Publications by authors named "Pulcini C"

Background: This systematic review evaluates the effect of audit and feedback (A&F) interventions targeting antibiotic prescribing in primary care and examines factors that may explain the variation in effectiveness.

Methods: Randomized controlled trials (RCTs) involving A&F interventions targeting antibiotic prescribing in primary care were included in the systematic review. Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, and ClinicalTrials.

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Background: Antibiotic resistance is a major public health threat, especially in nursing homes (NHs). Nursing home nurses (NHNs) can play a crucial role in antimicrobial stewardship (AMS), but research on their opinions regarding potential expanded AMS roles is limited.

Objectives: To identify different profiles of NHNs according to their opinions on the potential evolution of their AMS roles and to study facilitators/barriers to implementing new AMS roles and the demographic and professional characteristics associated with these profiles.

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Background: Antimicrobial stewardship (AMS) programs aim to optimize antibiotic use through a panel of interventions. The implementation of computerized clinical decision support systems (CDSSs) offers new opportunities for semiautomated antimicrobial review by AMS teams. This study aimed to evaluate the perceived facilitators, barriers and benefits of end-users related to a commercial CDSS recently implemented in a hospital and to assess its usability.

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Introduction: Trauma-informed care has been posited as a framework for creating ideal and safe environments for patients to participate in treatment. However, there are limited studies that demonstrate the impact of a focused trauma-informed care training on ED staff. We implemented a 4-hour trauma-informed care training in a general emergency department.

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Case Presentation: An 8-month-old infant presented to a general emergency department with chief complaints of rhinorrhea, decreased activity, and fever. A point-of-care lung ultrasound (LUS) was performed at bedside with potential early findings of pneumonia. Based on these findings on LUS, a chest radiograph (CXR) was ordered and performed with no acute findings.

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Objective: Addressing the acute mental healthcare needs of children is a national crisis. Despite the ongoing crisis, there are limited prior studies that capture caregiver perspectives on acute pediatric mental healthcare, notably in a general emergency department (ED) in a rural state. Based on these knowledge gaps, our objective was to assess caregiver opinions and perspectives of acute management for children boarding with mental health conditions.

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Introduction: Trauma-informed care has been posited as a framework to optimize patient care and engagement, but there is a paucity of data on patient-level outcomes after trauma-informed care training in health care settings. We sought to measure patient-level outcomes after a painful procedure after implementation of trauma-informed care training for ED staff.

Methods: As part of a quality improvement initiative, we trained 110 ED providers in trauma-informed care.

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In this secondary analysis of a multicenter investigation, we describe several gaps in the collection and management of pediatric race, ethnicity, and language data. These findings highlight the ongoing need for reliable data management processes as a crucial step toward advancing pediatric health equity.

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Background: Antibiotic overuse and misuse in primary care are common, highlighting the importance of antimicrobial stewardship (AMS) efforts in this setting. Audit and feedback (A&F) interventions can improve professional practice and performance in some settings.

Objectives And Methods: To leverage the expertise from international members of the Joint Programming Initiative on Antimicrobial Resistance - Primary care Antibiotic Audit and feedback Network (JPIAMR-PAAN).

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Background: GPs are responsible for more than 70% of outpatient antibiotic prescriptions in France. Metrics are important antibiotic stewardship tools that can be used to set targets for improvement and to give feedback to professionals and stakeholders.

Objectives: The primary objective of the present study was to select a set of proxy indicators (PIs) based on 10 previously developed PIs, to estimate the appropriateness of antibiotic prescriptions by GPs.

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Improving the overall care of children with medical complexity (CMC) is often beset by challenges in proactively identifying the population most in need of clinical management and quality improvement. The objective of the current study was to create a system to better capture longitudinal risk for sustained and elevated utilization across time using real-time electronic health record (EHR) data. A new Pediatric Population Management Classification (PPMC), drawn from visit diagnoses and continuity problem lists within the EHR of a tristate health system, was compared with an existing complex chronic conditions (CCC) system for agreement (with weighted κ) on identifying CCMC, as well as persistence of elevated charges and utilization from 2016 to 2019.

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Article Synopsis
  • Antimicrobial stewardship programs are essential in long-term care facilities (LTCFs) to address the growing problem of antimicrobial resistance, and understanding factors influencing antibiotic use can help shape these programs.
  • A systematic review analyzed 57 studies that focused on various factors affecting antibiotic prescriptions, highlighting that many studies concentrated on resident-level and facility-level influences rather than prescriber-level factors.
  • Key findings included that comorbidities, history of infection, and specific medical conditions significantly increased antibiotic prescriptions among residents, while facility characteristics like staff turnover and availability of on-site coordinating physicians also impacted prescription volumes.
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Article Synopsis
  • The WHO Model List of Essential Medicines (EML) focuses on prioritizing medicines that are crucial for global public health, particularly in the context of antibiotic use and resistance.
  • In response to the rise of antimicrobial resistance, the EML introduced a new classification system called AWaRe, which categorizes antibiotics into Access, Watch, and Reserve groups to guide appropriate usage.
  • The 2023 AWaRe classification includes 41 essential antibiotics and aims to enhance global antibiotic prescribing practices, promoting the use of Access antibiotics to optimize treatment and reduce misuse to prolong the effectiveness of these medications.
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  • A study was conducted in Lorraine, France, to assess the impact of a multifaceted antibiotic stewardship intervention on antibiotic prescriptions by general practitioners, focusing on the reduction of systemic and broad-spectrum antibiotics.
  • The intervention included a public commitment charter, patient leaflets, and non-prescription pads, with data analyzed over two periods (before and after the intervention).
  • Results showed a significant reduction in antibiotic prescriptions overall, but no strong evidence that the intervention contributed to this change; however, there was a slight trend toward decreased seasonal variation in antibiotic prescriptions.
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Article Synopsis
  • The study aimed to evaluate French nursing home nurses' views on their evolving roles in antibiotic stewardship, focusing on facilitators, barriers, and relevant nurse characteristics.
  • A cross-sectional survey was conducted by distributing a 43-item questionnaire to nursing homes, resulting in 923 complete responses from nurses.
  • Findings revealed that a majority of nurses supported expanded responsibilities, including collecting samples and changing antibiotic treatments, though those in public homes with hospital ties and less experience were less inclined to support prescribing antibiotics.
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Importance: Febrile infants at low risk of invasive bacterial infections are unlikely to benefit from lumbar puncture, antibiotics, or hospitalization, yet these are commonly performed. It is not known if there are differences in management by race, ethnicity, or language.

Objective: To investigate associations between race, ethnicity, and language and additional interventions (lumbar puncture, empirical antibiotics, and hospitalization) in well-appearing febrile infants at low risk of invasive bacterial infection.

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Background: Primary care is a critical partner for antimicrobial stewardship efforts given its high human antibiotic usage. Peer comparison audit and feedback (A&F) is often used to reduce inappropriate antibiotic prescribing. The design and implementation of A&F may impact its effectiveness.

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