Publications by authors named "Pujo J"
Introduction: French Guiana is a French territory in South America covered by 90% of tropical forest. Despite regular first aid standards training, some of the workers in isolated areas remain untrained in common problems they may encounter. We present here the knowledge assessment of these workers concerning first aid and a new training program.
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- Lancehead snakes (Bothrops) cause 90% of snakebites in Latin America, prompting a study on the effects of B. atrox venom in male and female mice.
- The research found that male mice exhibited a lower lethal dose (LD) and more severe physical symptoms from the venom compared to females, particularly via the intraperitoneal injection route.
- Hematological changes, including a significant drop in total leukocyte levels, were more pronounced in males, indicating a greater susceptibility to B. atrox venom and highlighting the need to consider sex differences in venom studies.
Introduction: Sexual violence is a major public health issue, including in French Guiana. The feeling of insecurity is significant in this part of France. Sexual violence is an important reason for consultation in forensic and emergency medicine.
View Article and Find Full Text PDFSnakebite envenoming is a high-priority neglected tropical disease and antivenom is the cornerstone of treatment. Antivenom is listed among essential medicines and its access must be considered as a human right. Despite resolutions from various international organizations including the WHO, antivenom remains unavailable, unaffordable, and sometimes not targeted against the specific snake involved.
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- Functional gastrointestinal disorders (FGIDs) affect over 40% of people globally, causing abdominal pain and altered bowel function, leading to significant economic costs and reduced quality of life.
- FGIDs have been reclassified as disorders of gut-brain interaction (DGBI), emphasizing the importance of the communication between the gut and the brain in these conditions and their association with mental health issues.
- The review explores current research on gut microbiome interactions and their role in DGBIs, suggesting that understanding these connections may lead to better treatments for these chronic disorders.
The purpose of this paper was to investigate the anti-inflammatory and anti-angiogenic activities of sulfated polysaccharide from (PCT) using carrageenan (CARR)-induced paw edema in a rat model and anti-vasculogenic activity on a chorioallantoic membrane assay (CAM) model. Based on in vitro tests of anti-radical, total antioxidant, and reducing power activities, PCT presents a real interest via its antioxidant activity and ability to scavenge radical species. The in vivo pharmacological tests suggest that PCT possesses anti-inflammatory action by reducing paw edema and leukocyte migration, maintaining the redox equilibrium, and stabilizing the cellular level of several pro-/antioxidant system markers.
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- The study explored how excess copper and zinc affect male reproductive health in mice, highlighting a significant decline in sperm quality and increased oxidative stress.
- Co-treatment with a polysaccharide extracted from green algae helped reduce these toxic effects and improved reproductive parameters.
- The findings suggest that this polysaccharide could be a promising protective agent against metal-induced reproductive toxicity.
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- * Out of 3,443 E. coli isolates, a significant percentage (64.4%) were β-lactamase producers, with common resistance mechanisms being penicillinase production; 6.1% had extended-spectrum β-lactamase (ESBL).
- * While susceptibility to certain antibiotics like amoxicillin/clavulanic acid declined, ciprofloxacin showed increased susceptibility; overall, resistance trends necessitate ongoing monitoring and efforts to reduce antibiotic use in the community.
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- Indonesia and French Guiana face similar challenges in emergency medical care access, particularly in the prehospital phase.
- Unlike in France, where emergency medicine is a fully developed specialty, Indonesia is still developing this field.
- A partnership was initiated between Jakarta University and French Guiana University, leading to the launch of a joint program in emergency medicine that started in August 2022, graduating its first class of 50 Indonesian doctors in August 2023.
Background: Acute poisonings (AP) are a significant public health problem, accounting for a high number of emergency department visits and thousands of deaths worldwide. This study aimed to assess the epidemiology of AP in an adult population admitted to Cayenne Hospital (French Guiana) and to investigate the clinical and sociodemographic characteristics.
Methods: We conducted a monocentric retrospective study from January 2010 to December 2022, including patients over eighteen years of age who had been admitted to the emergency department of Cayenne Hospital for acute poisoning.
Background: French Guiana (FG) is a French territory located in South America with the highest rate of armed assaults. FG presents a poorly developed road system and a young and precarious population that makes the geographical and socio-demographic characteristics specific. No data concerning the firearm injury management are available in this country.
