A novel medium size lactam ring analoges as antibacterial agents: Synthesis, biological evaluation and molecular docking studies.

A novel series of medium size (S)-3-alkyl-3,4,6,7-tetrahydro-1H-benzo[e][1,4]diazonine-2,5-dione analogues were synthesized from (E)-3-(2-nitrophenyl)acrylicacid reacting with various amino acid esters using Di-isopropyl Carbodiimide as a coupling agent. The final cyclization is carried out by using reagent 1-Ethyl-3(3-dimethylaminopropyl) Carbodiimide Hydrochloride. The synthesized compounds have been supported by Mass, H-NMR and C-NMR.