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Publications by authors named "Puppala Sahitya"

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Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach.
Perumal Yogeeswari Dharmarajan Sriram Puppala Sahitya Jegadeesan Vaigunda Ragavendran Velagaleti Ranganadh

Bioorg Med Chem Lett

July 2007

Article Synopsis
  • A series of ameltolide-GABA-amide hybrids were created and tested for their ability to prevent seizures and their potential neurotoxic effects.
  • The testing involved methods like maximal electroshock-induced seizure and pentylenetetrazole-induced seizure to assess their anticonvulsant properties, and all compounds showed good absorption in the brain.
  • Compound 7 was identified as the most effective, successfully reducing seizures in all tested models without causing any neurotoxic side effects.
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