Selective social interactions and speed-induced leadership in schooling fish.

Animals moving together in groups are believed to interact among each other with effective social forces, such as attraction, repulsion, and alignment. Such forces can be inferred using "force maps," i.e.

Economic impact of inflammatory bowel disease in Catalonia: a population-based analysis.

Background: Inflammatory bowel disease (IBD) has a major economic impact on healthcare costs.

Objectives: The aim of this study was to evaluate the current healthcare expenditure associated with IBD in a population-wide study in Catalonia.

Design: Retrospective observational study.

Unpacking the modeling process for energy policy making.

This article explores how the modeling of energy systems may lead to an undue closure of alternatives by generating an excess of certainty around some of the possible policy options. We retrospectively exemplify the problem with the case of the International Institute for Applied Systems Analysis (IIASA) global modeling in the 1980s. We discuss different methodologies for quality assessment that may help mitigate this issue, which include Numeral Unit Spread Assessment Pedigree (NUSAP), diagnostic diagrams, and sensitivity auditing (SAUD).

Incidence of Myelotoxicity and Other Adverse Effects Related to Thiopurine Starting in Patients with Inflammatory Bowel Disease: Retrospective Observational Study in a Third-Level Hospital.

Background And Objectives: Thiopurines are an effective treatment for the maintenance of remission in inflammatory bowel disease (IBD). They can present adverse effects (AEs), with myelotoxicity being the most relevant. This study aims to determine the incidence of AEs related to the starting of thiopurines in our centre.

What can mathematical modelling contribute to a sociology of quantification?

Sociology of quantification has spent relatively less energies investigating mathematical modelling than it has on other forms of quantification such as statistics, metrics, or algorithms based on artificial intelligence. Here we investigate whether concepts and approaches from mathematical modelling can provide sociology of quantification with nuanced tools to ensure the methodological soundness, normative adequacy and fairness of numbers. We suggest that methodological adequacy can be upheld by techniques in the field of sensitivity analysis, while normative adequacy and fairness are targeted by the different dimensions of sensitivity auditing.

The Challenge of Quantification: An Interdisciplinary Reading.

The present work looks at what we call "the multiverse of quantification", where visible and invisible numbers permeate all aspects and venues of life. We review the contributions of different authors who focus on the roles of quantification in society, with the aim of capturing different and sometimes separate voices. Several scholars, including economists, jurists, philosophers, sociologists, communication and data scientists, express concerns or identify critical areas of our relationship with new technologies of 'numericization'.

Models with higher effective dimensions tend to produce more uncertain estimates.

Mathematical models are getting increasingly detailed to better predict phenomena or gain more accurate insights into the dynamics of a system of interest, even when there are no validation or training data available. Here, we show through ANOVA and statistical theory that this practice promotes fuzzier estimates because it generally increases the model's effective dimensions, i.e.

Scale-free behavioral cascades and effective leadership in schooling fish.

Behavioral contagion and the presence of behavioral cascades are natural features in groups of animals showing collective motion, such as schooling fish or grazing herbivores. Here we study empirical behavioral cascades observed in fish schools defined as avalanches of consecutive large changes in the heading direction of the trajectory of fish. In terms of a minimum turning angle introduced to define a large change, avalanches are characterized by distributions of size and duration showing scale-free signatures, reminiscent of self-organized critical behavior.

The delusive accuracy of global irrigation water withdrawal estimates.

Miscalculating the volumes of water withdrawn for irrigation, the largest consumer of freshwater in the world, jeopardizes sustainable water management. Hydrological models quantify water withdrawals, but their estimates are unduly precise. Model imperfections need to be appreciated to avoid policy misjudgements.

Heterogeneity in pharmacological treatment and outcomes in Crohn's disease patients in Catalonia: a population-based observational study.

Background: Heterogeneity in the treatment of a disease is a marker of suboptimal quality of care. The aim of this study is to evaluate the heterogeneity in the treatment used and the outcomes for Crohn's disease (CD) in Catalonia.

Methods: All patients with CD included in the Catalan Health Surveillance System (data on more than seven million individuals from 2011 to 2017) were identified.

Improving the reliability of cohesion policy databases.

