Publications by authors named "Puregmaa Khongorzul"
Article Synopsis
- Dendritic cells (DCs) are key players in immune tolerance, and their dysfunction contributes to autoimmune diseases like type 1 diabetes (T1D).
- In studies with NOD mice, expressing an active form of the Stat5b signaling pathway in DCs restored their ability to promote tolerance, thus protecting against diabetes.
- This research revealed that DCs from transgenic mice exhibited a tolerogenic profile marked by increased expression of PD-L1 and PD-L2, along with changes in different DC subsets and signaling molecules, highlighting the essential role of the Stat5b-Ezh2 pathway in maintaining immune tolerance.
Dendritic cells (DCs) are key regulators of the adaptive immune response. Tolerogenic dendritic cells play a crucial role in inducing and maintaining immune tolerance in autoimmune diseases such as type 1 diabetes in humans as well as in the NOD mouse model. We previously reported that bone marrow-derived DCs (BM.
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- Type 1 diabetes (T1D) is caused by the destruction of pancreatic beta cells primarily by T cells, with dendritic cells (DCs) playing a key role in disease initiation and progression.
- Recent research highlights the function of DCs as antigen-presenting cells that influence T cell responses by integrating signals from tissue damage and presenting antigens to naïve T cells.
- Current therapeutic strategies aim to suppress the pro-inflammatory actions of DCs and enhance their ability to promote immune tolerance, focusing on both blocking T cell activation and promoting regulatory T cell populations to combat T1D.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a frustrating and often debilitating disease. Current studies have shown that Traditional Chinese Medicine (TCM) can improve patients' quality of life and alleviate CP/CPPS symptoms. In this study, the efficacy of Hedyotis diffusa Willd aqueous extraction in experimental autoimmune prostatitis (EAP) mice models was revealed.
View Article and Find Full Text PDFAntibody-drug conjugates (ADC) are one of the fastest growing anticancer drugs. This approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that directed toward a target antigen expressed on the cancer cell surface, reducing systemic exposure and therefore toxicity. ADCs are complex molecules that require careful attention to various components.
View Article and Find Full Text PDFChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a frustrating syndrome. The pathogenesis and state of the art treatment of CP/CPPS are not known. A wide variety of therapies including anti-inflammatories, antibiotics, alpha-blockers, neuropathic pain modulators, and 5α-reductase inhibitors are in practice.
View Article and Find Full Text PDFOxidative stress (OS) is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body that can cause tissue damage. Oxidative stress has a significant involvement in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and male infertility. CP/CPPS is a major risk factor for male infertility due to generation of excessive ROS that damage sperm DNA, lipids, and proteins, resulting in compromised vitality and decreased sperm motility.
View Article and Find Full Text PDFProstatitis is a common urinary tract syndrome that many doctors find problematic to treat effectively. It is the third most commonly found urinary tract disease in men after prostate cancer and Benign Prostate Hyperplasia (BPH). Prostatitis may account for 25% of all office visits made to the urological clinics complaining about the genital and urinary systems all over the world.
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