View Article and Find Full Text PDFIn this study, we investigated for the first time the anti-inflammatory and immunomodulatory properties of crude polysaccharide (PSHT) extracted from green marine algae . PSHT exhibited anti-oxidant activity in vitro through scavenging 1, 1-diphenyl-2-picryl hydroxyl free radical, reducing Fe/ferricyanide complex, and inhibiting nitric oxide. PSHT maintained the erythrocyte membrane integrity and prevented hemolysis.
View Article and Find Full Text PDF(1) Background: Until December 2021, French Guiana (FG), located in South America, faced four consecutive COVID-19 epidemic waves. This study sought to analyze the mortality trend of severe COVID-19 patients admitted to the referral ICU of FG. (2) Methods: We conducted a prospective, observational, and non-interventional study in ICU at Cayenne Hospital.
View Article and Find Full Text PDFIntroduction: Stress exposure is a significant concern in the healthcare sector. This animal model study aims to reproduce caregivers' working conditions and determine their impact on the brain.
Method: Twenty-four healthy male rats of the Wistar strain were divided into four groups.
Sulfated polysaccharides from seaweed are highly active natural substances with valuable applications. In the present paper, attempts have been made to discuss the physicochemical and structural features of polysaccharides isolated from red marine alga (ACPs) and their protective effect in hepatic impairments induced by tebuconazole (TEB) in male adult rats. Structural features were determined using high-performance liquid chromatography, Fourier-transformed infrared, and solid-state H and C-Nuclear magnetic resonance analysis.
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- French Guiana is a unique region notable for its rich biodiversity and diverse communities, yet it faces paradoxes such as high poverty rates with 50% of the population living below the poverty line.
- The territory experiences a mix of health challenges, including common infectious diseases like HIV and malaria, which require tailored medical approaches due to their unique local characteristics.
- European resources in French Guiana facilitate advanced diagnostic and treatment options, enhancing research opportunities despite the smaller population compared to surrounding countries, and enabling better management of both common and rare diseases.
This study aimed to evaluate the potentiality of a mineral and antioxidant-rich methanolic extract of the red marine alga (FRE) against methyl-thiophanate (MT)-induced toxicity in adult rats. The animals were allocated into four groups: controls, MT (300 mg/kg), MT + FRE, and FRE-treated group for 7 days. Our results demonstrated severe mineral perturbations due to MT treatment, especially in calcium and phosphorus levels in plasma, urine, and bone.
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- Snakebite envenoming is an urgent medical issue in French Guiana, particularly affecting those in remote areas who often experience delays in accessing healthcare services.
- A study conducted at Cayenne General Hospital revealed a median time of 9 hours and 15 minutes from snakebite to antivenom treatment, with longer delays for patients from rural locations.
- Early administration of antivenom significantly improves recovery time for coagulation parameters, highlighting the need for improved access to antivenom in remote healthcare settings.
Bacterial resistance in community-acquired urinary tract infections (UTIs) is increasing worldwide. Our study aimed to assess the microbiological epidemiology and antimicrobial susceptibility patterns of community-acquired urine bacterial isolates in French Amazonia. Our study is retrospective.
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- Gut injury is linked to increased cell death in intestinal cells, often leading to chronic inflammatory diseases.
- This study explores the protective effects of polysaccharides from Tunisian red alga (PSGS) against toxic damage caused by hydrogen peroxide (HO) in IEC-6 cells.
- Results show that PSGS can restore cell viability and normal cell structure, and it appears to protect cells from oxidative stress and apoptosis caused by HO through its unique structural properties.
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- Abdominal pain is common in people with stomach issues, but scientists don't fully understand why it happens.
- Studies suggest that the tiny bacteria in our guts (gut microbiota) affect how we feel pain and that boys and girls might feel pain differently.
- Research with mice showed that those without gut bacteria were more sensitive to pain than those with bacteria, especially because of a chemical called CGRP in females.
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- Nine cases of hantavirus pulmonary syndrome were confirmed in French Guiana from 2008, all requiring admission to Cayenne Hospital.
- The disease progressed through two phases: the prodromal phase, with symptoms like fever and myalgia, and the illness phase, which led to respiratory failure in every patient.
- 55.6% of patients died, with survivors spending an average of 19 days in intensive care, highlighting the need for improved screening and surveillance for hantavirus infections.