CORRECTION CRITERIA FOR THE BONE TISSUE STRUCTURE DISORDERS IN CHILDREN LIVING IN RADIOLOGICALLY CONTAMINATED TERRITORIES AFTER THE CHORNOBYL NPP ACCIDENT.

Objective: To determine the structure of abnormalities of bone tissue and substantiate the management tactics inacute lymphoblastic leukemia (ALL) pediatric patients and in children with no oncohematological disorders, livingin radiologically contaminated territories (RCT).

Materials And Methods: Children (n = 220) living in RCT were the study participants i.e.

DRIVERS OF HYPERFERREMIA IN CHILDREN LIVING ON RADIOLOGICALLY CONTAMINATED TERRITORIES AFTER THE CHNPP ACCIDENT IN UKRAINE.

Objective: assessment of clinical-hematological and metabolic-biochemical parameters of the of bone tissue and hormonal regulation depending on the serum iron content and radiation dose values in children living on radiologically contaminated territories after the ChNPP accident in Ukraine.

Materials And Methods: Children (n = 271) living on radiologically contaminated territories (RCT) of Ukraine were involved in the study. Three study groups were formed according to the serum iron level (SIL), namely group I with SIL 10.

EFFECT OF IRON ON BONE TISSUE METABOLISM AND THYROID FUNCTION IN CHILDREN LIVING ON RADIOLOGICALLY CONTAMINATED TERRITORIES SINCE THE ChNPP ACCIDENT.

Objective: identification of clinical and metabolic characteristics of osteogenesis and factors affecting bone mineral density (BMD) in children living in radioactively contaminated territories (RCT) after the ChNPP accident for the use of therapeutic and preventive measures aiming to reduce the incidence of disorders.

Materials And Methods: Children aged 4 to 18 years old (n = 539) were involved in the study within 4 age groups, namely under 7 years old, 7-10 years old, 10-14 years old, older than 14 years old. Studied parameters in children with a reduced BMD (85-65 relative units and under 65 relative units) were estimated vs.

[Therapeutic areas of the Republic of Tyva].

Unlabelled: The need to expand the resort and recreational potential in the Siberian Federal District is due to the growing need for sanatorium treatment and rehabilitation of the population. Balneological studies conducted in different regions of Siberia make it possible to position these territories as promising for resort and recreational activities.

Objective: Comprehensive integral assessment of the resort and recreational potential of the treatment areas of the Republic of Tyva.

EFFECT OF SOMEUNFAVORABLE FACTORS OF ENVIRONMENT ON THE SURVIVAL OF CHILDREN WITH ACUTE LEUKEMIA IN A LONG6TERM PERIOD AFTER ACCIDENT ON THE CHORNOBYL NPP.

Objective: Determine of the influence of adverse environmental factors, including irradiation, on the survival ofchildren with acute leukemia in the long-term period after the Chornobyl accident (2008-2017).

Materials And Methods: Examined 74 children with acute leukemia (АL): 64 with acute lymphoblastic leukemia(ALL); 10 - acute myeloblastic leukemia (AML). The influence of negative environmental factors was assessed bythe degree of integrated pollution of the atmospheric air, surface waters and soils with pesticides, heavy metals (Pb,Cu, Ni, Cr, Mn, Zn, Fe) and cesium isotope 137Cs.

Cortisol level as risk factor for malignant hematologic pathology in children exposed to ionizing radiation after Chornobyl accident.

Objective: Determination of serum cortisol level in the initial period of acute leukemia in children, who exposed to ion izing radiation and other factors of Chornobyl accident, depending on their age and prognosis of disease.

Materials And Methods: The study involved 283 children residents of Kyiv, Zhytomyr and Chernihiv regions. There were 90 acute leukemia patients(AL) (ALL - 56, AML - 34), and 193 people of comparison group with anemia, leukemoid reactions and lymphadenopathy.

State of erythroid, granulocyte and platelet branches of hematopoiesis on stages of chemotherapy in children with acute lymphoblastic leukemia, who were exposed to ionizing radiation after the Chornobyl NPP accident.

Objective: Evaluation of proliferation and differentiation processes of progenitor cells in bone marrow by the com position of elements of erythroid, granulocyte and platelet branches of hematopoiesis on the treatment stages in children with acute lymphoblastic leukemia (ALL), who were exposed to radiation from the Chornobyl NPP accident.

Materials And Methods: The 46 children with ALL were studied, who lived in Kyiv, Zhytomyr and Chernihiv regions. Studies were conducted before the start of chemotherapy (ChT), on the 33 day of ChT (phase I), and after the com pletion of ChT (phase II).

[DEFINITION OF INTERRELATION BETWEEN AMINOACID COMPOSITION OF URINE AND BONE TISSUE DENSITY AT CHILDREN WITH ACUTE LEUKAEMIA FOR ONCOHEMATOLOGICAL PATHOLOGY RISK GROUP FORMATION].

