Publications by authors named "Purkayastha Jayashree"
Introduction: Gut pathogen colonization, where pathogens disrupt the normal gut microbiota, has been implicated in the development of bloodstream infections (BSIs). This study investigates the association between gut pathogen colonization and BSI, hypothesizing that species causing BSI primarily originated from gut.
Methods: A prospective cohort study was conducted in the neonatal intensive care unit (NICU) of tertiary care hospital in Karnataka, India, from January 2021 to September 2023.
Introduction: Antimicrobial resistance (AMR) is a global problem, which is particularly challenging in developing countries like India. This study attempts to determine the competencies of health care professionals and to update evidence-based policies to address AMR.
Method: A survey-based educational interventional study was conducted using a validated structured survey and knowledge questionnaire under 3 domains through an antimicrobial stewardship program.
Objective: The study aimed to interpret and establish patterns of amplitude-integrated electroencephalogram (aEEG) in stable preterm neonates and compare the aEEG among different gestational age groups using three standard classifications.
Methods: This prospective cohort study included stable preterm neonates between 24 and 36 weeks of gestation. aEEG was recorded in the first and second week of life and interpreted using the L.
Background: The gut microbiota, comprising billions of microorganisms, plays a pivotal role in health and disease. This study aims to investigate the effect of sepsis on gut microbiome of neonates admitted to the Neonatal Intensive Care Unit.
Methods: A prospective cohort study was carried out in the NICU of tertiary care hospital in Karnataka, India, from January 2021 to September 2023.
The microbiota in the intestine is made up of trillions of living bacteria that coexist with the host. Administration of antibiotics during neonatal infection causes depletion of gut flora resulting in gut dysbiosis. Over the last few decades, probiotics have been created and promoted as microbiota management agents to enrich gut flora.
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- Advances in genomic technologies have improved the understanding of epilepsy's genetic factors, aiding in diagnosis, treatment, and genetic counseling for affected families.
- In a study of 142 Indian families, 44% received a clear epilepsy syndrome diagnosis, with a significant portion linked to severe conditions like developmental epileptic encephalopathy.
- A definitive molecular diagnosis was achieved in 52% of families, uncovering various genetic disorders and variants, many of which were novel and had notable implications for treatment and recurrence risk.
Objectives: To assess the growth pattern of preterm, very low birth weight (VLBW) appropriate for gestational age (AGA) infants on three different feeding regimens.
Methods: This prospective open label three-arm parallel randomized controlled trial was conducted at neonatal intensive care unit, Kasturba Hospital, Manipal. One hundred twenty VLBW (weight between 1000-1500 g and gestational age 28-32 wk) preterm AGA infants admitted from April 2021 through September 2022 were included.
Introduction: Minimally invasive tissue sampling of the brain in newborns using the Bard Monopty needle helps to diagnose various neurological conditions by obtaining relevant brain cores. We designed a modified procedure to provide maximum diagnostic utility in brain tissue biopsies.
Method: Twenty newborns underwent postmortem minimally invasive tissue sampling of the brain through the anterior fontanelle and posterior approach, using the engraved lines on the needle labeled from mark 0 to 13.
Background: Kangaroo mother care (KMC) is a proven intervention for intact survival in preterms. Despite evidence, its adoption has been low. We used a point of care quality improvement (QI) approach to implement and sustain KMC in stable low birthweight babies from a baseline of 1.
View Article and Find Full Text PDFBackground: Minimally invasive tissue sampling (MITS) of organs has been used as an alternative to complete diagnostic autopsy in countries where refusal for autopsy in newborns is common for sociocultural reasons. There is a paucity of literature regarding the diagnostic utility of MITS of the brain after death in neonates with neurological insults, especially in India.
Methods: This was a prospective, preliminary single-center tertiary care hospital study in India, focused specifically on MITS of the brain after neonatal death as a diagnostic tool to identify the various neurological insults.
Objective: To study the serum vitamin D levels in neonatal seizures and vitamin D status of the mothers whose babies had vitamin D deficiency.
Methods: For this cross-sectional study, vitamin D levels were studied in term and late preterm neonates admitted to NICU with seizures at our tertiary care center. Controls were term and late preterm healthy neonates admitted in the postnatal ward with the mothers in the same center.
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- This study evaluates the heart effects of caffeine vs. aminophylline in preterm neonates with a focus on how each substance impacts blood flow and heart function.
- Both medications showed similar overall results, but significant differences were noted in heart rates, with aminophylline increasing heart rates more than caffeine.
- While both treatments improved certain heart metrics like volume, caffeine had specific effects on smaller-for-gestational-age infants, leading to different cardiac responses compared to aminophylline.
Introduction: Facilitation of child development is usually emphasized in the form of early intervention classes and practical demonstrations. However, non-adherence to home program for such interventions has been reported due to various reasons.
Aim: To develop and validate an educational leaflet as a supplement guide for caregivers to promote better development of their child during 4-6 months of age.
Therapeutic hypothermia is well known for neuroprotection in asphyxiated neonates with hypoxic ischemic encephalopathy. The authors aimed to study the feasibility and safety of therapeutic hypothermia and short term outcome in neonates with hypoxic ischemic encephalopathy (HIE). Total 31 neonates with moderate to severe HIE were enrolled in the study.
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- Recent advances in neonatology have led to varied impacts on the incidence and severity of Retinopathy of Prematurity (ROP) in preterm infants.
- A study analyzed 282 preterm infants to identify the incidence of ROP, finding an overall occurrence of 21.6% and severe cases at 6.7%.
- Key risk factors included low birthweight (<1250 g) and gestational age (31-32 weeks) for any ROP, while intraventricular hemorrhage was specifically linked to severe ROP cases.
Early neonatal meningitis with non-fermenting Gram negative bacilli (NFGNB) is rare, and whenever it occurrs, inanimate environment is usually implicated as the source. The authors report a case of neonatal meningitis and sepsis with Chryseobacterium indologenes, a rare non fermenting Gram negative bacterium with unusual antimicrobial susceptibility. Despite resistance to all the beta lactams, carbapenems and aminoglycosides, therapy with ciprofloxacin led to a favorable outcome.
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