Association between adolescent obesity and early adulthood healthcare utilization-a two-cohort prospective study.

Background: Pediatric obesity is a growing global health challenge, with long-term implications for individuals and healthcare systems. Existing studies on the association between pediatric obesity and healthcare use in adulthood are limited and often rely on mathematical simulation models. This study aims to provide real-world data on the impact of adolescent obesity on specialized healthcare utilization and costs in early adulthood.

Effect of Pediatric Obesity Treatment on Long-Term Health.

Importance: Data regarding the long-term impact of treating childhood obesity on the risk of obesity-related events, including premature mortality, are limited.

Objective: To evaluate the long-term effect of different responses to pediatric obesity treatment on critical health outcomes in young adulthood.

Design, Setting, And Participants: The study included a dynamic prospective cohort of children and adolescents with obesity within The Swedish Childhood Obesity Treatment Register (BORIS) and general population comparators, linked with national registers.

Challenges and strategies in the soluble expression of CTA1-(S14P5)4-DD and CTA1-(S21P2)4-DD fusion proteins as candidates for COVID-19 intranasal vaccines.

Developing intranasal vaccines against pandemics and devastating airborne infectious diseases is imperative. The superiority of intranasal vaccines over injectable systemic vaccines is evident, but developing effective intranasal vaccines presents significant challenges. Fusing a protein antigen with the catalytic domain of cholera toxin (CTA1) and the two-domain D of staphylococcal protein A (DD) has significant potential for intranasal vaccines.

One-day low-residue diet is equally effective as the multiple-day low-residue diet in achieving adequate bowel cleansing: a meta-analysis of randomized controlled trials.

Background/aims: Colonoscopy is widely used as a diagnostic and preventive procedure for colorectal diseases. The most recent guidelines advocate the use of a low-residue diet (LRD) for bowel preparation before colonoscopy. LRD duration varies considerably, with recommended 1-day and multiple-day regimens in clinical practice.

A review of particulate matter (PM) in Indonesia: trends, health impact, challenges, and options.

This study reviews particulate matter (PM) research in Indonesia, focusing on current trends, health impacts, challenges, and future research directions. As the largest archipelago country, Indonesia faces severe pollution annually due to rapid urbanization, industrial activities, vehicle emissions, and forest fires. PM levels often exceed WHO and NAAQS standards, especially in urban areas and during forest fire seasons, posing significant health risks to vulnerable populations.

Reduction-immobilizing strategy of polymer-embedded sub-2 nm Cu nanoparticles with uniform size and distribution responsible for robust catalytic reactions.

Polymer-embedded metal nanoparticles are in great demand owing to their unique features, leading to their use in various important applications, including catalysis reactions. However, particle sintering and aggregation are serious drawbacks, resulting in a drastic loss of catalytic activity and recyclability. Herein, a reduction-immobilizing strategy of polymer-embedded sub-2 nm Cu nanoparticles offered highly controlled distribution and nanoparticle size within polymer structures with high fidelity.

Efficacy of ColonFlag as a Complete Blood Count-Based Machine Learning Algorithm for Early Detection of Colorectal Cancer: A Systematic Review.

Background: Colorectal cancer (CRC) screening is essential to reduce incidence and mortality rates. However, participation in screening remains suboptimal. ColonFlag, a machine learning algorithm using complete blood count (CBC), identifies individuals at high CRC risk using routinely performed tests.

Steatotic Liver Disease in Pediatric Obesity and Increased Risk for Youth-Onset Type 2 Diabetes.

Objective: To assess 1) the association between metabolic dysfunction-associated steatotic liver disease (MASLD) in pediatric obesity and youth-onset type 2 diabetes, 2) the joint effect of MASLD and intermediate hyperglycemia on type 2 diabetes risk, and 3) the effect of obesity treatment on type 2 diabetes risk.

Research Design And Methods: A cohort study using the Swedish Childhood Obesity Treatment Register (Barnobesitas Registret i Sverige [BORIS]) (1999-2020) linked with national registers was conducted. We included 10,346 children with overweight or obesity and 59,336 matched control individuals.

Embracing leadership of local actors and community in disaster risk reduction of Yogyakarta.

Unlabelled: The Disaster Preparedness Village (Kampung Siaga Bencana or KSB) in Special Region of Yogyakarta Province (DIY) is a community that aims to increase community preparedness and resilience to disasters through collaboration between the local government, non-government organisations and the community. This research examines the sustainability factors of KSB, namely the role of local leadership and government collaboration in disaster risk reduction (DRR) efforts. The method used in this research is a qualitative method and Strength, Weakness, Opportunity and Threat (SWOT) analysis, then using a diamond model to visualise the role of local leadership and the role of government.

Effect of crystallite size reduction and widening of optical phonon vibration due to AC variation on ZnO/Mg composites in implementation of methylene blue degradation.

The fashion industry's reliance on dyes contributes significantly to environmental pollution, which disturbs the ecological balance. To address this issue, we used ZnO/Mg combined with activated carbon (AC) at various concentrations (0.1 g, 0.

An Awareness of Pharmacovigilance Among Healthcare Professionals Due to an Underreporting of Adverse Drug Reactions Issue: A Systematic Review of the Current State, Obstacles, and Strategy.

Background: Healthcare professionals play an essential role in reporting adverse drug reactions as part of pharmacovigilance activities. However, adverse drug reactions reported by healthcare professionals remain low.

Objective: The aim of this systematic review was to investigate healthcare professionals' knowledge, awareness, attitude, and practice on pharmacovigilance and adverse drug reaction reporting, explore the causes of the underreporting issue, and provide improvement strategies.