Swietenolide isolated from King in Hook seeds shows anti-colorectal cancer activity through inhibition of mouse double minute 2 (MDM2) homolog.

King in Hook (SM) is known to have several medicinal properties. Chloroform extracts of SM seeds (SMCE) as well as two isolated limonoids swietenine () and swietenolide () showed significant anti-CRC activity in human colon carcinoma (HCT116) cell line. (IC = 5.