The Effect of Diabetes Medication on Cognitive Function: Evidence from the PATH Through Life Study.

Objective. To examine the effect of diabetes treatment on change of measures of specific cognitive domains over 4 years. Research Design and Methods.

Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease.

Objective: To examine the efficacy of body brain life (BBL), a 12-week online dementia risk reduction intervention.

Methods: BBL was evaluated in a randomized controlled trial in 176 middle-aged adults with >2 risk factors and <2 protective factors for Alzheimer's disease (AD) assessed on a brief screening instrument. Participants were randomized to BBL, BBL plus face-to-face group sessions (BBL + FF) or active control (control).

A self-report risk index to predict occurrence of dementia in three independent cohorts of older adults: the ANU-ADRI.

Background And Aims: The Australian National University AD Risk Index (ANU-ADRI, http://anuadri.anu.edu.

A 12-week multidomain intervention versus active control to reduce risk of Alzheimer's disease: study protocol for a randomized controlled trial.

Background: Disappointing results from clinical trials of disease-modifying interventions for Alzheimer's dementia (AD), along with reliable identification of modifiable risk factors in mid life from epidemiological studies, have contributed to calls to invest in risk-reduction interventions. It is also well known that AD-related pathological processes begin more than a decade before the development of clinical signs. These observations suggest that lifestyle interventions might be most effective when targeting non-symptomatic adults at risk of AD.

Development of a new method for assessing global risk of Alzheimer's disease for use in population health approaches to prevention.

Alzheimer's disease (AD) affects approximately 35 million people worldwide. Increasing evidence suggests that many risk factors for AD are modifiable. AD pathology develops over decades.

Multimorbidity is associated with higher out-of-pocket spending: a study of older Australians with multiple chronic conditions.

Most older Australians have at least one chronic health condition. The management of chronic disease is associated with potentially severe economic consequences for patients and their households, partially due to the financial burden associated with out-of-pocket costs for medical and health-related care. A questionnaire was mailed to a cross-sectional sample of older Australians in mid-2009, with 4574 responding.

Patient initiated aggression - prevalence and impact for general practice staff.

Background: Patient initiated aggression toward general practice staff can cause distress among staff, however, it is unknown how frequently practice staff experience patient aggression in the workplace. The aim of this study is to determine the national prevalence of patient aggression toward general practice staff.

Method: A clustered cross sectional survey involving general practice staff working in Australia.

A national survey of general practitioners' experiences of patient-initiated aggression in Australia.

Objective: To determine the prevalence of patient-initiated aggression toward general practitioners in Australia.

Design, Setting And Participants: A cross-sectional national survey, conducted during February-May 2010, of 3090 GPs in 19 Divisions of General Practice, purposively sampled to represent urban, rural and remote areas.

Main Outcome Measure: Proportion of GPs experiencing patient-initiated aggression.

The impact of chronic illness on workforce participation and the need for assistance with household tasks and personal care by older Australians.

People, along with their families, feel the impact of chronic illness in many areas of their lives. It has been known that those with chronic illness leave the workforce earlier than their peers, have lower incomes and often need additional support to manage their health and lives. However, limited information is available about whether chronic illness is already present prior to retirement, or has developed subsequently.

Biphasic effects of the anterior cingulate cortex stimulation on glabrous skin blood flow in rats.

A growing body of evidence indicates that the anterior cingulate cortex (ACC) is associated with sensory, cognition and emotion processing. We have shown that electrical stimulation of rat ACC depressed the spinal cord dorsal horn neuron activity in response to noxious stimuli, possibly through a release of GABA. GABA may elicit dorsal root reflexes (DRRs) to induce peripheral vasodilatation.