Successful living-related renal transplantation in a patient with factor H antibody-associated atypical hemolytic uremic syndrome.

CFH-Ab-associated aHUS requires different diagnostic and therapeutic approaches and then the genetically defined aHUS forms. The risk of post-transplant recurrence with graft dysfunction in CFH-Ab aHUS is not well documented. It is suggested that recurrence can be expected if a significant CFH-Ab load persists at the time of transplantation.

Nationwide renal biopsy data in Lithuania 1994-2012.

Background: Our aim was to evaluate the incidence of biopsy-proven kidney diseases in Lithuania and to compare their changes in three different time intervals. All Lithuanian kidney biopsies were performed in the National Center of Pathology, enabling analysis at the national level.

Methods: The native kidney biopsy data were reviewed, and incidence of renal disorders and patient demographics were compared during three time intervals: 1994-1999, 2000-2006, and 2007-2012.

Long-term follow-up of children with typical hemolytic uremic syndrome.

Objective: The aim of the study was to determine the associations of the acute period course with late-emerging sequelae in children with typical hemolytic uremic syndrome (HUS).

Materials And Methods: The data of 62 children with typical HUS during the acute phase were retrospectively analyzed by age, sex, duration of anuria/oliguria, method and duration of renal replacement therapy, proteinuria, hypertension, and renal function. The data of 33 children at 10-year follow-up after the onset of the disease were evaluated for changes in hypertension, proteinuria, and renal function.

Prevalence and predictors of the sub-target Hb level in children on dialysis.

Background: Anaemia is a common and potentially treatable co-morbidity of end-stage renal disease. We aimed to determine the prevalence of the sub-target haemoglobin (Hb) level among European children on dialysis and to identify factors associated with a low Hb level.

Methods: From the European Society for Paediatric Nephrology (ESPN)/European Renal Association-European Dialysis Transplant Association (ERA-EDTA) registry, data were available on 2351 children between 1 month and 18 years of age, totalling 5546 measurements from 19 countries.

Typical renal-coloboma syndrome phenotype in a patient with a submicroscopic deletion of the PAX2 gene.

We present a patient with optic nerve hypoplasia, secondary strabismus, mild deafness, abnormal external ear helices, and renal hypoplasia. The clinical phenotype was consistent with renal-coloboma syndrome, but no point mutation in the PAX2 gene could be identified. High-resolution array comparative genomic hybridization (aCGH) analysis showed that this patient has a submicroscopic deletion on chromosome 10, affecting the entire coding region of the PAX2 gene.

Acute kidney injury in pediatric patients: experience of a single center during an 11-year period.

Unlabelled: The aim of our study was to determine the causes of acute kidney injury (AKI) in children, to compare outcomes between two periods--1998-2003 and 2004-2008--and to evaluate the influence of new methods of renal replacement therapy on mortality.

Material And Methods: A retrospective analysis of medical record data of all children treated for AKI at the Clinic of Children Diseases, Hospital of Kaunas University of Medicine, during the period of 1998-2008 was made. Both periods were compared regarding various variables.

Cisplatin increases urinary sodium excretion in rats: gender-related differences.

OBJECTIVE. There are well-documented reports of cisplatin-associated hyponatremia in the literature, but there are no data on gender-dependent differences. The aim of the present study was to define characteristics of 24-hour urinary sodium excretion in young adult Wistar rats of both genders and to evaluate the gender-related effect of cisplatin.

Recurrent urinary tract infection in girls: do urodynamic, behavioral and functional abnormalities play a role?

Background: To determine urodynamic, behavioral and functional abnormalities predisposing to recurrent urinary tract infection in 5- to 17-year-old girls.

Methods: A prospective case-control study was carried out. A total of 148 girls met inclusion criteria.

Characteristics of gender-related circadian arterial blood pressure in healthy adolescents.

Summary Objective: To define 24-h characteristics of arterial blood pressure in healthy adolescent girls and boys; to determine gender-related differences of blood pressure, its circadian pattern.

