Fibronectin expression in the intervertebral disc of monkey.

Background: Fibronectin, a large dimeric plasma glycoprotein found only in vertebrates, is a core component of several extracellular matrices. Integrin receptors regulate different cell activities. Fibronectin expression patterns in intervertebral disc have not been extensively studied.

VEGF, BMP-7, Matrigel(TM), hyaluronic acid, in vitro cultured chondrocytes and trephination for healing of the avascular portion of the meniscus. An experimental study in sheep.

Objective: To evaluate the effects of VEGF, BMP-7, Matrigel(TM), hyaluronic acid, in vitro cultured chondrocytes and trephination to promote and enhance the healing process of avascular meniscal tears in an animal model.

Methods: A longitudinal tear was produced in the inner avascular part of the meniscus of 24 sheeps. Each tear was treated with trephination technique and suture.