Age and sexual indexies of densitometry at patients with acute leukemia (AL) and healthy children are presented. 31% of children with AL during the initial period of disease had manifestations of the osteopenic syndrome. At patients with AL more often than at healthy children anomalies of development of front part of skull are defined.

[Analysis of results of drug therapy for symptomatic multiple myeloma].

Drug therapy for symptomatic multiple myeloma is comparable for both sexes in its effectiveness and safety. A 3-year event-free survival is comparable in men and women; overall survival in men is lower than in women.

Rationale treatment and preventive measures for correction of bone structure in children with acute leukemia, exposed to ionizing radiation due to the Chornobyl accident.

Objective. To justify and evaluate the effectiveness of treatment and preventive measures taken to correct the bio-chemical and biophysical changes in the structure of bone in children exposed to ionizing radiation due to Chornobyl accident in the dynamics of leukemic process. Materials and methods.

[The results of proton radiosurgery for pituitary endosellar adenomas].

465 patients with pituitary endosellar adenomas have passed irradiation on the synchrocyclotron PNPI (1000 MeV). Due to the high energy of the proton beam the rotating-convergent shoot-through technique was used. The single dose of 80-100 Gy was given.

[The assessment of changes in the quality of prepacked therapeutic peloids from Siberia during their storage].

The results of evaluation of the qualitative characteristics of prepacked therapeutic peloids from Siberian lakes and changes of their physicochemical properties during storage are presented. The optimal shelf life of prepacked peloids and package size ensuring conservation of their natural therapeutic properties have been determined.

[The role of mud-forming microflora in the generation of biological activity of therapeutic peloids from Siberia].

The authors report the results of comprehensive evaluation of medicinal salt-saturated silt sulfide peloids from the bottom deposits of several lakes in the Novosibirsk and Altai regions. These peloids are extensively used for therapeutic and recreational purposes and appear to have good prospects for even a wider application in the future. The role of autochthonous microflora in the formation of peloid biological activities and antimicrobial properties has been elucidated.

[Clinical application of the plasma substitutes in patients with postoperative complications after surgeries for brain meningioma].

The issues on optimization of the restoration treatment of patients, suffering the brain meningioma, were discussed, basing on analysis of 498 observations. Tactics of the patients management in noncomplicated, complicated and severe course of postoperative period is adduced. The indices of survival and lethality, peculiarities of the infusion therapy were analyzed.

[Endothelial dysfunction in patients with angina pectoris of functional classes II and III].

Hemostatic parameters and the diameter of the brachial artery were studied in patients with functional classes II and III angina on exertion before and after an ischemic test. A multivariate statistical analysis was used to determine the significant parameters that distinguish vascular endothelial function in these patients. At the same time it was established that endothelial dysfunction in patients with varying angina pectoris is determined by different predictors of thrombocytic-vascular hemostasis.

Modeling of analytical peaks: peaks properties and basic peak functions.

The general approach to the detailed characterizing of peak properties based on the use of characteristic points on a peak contour located at the certain levels is proposed. Three basic functions of peaks have been chosen which are submitted in normalized form on height and width. The ability to characterize a peaks shape of a certain analytical series is shown by an example of series of analytical peaks of thallium obtained by stripping voltammetry at linear and step potential sweep.

[Results of proton therapy in the treatment of pituitary prolactin-secreting adenomas].

The paper presents follow-up results of narrow-beam proton therapy (1000 MeV) in 75 female patients suffering from prolactin-secreting pituitary adenomas. Prolactin concentrations reduced both in macro- and microprolactinomas patients. The response was achieved in 96% of the cases in adenoma stages I-IIIa.

[Mechanisms of action of high and superhigh doses of gamma-quanta and neutrons on the central nervous system].

Wistar rats were exposed to gamma-quanta (60Co, 100-400 Gy) and neutrons (100-200 Gy). The C. N.

[Radiation-induced changes in critical organs in rats irradiated in the state of parabiosis].

A study was made of the influence of parabiosis on the critical organ status in rats exposed to supralethal doses. The presence of a nonirradiated partner was shown to accelerate the recovery processes both in the intestine and the haemopoietic organs. The X-ray dose leading to a 50% decrease in the number of crypts was 11.

[Effect of high and superhigh doses of 60Co gamma-quanta and fission neutrons on rats].

A transient form of acute radiation sickness could be distinguished in Wistar rats after total-body exposure to 60Co-gamma-rays in high doses (150-200 Gy). With local exposure of head, in addition to direct damaging effect on the nervous system, the organismic factors play an important role in the development of the CNS syndrome. Effects of fractionation of superhigh doses of gamma-quanta and fission neutrons were not observed.