In this contribution, we present an innovative data-driven model to reconstruct a reliable temporal pattern for time-lagged statistical monetary figures. Our research cuts across several domains regarding the production of robust economic inferences and the bridging of top-down aggregated information from central databases with disaggregated information obtained from local sources or national statistical offices. Our test bed case study is the European Regional Development Fund (ERDF).

Irrigated areas drive irrigation water withdrawals.

A sustainable management of global freshwater resources requires reliable estimates of the water demanded by irrigated agriculture. This has been attempted by the Food and Agriculture Organization (FAO) through country surveys and censuses, or through Global Models, which compute irrigation water withdrawals with sub-models on crop types and calendars, evapotranspiration, irrigation efficiencies, weather data and irrigated areas, among others. Here we demonstrate that these strategies err on the side of excess complexity, as the values reported by FAO and outputted by Global Models are largely conditioned by irrigated areas and their uncertainty.

Detection of sand encroachment patterns in desert oases. The case of Erg Chebbi (Morocco).

Desert oases are fragile agrarian areas, very vulnerable to sand encroachment by wind. Ensuring their conservation highly depends on our capacity to identify sand encroachment patterns, e.g.

Irrigated areas grow faster than the population.

Unfolding regularities between population and irrigated agriculture might increase our capacity to predict their coevolution and better ensure food security and environmental welfare. Here I use three different data sets with detailed information at the national level for ~70% of the countries of Africa, Asia, the Americas, and Europe between 1950 and 2017 to show that irrigated areas might grow disproportionally for a given increase in population, e.g.

Size and stochasticity in irrigated social-ecological systems.

This paper presents a systematic study of the relation between the size of irrigation systems and the management of uncertainty. We specifically focus on studying, through a stylized theoretical model, how stochasticity in water availability and taxation interacts with the stochastic behavior of the population within irrigation systems. Our results indicate the existence of two key population thresholds for the sustainability of any irrigation system: or the critical population size required to keep the irrigation system operative, and N* or the population threshold at which the incentive to work inside the irrigation system equals the incentives to work elsewhere.

Drip irrigation uptake in traditional irrigated fields: The edaphological impact.

Historical and traditional flood-irrigated (FI) schemes are progressively being upgraded by means of drip irrigation (DI) to tackle current water and demographic challenges. This modernization process is likely to foster several changes of environmental relevance at the system level. In this paper we assess the effects derived from DI uptake on soil health and structure in ancient FI systems through the case study of Ricote, SE Spain, first established in the 10-13th centuries CE.

New insights into replication origin characteristics in metazoans.

We recently reported the identification and characterization of DNA replication origins (Oris) in metazoan cell lines. Here, we describe additional bioinformatic analyses showing that the previously identified GC-rich sequence elements form origin G-rich repeated elements (OGREs) that are present in 67% to 90% of the DNA replication origins from Drosophila to human cells, respectively. Our analyses also show that initiation of DNA synthesis takes place precisely at 160 bp (Drosophila) and 280 bp (mouse) from the OGRE.

Synergic reprogramming of mammalian cells by combined exposure to mitotic Xenopus egg extracts and transcription factors.

Transfer of somatic cell nuclei to enucleated eggs and ectopic expression of specific transcription factors are two different reprogramming strategies used to generate pluripotent cells from differentiated cells. However, these methods are poorly efficient, and other unknown factors might be required to increase their success rate. Here we show that Xenopus egg extracts at the metaphase stage (M phase) have a strong reprogramming activity on mouse embryonic fibroblasts (MEFs).

Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features.

In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle. Their genomic organization and their genetic nature remain elusive. Here, we characterized Oris by nascent strand (NS) purification and a genome-wide analysis in Drosophila and mouse cells.

[Disorders affecting the emotional sphere and impulse control in Parkinson's disease].

Introduction: Parkinson's disease (PD) is associated with mood and behavioral symptoms contributing to morbidity and reduced quality of life of the patients. Most characteristic are depression, anxiety and impulse control disorder.

Development: Identification and treatment of neuropsychiatric symptoms is necessary for an appropriate management of PD.

[How to identify adverse events in emergency services? A guide agreed for the screening].

Objective: Since a third of adverse events (AE) occur outside hospital, the Emergency Services are a suitable place to look at their incidence. We considered designing a screening guide, adapted to the conditions of the emergency services, to identify AE.

Material And Methods: A qualitative technique was applied (nominal group) in which 14 professionals participated.