Publications by authors named "Pugatch R"

Finding the ground state of an Ising spin glass on general graphs belongs to the class of NP-hard problems, widely believed to have no efficient polynomial-time algorithms to solve them. An approach developed in computer science for dealing with such problems is to devise approximation algorithms; these are algorithms, whose run time scales polynomially with the input size, that provide solutions with provable guarantees on their quality in terms of the optimal unknown solution. Recently, several algorithms for the Ising spin-glass problem on a bounded degree graph that provide different approximation guarantees were introduced.

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Recently discovered simple quantitative relations, known as bacterial growth laws, hint at the existence of simple underlying principles at the heart of bacterial growth. In this work, we provide a unifying picture of how these known relations, as well as relations that we derive, stem from a universal autocatalytic network common to all bacteria, facilitating balanced exponential growth of individual cells. We show that the core of the cellular autocatalytic network is the transcription-translation machinery-in itself an autocatalytic network comprising several coupled autocatalytic cycles, including the ribosome, RNA polymerase, and transfer RNA (tRNA) charging cycles.

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We study airplane boarding in the limit of a large number of passengers using geometric optics in a Lorentzian metric. The airplane boarding problem is naturally embedded in a (1+1)-dimensional space-time with a flat Lorentzian metric. The duration of the boarding process can be calculated based on a representation of the one-dimensional queue of passengers attempting to reach their seats in a two-dimensional space-time diagram.

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Bacterial physiology is a branch of biology that aims to understand overarching principles of cellular reproduction. Many important issues in bacterial physiology are inherently quantitative, and major contributors to the field have often brought together tools and ways of thinking from multiple disciplines. This article presents a comprehensive overview of major ideas and approaches developed since the early 20th century for anyone who is interested in the fundamental problems in bacterial physiology.

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Thermodynamics places a limit on the efficiency of heat engines, but not on their output power or on how the power and efficiency change with the engine's cycle time. In this Letter, we develop a geometrical description of the power and efficiency as a function of the cycle time, applicable to an important class of heat engine models. This geometrical description is used to design engine protocols that attain both the maximal power and maximal efficiency at the fast driving limit.

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Bacterial self-replication is a complex process composed of many de novo synthesis steps catalyzed by a myriad of molecular processing units, e.g., the transcription-translation machinery, metabolic enzymes, and the replisome.

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Article Synopsis
  • - The study aimed to assess if model-based iterative reconstruction (MBIR) enhances diagnostic confidence and detection rates of pulmonary embolism (PE) during computed tomography pulmonary angiography, compared to hybrid iterative reconstruction (HIR) and filtered back projection (FBP) techniques.
  • - Fifty patients were evaluated, with each study reconstructed using FBP, HIR, and MBIR, and assessed by radiologists on various criteria, including diagnostic confidence and detection of PE, with results showing MBIR significantly improved PE detection and confidence levels compared to FBP and HIR.
  • - The study found that while accuracy rates were similar across the three methods, MBIR had a notably higher sensitivity for detecting PE, as well as subjective improvements in image
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We measure the statistics of phase locking levels of coupled fiber lasers with fluctuating cavity lengths. We found that the measured distribution of the phase locking level of such coupled lasers can be described by the generalized extreme value distribution. For large number of lasers the distribution of the phase locking level can be approximated by a Gumbel distribution.

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We determined the probability distribution of the combined output power from 25 coupled fiber lasers and show that it agrees well with the Tracy-Widom and Majumdar-Vergassola distributions of the largest eigenvalue of Wishart random matrices with no fitting parameters. This was achieved with 500,000 measurements of the combined output power from the fiber lasers, that continuously changes with variations of the fiber lasers lengths. We show experimentally that for small deviations of the combined output power over its mean value the Tracy-Widom distribution is correct, while for large deviations the Majumdar-Vergassola distribution is correct.

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It is experimentally demonstrated that perfect imaging is possible in disordered wave guiding media, provided that the disorder is off-diagonal, i.e., that only the spacing varies randomly between the otherwise identical lattice sites.

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Self-similar solutions of the coherent diffusion equation are derived and measured. The set of real similarity solutions is generalized by the introduction of a nonuniform phase, based on the elegant Gaussian modes of optical diffraction. In a light-storage experiment, the complex solutions are imprinted on a gas of diffusing atoms, and the self-similar evolution of both their amplitude and phase pattern is demonstrated.

