, an Emerging Zoonotic Pathogen, Possesses the Capacity to Induce Cerebral Inflammatory Responses.

To date, three strains, BS26, BS27, and NN1, have been isolated from the blood cultures of patients with peritonitis, pneumonia, and arthritis, indicating that is an emerging threat to susceptible people. There is thus an urgent need to further evaluate the pathogenesis of clinical strains in order to design efficient anti-inflammatory strategies. Our previous study demonstrated the capacity of clinical strains to enter the central nervous system (CNS) of infected mice.

Characterization of integrative and conjugative elements carrying antibiotic resistance genes of isolated in China.

, an emerging zoonotic pathogen, is important reservoirs of antibiotic resistance genes that play critical roles in the horizontal transfer of corresponding resistances. In the present study, 656 antibiotic resistance (AR) genes were detected in 154 of 155 genomes of strains isolated from the nasopharynx of slaughtered pigs and the lungs of diseased pigs in China. The AR genes were clustered into 11 categories, consisting of tetracycline, macrolides, lincosamide, streptogramin, aminoglycoside, trimethoprim, amphenicols, nucleoside, quinupristin/dalfopristin, glycopeptide, and oxazolidinones resistance genes.

Comparative transcriptomic analysis reveal genes involved in the pathogenicity increase of epidemic strains.

epidemic strains were responsible for two outbreaks in China and possessed increased pathogenicity which was featured prominently by inducing an excessive inflammatory response at the early phase of infection. To discover the critical genes responsible for the pathogenicity increase of epidemic strains, the genome-wide transcriptional profiles of epidemic strain SC84 were investigated at the early phase of interaction with BV2 cells. The overall low expression levels of 89K pathogenicity island (PAI) and 129 known virulence genes in the SC84 interaction groups indicated that its pathogenicity increase should be attributed to novel mechanisms.

The characteristics of population structure and antimicrobial resistance of Streptococcus suis serotype 8, a non-negligible pathotype.

Streptococcus suis, the leading causative agent of swine streptococcosis, is considered as a severe zoonotic and foodborne pathogen for humans. Characteristics of population structure and pathogenicity of S. suis vary significantly by serotypes.

Genomic and pathogenic investigations of serotype 7 population derived from a human patient and pigs.

is one of the important emerging zoonotic pathogens. Serotype 2 is most prevalent in patients worldwide. In the present study, we first isolated one serotype 7 strain GX69 from the blood culture of a patient with septicemia complicated with pneumonia in China.

Investigation of the Genomic and Pathogenic Features of the Potentially Zoonotic .

Recently, reference strains of serotype 20, 22, and 26 were reclassified as . The public health significance of is underestimated due to the lack of clinical isolates. In the present study, we first reported two sporadic infections in humans, after using full-length 16S rRNA and housekeeping genes' phylogeny and ANI values of genome sequence comparisons to determine the species of their isolates BS26 and BS27.

Increase of Elderly Population in the Rainstorm Hazard Areas of China.

In light of global warming, increased extreme precipitation events have enlarged the population exposed to floods to some extent. Extreme precipitation risk assessments are of great significance in China and allow for the response to climate change and mitigation of risks to the population. China is one of the countries most influenced by climate change and has unique national population conditions.