Publications by authors named "Pugh P"

Background Rapid treatment of ST-elevation myocardial infarction (STEMI) patients with primary percutaneous coronary intervention (PCI) significantly reduces morbidity and mortality rates. Recent studies emphasize the importance of reducing total ischemic time, making first-medical-contact-to-balloon (FMCTB) time a key performance indicator. To improve FMCTB times in patients brought to the Emergency Department (ED) by Emergency Medical Services (EMS), we implemented a "Direct to Lab" (DTL) workflow during the following conditions: weekday daytime hours, when the lab is fully staffed, and for hemodynamically stable STEMI patients presenting via EMS.

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Aims: Stroke is the most debilitating outcome of atrial fibrillation (AF). The use of implantable loop recorders increases the detection of AF episodes among patients with embolic stroke of undetermined source. The significance of device-detected AF, or subclinical AF, is unknown.

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Article Synopsis
  • Nutritional management is crucial for infants and toddlers with chronic kidney disease (CKD) to support growth and prevent developmental issues, extending through puberty when nutritional needs increase significantly.
  • Inadequate nutrition during childhood can hinder potential adult height and contribute to neurodevelopmental abnormalities, while obesity prevalence in CKD children highlights the need for effective nutritional strategies to combat metabolic syndrome.
  • The review emphasizes the importance of integrating clinical practice recommendations for managing the nutritional needs of children with CKD (ages 1-18) and advocates for collaboration between physicians and pediatric kidney dietitians to ensure tailored care for optimal growth and development.
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Background: Support groups for people with Implantable Cardioverter Defibrillators (ICDs) are widely used, however, it is not clear what people with ICDs gain from a support group or what format they should take.

Objectives: The aim of the present study is to define the perceived benefit of ICD support groups and develop practical recommendations for group format.

Methods: 14 individuals with ICDs were interviewed using a semi-structured interview guide.

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Background: An early dietary phosphate intervention (EPI) can provide vital medical benefits supporting self-management of chronic kidney disease (CKD) in childhood.

Objective: To utilise expert consensus to provide early modelling for an EPI to guide clinical practice across a paediatric renal network.

Methods: Forty-eight statements across six domains were constructed following a systematic review and semi-structured interviews with children and young people (CYP), parents and healthcare professionals (HCP).

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Cardiac resynchronisation therapy is ineffective in 30-40% of patients with heart failure with reduced ejection fraction. Targeting non-scarred myocardium by selecting the site of latest mechanical activation using echocardiography has been suggested to improve outcomes but at the cost of increased resource utilisation. The interval between the beginning of the QRS complex and the local LV lead electrogram (QLV) might represent an alternative electrical marker.

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Elevated right ventricular pacing (RVP) burdens are associated with the development of pacing-induced cardiomyopathy. This association is alluded to in the recent European and American pacing guidelines where anticipated pacing burden forms part of the indications for conduction system pacing. Understanding the temporal pattern of RVP burden is important with respect to anticipating future burden and ensuring that the most appropriate pacing modality is selected for patients.

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Aims: Atrial fibrillation (AF) is detected in over 30% of patients following an embolic stroke of undetermined source (ESUS) when monitored with an implantable loop recorder (ILR). Identifying AF in ESUS survivors has significant therapeutic implications, and AF risk is essential to guide screening with long-term monitoring. The present study aimed to establish the role of left atrial (LA) function in subsequent AF identification and develop a risk model for AF in ESUS.

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Background: Atrial fibrillation (AF) is the most common pathological arrhythmia, and its complications lead to significant morbidity and mortality. However, patients with AF can often go undetected, especially if they are asymptomatic or have a low burden of paroxysms. Identification of those at high risk of AF development may help refine screening and management strategies.

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Diabetes-related gastroparesis is a challenging complication of diabetes that often results in flares of intractable vomiting and recurrent hospitalizations. Currently, there is no standard of care or guidelines for the management of diabetes-related gastroparesis in the acute care setting, leading to inconsistent and suboptimal care for these patients. Consequently, patients with diabetes-related gastroparesis may have prolonged inpatient lengths of stay and frequent readmissions affecting their overall health and well-being.

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Introduction: There is growing interest in the prediction of incident atrial fibrillation (AF). The 12-lead electrocardiogram (ECG) has been a particularly rich target for possible prediction strategies.

Purpose: The P-wave axis is an ECG parameter that reflects the dominant vector of atrial depolarisation and is usually 0° -75°.

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Background: Patients with implantable cardioverter defibrillators (ICD) experience anxiety, depression and reduced quality of life (QoL).

Objectives: This mixed-methods systematic review evaluates whether ICD support groups have a beneficial effect on mental well-being.

Methods: Literature searches were carried out in MEDLINE, Embase, CINAHL, PsycINFO and Web of Science.

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Our objective was to systematically adapt Interrupting Prolonged sitting with ACTivity (InPACT), a classroom-based physical activity intervention, for home delivery to equitably increase access to structured youth physical activity opportunities during the COVID-19 pandemic. Key steps in the rapid-cycle research adaptation process included: (Step 1) identifying partner organizations; (Steps 2 and 3) engaging in problem and knowledge exploration to examine the problem from different perspectives; (Steps 4 and 5) initiating solution development and testing by selecting an intervention and adapting the format and content for home delivery. Using Rapid RE-AIM to guide online assessment and refinement of InPACT at Home; and (Step 6) utilizing dissemination strategies to extend the reach of the program.

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Background: Capnography has been associated with a reduced incidence of events related to respiratory compromise during procedural sedation.

Methods: A prospective service evaluation was conducted at a large United Kingdom (UK) teaching hospital to assess the impact of capnography on patient safety within four speciality services: bronchoscopy, endoscopy, interventional cardiology, and interventional radiology. Events were defined as provided by the World Society of Intravenous Anaesthesia.

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Since 2010, more than 50 UK fire deaths, have been reported as linked with emollients. This prompted the Medicines and Healthcare products Regulatory Agency (MHRA) to issue advice on their safer use in 2018. The advice was in response to concerns raised by the National Fire Chiefs Council, coroners' reports, and flammability tests.

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Background: Early dietary change can provide vital medical benefits supporting childhood chronic disease self-management.

Objective: To explore factors influencing the initiation of early dietary change in the management of childhood chronic disease, as described by children, parents', and other stakeholders, to inform practice change in early paediatric service delivery.

Methods: This systematic review crossed seven databases from 2000-2018 to identify empirical research (qualitative, quantitative, and mixed-method designs), including grey literature.

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In April 2014, a switch in the municipal water source for Flint, Michigan resulted in contamination of the water supply with lead, a toxic health hazard. Since the onset of this Flint Water Crisis, there has been considerable interest in behavioral health outcomes for Flint residents. In 2016, local, state, and federal partners began to collect household-level, emergency-related behavioral and physical health information in Flint.

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Two new deep-living species of the genus Bargmannia (Siphonophorae, Physonectae, Pyrostephidae) are described based, almost exclusively, on the nectophores of single specimens collected by ROVs off the west coast of California. The nectophores of B. stenotes sp.

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The siphonophore sub-order Cystonectae presently comprises just five species in three genera and two families, and includes Physalia physalis, the Portuguese Man O'War. Despite the smallness of the group its history has been very chequered, particularly for P. physalis, which has been described under more than fifty different names.

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In his Challenger Monograph Haeckel (1888b) listed a total of 204 species of siphonophores and 36 species of Porpitidae (Disconectae, according to Haeckel), which are now known not to belong to the Siphonophorae. In this paper the siphonophore species have been divided into four categories: a). species that had been described previously by an acknowledged authority other than Haeckel; b).

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