Life cycle assessment and yield to optimize extraction time and solvent: Comparing deep eutectic solvents vs conventional ones.

Deep eutectic solvents (DES) are gaining interest as eco-friendly alternatives for extracting bioactive compounds, but their environmental benefits remain unclear and need further evaluation. In this work, a case study of total polyphenols (TPC) extraction from spent coffee grounds (SCG) was environmentally evaluated using life cycle assessment (LCA). First, the most convenient extraction time (1, 10, 20, or 40 min) for water and acetone 20 % from an environmental perspective was identified.

Weight loss benefits on HDL cholesterol persist even after weight regaining.

Background: Obesity-related comorbidities may relapse in patients with weight regain after bariatric surgery. However, HDL cholesterol (HDLc) levels increase after surgery and seem to remain stable despite a gradual increase in BMI. The aim of this study is to analyze the effects of weight regain after bariatric surgery on HDL cholesterol.

Circularity of new composites from recycled high density polyethylene and leather waste for automotive bumpers. Testing performance and environmental impact.

New composite materials (suitable for automotive bumpers), composed of recycled high-density polyethylene (rHDPE) and leather buffing dust waste (BF) ranging from 20 to 50 wt%, were produced and investigated for mechanical properties. Optimal mechanical performance was achieved with composites containing 30 % wt BF. The environmental performance of automotive bumper production from both virgin and recycled HDPE reinforced with 30 % wt BF (HDPE-BF, rHDPE-BF) composites was compared to that of conventional polypropylene (PP) by performing a cradle to gate life cycle assessment.

Extraction of Bioactive Compounds from Spent Coffee Grounds Using Ethanol and Acetone Aqueous Solutions.

Given global coffee consumption, substantial quantities of spent coffee grounds (SCGs) are generated annually as a by-product of brewing coffee. SCG, although rich in bioactive compounds, is nowadays disposed of. The objective of this study is to compare, for the first time and from the same SCG, the efficiency of ethanol-water mixtures and acetone-water mixtures for the recovery of total polyphenols, chlorogenic acid, and caffeine.

A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass.

Objective: To determine changes in incretins, systemic inflammation, intestinal permeability and microbiome modifications 12 months after metabolic RYGB (mRYGB) in patients with type 2 diabetes (T2D) and their relationship with metabolic improvement.

Materials And Methods: Prospective single-center non-randomized controlled study, including patients with class II-III obesity and T2D undergoing mRYGB. At baseline and one year after surgery we performed body composition measurements, biochemical analysis, a meal tolerance test (MTT) and lipid test (LT) with determination of the area under the curve (AUC) for insulin, C-peptide, GLP-1, GLP-2, and fasting determinations of succinate, zonulin, IL-6 and study of gut microbiota.

Environmental and Yield Comparison of Quick Extraction Methods for Caffeine and Chlorogenic Acid from Spent Coffee Grounds.

This study aims to provide an overview of different extraction methods to obtain chlorogenic acid (CA) and caffeine (Caf) from spent coffee grounds (SCG). This overview shows that the quantity extracted is highly dependent on the type of SCG, so experiments using the same SCG are needed to compare different methods. Three easy and simple extraction methods will be tested at a laboratory scale and environmentally compared.

Carbon Footprint: The Case of Four Chicken Meat Products Sold on the Spanish Market.

Despite its relatively low environmental impact within the livestock sector, the poultry sector still faces its own environmental challenges that need to be addressed. The present paper uses life cycle assessment to quantify greenhouse gas emissions, from cradle to slaughterhouse gate, of four chicken meat products: whole carcass, wings, breast fillets, and leg quarters. The main contribution of the present study is that it provides a detailed analysis of different chicken meat cuts, testing mass and economic allocation choices and showing that economic allocation better reflects the causality of the cutting process.

Classification of Textile Samples Using Data Fusion Combining Near- and Mid-Infrared Spectral Information.

There is an urgent need to reuse and recycle textile fibers, since today, low recycling rates are achieved. Accurate classification methods for post-consumer textile waste are needed in the short term for a higher circularity in the textile and fashion industries. This paper compares different spectroscopic data from textile samples in order to correctly classify the textile samples.