Material And Methods: The 24-h blood pressure was monitored hourly in healthy girls (n=22, without no account for the menstrual cycle phase) and boys (n=22). Additionally, blood pressure of adolescent girls (n=15) was examined during different phases of their menstrual cycle (follicular, ovulation, and luteal).

[The clinical course and long-term outcome of hemolytic-uremic syndrome in children].

The aim of this study was to evaluate the long-term outcome of hemolytic-uremic syndrome in children and the dependence of outcome on severity of the acute phase of the illness. We analyzed data of 20 children who were hospitalized and treated at the Clinic of Children's Diseases, Kaunas University of Medicine Hospital, during 1995-2006. Data were obtained from case histories and outpatient case records with the help of prepared questionnaire.

[Postinfectious glomerulonephritis in children in Lithuania during 1995-2004: prevalence and clinical features].

During the period of 1995-2004, acute postinfectious glomerulonephritis was diagnosed in 322 children aged 1-16 years. An outbreak of acute postinfectious glomerulonephritis was registered in 1995, with a prevalence of 8.3 cases per 100,000 children; during 2003-2004 prevalence decreased and it was 2.

[Etiology, prevalence of chronic renal failure and growth retardation in Lithuanian children].

The aim of the study was to evaluate the causes, prevalence, and grades of chronic renal failure in Lithuanian children and to assess its influence on children's growth. The study was performed in Vilnius University Children's Hospital and Clinic of Children's Diseases, Kaunas University of Medicine. By March 31, 2006, 65 children with chronic renal failure had been registered.

[Etiology and outcomes of acute renal failure in childhood].

The aim of the research was to determine causes of acute renal failure in children, their outcome and to define risk factors associated with mortality. 75 children with acute renal failure, who were treated at the Clinic of Children's Diseases of Kaunas University of Medicine between 1998-2003 years, were included in the study. The age range of patients was 1 month to 16 years.

[Dysfunction of lower urinary tract in 5-18 years old children with recurrent urinary tract infections].

The purpose of this article was to evaluate function of lower urinary tract for 5-18 years old children with recurrent urinary tract infections and to compare urodynamic changes in two groups: with recurrent lower urinary tract infections and with recurrent upper urinary tract infections. 35 urodynamic studies in 5-18 years old children (3 boys and 32 girls) with recurrent urinary tract infection were performed at the Clinic of Children's Diseases of Kaunas University of Medicine in 2004. 21 of these children had recurrent lower urinary tract infections and 14 recurrent upper urinary tract infections.

[Hemolytic-uremic syndrome in Lithuania over the period 1990-2004].

More than 80 cases of the hemolytic-uremic syndrome were registered in Lithuania over the period 1990-2004. The incidence of this syndrome fluctuated annually; higher incidence rates were observed in 1990-1993, 1998-1999 and 2003-2004, however, there was no overall increase in morbidity over the 15-year period. Most cases occurred in the first two years of life; besides, girls suffered slightly more often than boys.

Denys-Drash syndrome.

Constitutional missense mutations in the WT1 gene are usually associated with Denys-Drash syndrome. This rare syndrome is characterized by a rapid progressive nephropathy, male pseudohermaphroditism, and an increased risk for Wilms tumor. We report on a patient with incomplete Denys-Drash syndrome, which was evident by the clinical data and proved by molecular genetics methods.

[Changes of etiology and management of childhood urinary tract infection during the period of 1994-2002 (data of Kaunas University of Medicine Hospital)].

The purpose of this article was to establish changes of age, etiology, diagnostics and treatment for children, who were treated for urinary tract infection in Clinic of Children Diseases, Kaunas University of Medicine Hospital in 1994-1998 and 1999-2002. Seven hundred fifty children urinary tract infections were treated during the period of 1994-1998, and 673--during the period of 1999-2002. Female patients had urinary tract infection nearly five times more than male patients in other age groups.

[The value and adaptability of glomerular filtration rate and reserve test (review of the literature)].

In normal conditions only 75% of kidney function capability are in use. Resting part of kidney function is called renal functional reserve. It is a very important indicator for prediction of renal insufficiency in chronic renal diseases, morphological changes or reduced mass of kidney parenchyma.