Adipocyte-specific deletion of PIP5K1c reduces diet-induced obesity and insulin resistance by increasing energy expenditure.

Background: Phosphatidylinositol 4-phosphate 5-kinase type I c (PIP5K1c) catalyses the synthesis of phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) by phosphorylating phosphatidylinositol 4 phosphate, which plays multiple roles in regulating focal adhesion formation, invasion, and cell migration signal transduction cascades. Here, a new physiological mechanism of PIP5K1c in adipocytes and systemic metabolism is reported.

Methods: Adipose-specific conditional knockout mice were generated to delete the PIP5K1c gene in adipocytes.

A fractal analysis of radon migration in discrete fracture network model.

A novel model is proposed to simulate radon migration by combining the fractal theory and the discrete fracture network (DFN) model. In the model, a power-law distribution based on fractal theory is applied to fracture length and aperture and the fracture locations and orientations are modeled with the Poisson distribution and von Mises-Fisher distribution, respectively. The model was applied to produce a computer code that can calculate the radon concentration, flux, and diffusivity of the fractured media.

Heat-air-moisture coupled model for radon migration in a porous media.

Radon is one of the main causes of environmental pollution and lung cancer. The precipitation of radon from porous media is affected by the coupling of heat and moisture, which has not been considered in the existing knowledge. We present a model for predicting radon migration in porous media.