potential to inhibit ethidium bromide efflux in NorA-overexpressing S. aureus SA 1199B.