Post-Consumer Textile Waste Classification through Near-Infrared Spectroscopy, Using an Advanced Deep Learning Approach.

The textile industry is generating great environmental concerns due to the exponential growth of textile products' consumption (fast fashion) and production. The textile value chain today operates as a linear system (textile products are produced, used, and discarded), thus putting pressure on resources and creating negative environmental impacts. A new textile economy based on the principles of circular economy is needed for a more sustainable textile industry.

Water-Energy-Food Nexus and Life Cycle Thinking: A New Approach to Environmental and Nutritional Assessment of Potato Chips.

The water-energy-food (WEF) nexus has become a key concept to promote the cross-sectoral coordination toward sustainable development. In particular, understanding the interdependences of these pillars, as well as addressing a life cycle perspective, is essential when evaluating food production systems. This study explores the environmental impacts and nutritional quality of potato chips, addressing life cycle thinking and a WEF nexus approach.

Valorization Strategy for Leather Waste as Filler for High-Density Polyethylene Composites: Analysis of the Thermal Stability, Insulation Properties and Chromium Leaching.

Leather waste (BF) and high-density polyethylene (HDPE) were compounded in a lab scale internal mixer and processed by means of injection molding. In this study, leather waste and HDPE composites were characterized by instrumental techniques such as differential scanning calorimetry (DSC), thermo-gravimetric Analysis (TGA), and Fourier transform infrared spectroscopy (FTIR). Physical integrity of composites against chemical exposure and chromium-leaching properties of the composites were also investigated.

UniBind: maps of high-confidence direct TF-DNA interactions across nine species.

Background: Transcription factors (TFs) bind specifically to TF binding sites (TFBSs) at cis-regulatory regions to control transcription. It is critical to locate these TF-DNA interactions to understand transcriptional regulation. Efforts to predict bona fide TFBSs benefit from the availability of experimental data mapping DNA binding regions of TFs (chromatin immunoprecipitation followed by sequencing - ChIP-seq).

Towards a Water-Energy-Food (WEF) nexus index: A review of nutrient profile models as a fundamental pillar of food and nutrition security.

The Water-Energy-Food (WEF) nexus approach should be promoted as a tool for sustainable management of resources through the interconnection of these three fundamental pillars. Particularly, food security must ensure healthy and balanced diets for everyone, but selecting individual indicators to assess all slants covered by this element is not an easy task. Hence, the objective of this paper is two-fold, to review nutrient profiling (NP) models that allow to categorize foods and evaluate diets based on their nutritional quality, and to choose the most appropriate model to be used within a WEF nexus index.

Multi-Objective Optimization of Nutritional, Environmental and Economic Aspects of Diets Applied to the Spanish Context.

Current food consumption patterns must be revised in order to improve their sustainability. The nutritional, environmental, and economic consequences of these dietary patterns must be taken into consideration when diet guidelines are proposed. This study applied a systematic optimization methodology to define sustainable dietary patterns complying with nutritional, environmental, and economic issues.

Network Building with the Cytoscape BioGateway App Explained in Five Use Cases.

The BioGateway App is a plugin for the Cytoscape network editor, allowing users to interactively build biological networks by querying the Biogateway Resource Description Framework (RDF) triple store. BioGateway contains information from several curated resources including UniProtKB, IntAct, Gene Ontology Annotations, various datasets containing transcription-factor regulatory relations to specific target genes, and more. The BioGateway App facilitates the step-by-step creation of complex SPARQL queries through an intuitive Graphical User Interface, allowing users to build and explore biological interaction networks to assess, among other things, gene regulatory relationships, gene ontology annotations, and protein-protein interactions.

Leather Waste to Enhance Mechanical Performance of High-Density Polyethylene.

Leather buffing dust (BF) is a waste from tannery which is usually disposed on landfills. The interest in using wastes as fillers or reinforcements for composites has raised recently due to environmental concerns. This study investigates the potential use of BF waste as filler for a high density polyethylene matrix (HDPE).

Environmental and nutritional impacts of dietary changes in Spain during the COVID-19 lockdown.