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We study, theoretically and experimentally, an ensemble of two-level systems coupled to an environment which induces random jumps in their resonant frequency. We present a closed-form formula for the spectrum in terms of the resonant frequency distribution and the Poisson rate constant. For a normal distribution the spectrum deviates from a generalized Gumbel function, a well-known result for continuous stochastic Gaussian processes.

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We experimentally demonstrate electromagnetically induced transparency and light storage with ultracold 87Rb atoms in a Mott insulating state in a three-dimensional optical lattice. We have observed light storage times of approximately 240 ms, to our knowledge the longest ever achieved in ultracold atomic samples. Using the differential light shift caused by a spatially inhomogeneous far detuned light field we imprint a "phase gradient" across the atomic sample, resulting in controlled angular redirection of the retrieved light pulse.

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We report the observation of the signature of a localization phase transition for light in one-dimensional quasiperiodic photonic lattices, by directly measuring wave transport inside the lattice. Below the predicted transition point an initially narrow wave packet expands as it propagates, while above the transition expansion is fully suppressed. In addition, we measure the effect of focusing nonlinear interaction on the propagation and find it increases the width of the localized wave packets.

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We report an experiment that directly measures the Laplace transform of the recurrence probability in one dimension using electromagnetically induced transparency (EIT) of coherent atoms diffusing in a vapor cell filled with buffer gas. We find a regime where the limiting form of the complex EIT spectrum is universal and only depends on the effective dimensionality in which the random recurrence takes place. In an effective one-dimensional diffusion setting, the measured spectrum exhibits power-law dependence over two decades in the frequency domain with a critical exponent of 0.

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Reversible and coherent storage of light in an atomic medium is a promising method with possible applications in many fields. In this work, arbitrary two-dimensional images are slowed and stored in warm atomic vapor for up to 30 micros, utilizing electromagnetically induced transparency. Both the intensity and the phase patterns of the optical field are maintained.

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Article Synopsis
  • - Pulmonary alveolar proteinosis (PAP) can occur in a primary idiopathic form, primarily affecting middle-aged individuals, or due to factors like inhalation exposure, blood cancers, or immune issues, with tobacco use being a significant risk factor.
  • - Symptoms of PAP can range from mild breathlessness to severe respiratory failure, and a characteristic "crazy-paving" pattern is seen on CT scans, distinguishing it from other lung conditions.
  • - Diagnosis typically involves lung biopsy or bronchoalveolar lavage to find specific protein deposits, and while whole-lung lavage helps with symptoms, new therapies targeting immune deficiencies show moderate effectiveness.
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Rationale And Objectives: The purpose of this multicenter, multireader study was to evaluate the performance of computed tomography (CT) lung nodule computer-aided detection (CAD) software as a second reader.

Methods And Materials: The study involved 109 patients from four sites. The data were collected from a variety of multidetector CT scanners and had different scan parameters.

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We report an experiment in which an optical vortex is stored in a vapor of Rb atoms. Because of its 2pi phase twist, this mode, also known as the Laguerre-Gauss mode, is topologically stable and cannot unwind even under conditions of strong diffusion. For comparison, we stored a Gaussian beam with a dark center and a uniform phase.

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Pleuropulmonary synovial sarcoma (PPSS) is increasingly recognized as a subtype of sarcoma because of the recent identification of a distinctive chromosomal translocation specific to synovial sarcoma. Soft-tissue synovial sarcoma is far more common than PPSS and typically develops in para-articular locations of the extremities; affects young and middle-aged adults, with no difference in distribution between the sexes; and has well-documented radiologic manifestations. PPSS may arise in the chest wall, heart, mediastinum, pleura, or lung, and it shares patient demographics and several imaging features with its soft-tissue counterpart.

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Imaging plays an integral role in diagnosing, staging, and following patients with lung cancer. Many lung neoplasms are detected on chest radiographs, but the majority of patients have advanced stage disease at the time of presentation. There is a wide spectrum of radiologic manifestations of lung cancer, and recognition of these findings is essential for patient management.

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Lymphangioleiomyomatosis (LAM) is an uncommon interstitial lung disease that exclusively affects women, usually during their reproductive years. LAM is characterized pathologically by abnormal proliferation of LAM cells in the lungs and in thoracic and retroperitoneal lymphatics. Thirty-three cases of LAM were reviewed retrospectively for clinical and radiologic findings.

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