The COVID lockdown has affected food purchases and eating habits. In this regard, this short communication assesses the nutritional and environmental impacts of these changes during the COVID lockdown in Spain, by applying Life Cycle Assessment and an energy- and nutrient-corrected functional unit. Three environmental impacts were studied (Global Warming Potential, Blue Water Footprint and Land Use) and a total of seven weekly diet scenarios were designed: two pre-COVID diets for March and April in 2019 (MAR19, APR19), one COVID diet (COVID) and two alternative diets, one based on the National Dietary Guidelines (NDG) and another one on the Planetary Health Diet (PHD).

Polylactic Acid/Polycaprolactone Blends: On the Path to Circular Economy, Substituting Single-Use Commodity Plastic Products.

Circular economy comes to break the linear resource to waste economy, by introducing different strategies, two of them being: using material from renewable sources and producing biodegradable products. The present work aims at developing polylactic acid (PLA), typically made from fermented plant starch, and polycaprolactone (PCL) blends, a biodegradable polyester, to study their potential to be used as substitutes of oil-based commodity plastics. For this, PLA/PCL blends were compounded in a batch and lab scale internal mixer and processed by means of injection molding.

Chromosomal aberration dynamics through the cell cycle.

DNA double-strand breaks are the crucial lesions underlying the formation of chromosomal aberrations, their formation and kinetics have been extensively studied, although dynamics of the repair process has not been fully understood. By using a combination of different cytogenetic techniques to analyze cells in G0, G2 and M phase, in the present study we perform a follow up study of the dynamics of different radiation induced chromosomal aberrations. Data here presented show that in G0 phase chromosome fragments lacking telomere signals (incomplete chromosome elements, ICE) show a slow repair, but when repair occurs tend to reconstitute the original chromosomes, and those that do not repair seem to be selected by interphase cell death and cell cycle checkpoints.

Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.

Objectives: S100A4 has been recently identified as an adipokine associated with insulin resistance (IR) in adult subjects with obesity. However, no data about its levels in children with obesity and only a few approaches regarding its potential mechanism of action have been reported. To obtain a deeper understanding of the role of S100A4 in obesity, (a) S100A4 levels were measured in prepubertal children and adult subjects with and without obesity and studied the relationship with IR and (b) the effects of S100A4 in cultured human adipocytes and vascular smooth muscle cells (VSMCs) were determined.

The Cytoscape BioGateway App: explorative network building from the BioGateway triple store.

Summary: The BioGateway App is a Cytoscape (version 3) plugin designed to provide easy query access to the BioGateway RDF triple store, which contains functional and interaction information for proteins from several curated resources. For explorative network building, we have added a comprehensive dataset with regulatory relationships of mammalian DNA binding transcription factors and their target genes, compiled both from curated resources and from a text mining effort. Query results are visualised using the inherent flexibility of the Cytoscape framework, and network links can be checked against curated database records or against the original publication.

Prognostic significance of albumin levels prior to treatment in patients with head and neck squamous cell carcinoma.

Introduction And Objectives: Pre-treatment albumin levels have been shown to have prognostic capacity in oncological patients. The aim of this study is to analyse the relationship between albumin levels and prognosis in patients with head and neck squamous cell carcinoma (HNSCC).

Methods: We performed a retrospective study in a cohort of 741 patients with HNSCC and a plasmatic albumin testing within the 4weeks prior to the start of treatment.

Life cycle assessment of carrier bags and development of a littering indicator.

Increased plastic consumption has resulted in high amounts of plastic waste ending up in the environment. Recently, the European Commission (EC) has identified a list of single-use plastics, including plastic bags, most commonly found in the European beaches. As a response, alternatives for plastic carrier bags have been more of a concern.

Laparoscopic sleeve gastrectomy induces molecular changes in peripheral white blood cells.

Background & Aims: Peripheral white blood cells (PWBC) may allow for the development of obesity biomarkers. We aimed to investigate the existence of gene expression and DNA methylation changes in PWBC after a very low calorie diet (VLCD) followed by a laparoscopic sleeve gastrectomy (LSG), and its correlation with surgical outcomes.

Methods: From July 2013 to June 2014, 35 consecutive bariatric patients and 33 healthy lean volunteers were recruited.