Publications by authors named "Pu-Gen An"
Article Synopsis
- - The study focused on evaluating the safety and effectiveness of combining tislelizumab (a PD-1 inhibitor) and nimotuzumab (an EGFR inhibitor) for treating recurrent or metastatic oral squamous cell carcinoma in patients with a poor ECOG performance status (PS score ≥ 2).
- - Results showed a median overall survival of 10.1 months and a 40% overall response rate, with some patients experiencing partial responses; most side effects reported were mild to moderate in severity.
- - The findings suggest that this combination therapy offers a promising low-toxicity option for patients with advanced oral squamous cell carcinoma, providing hope for better treatment outcomes in this challenging patient population.
Article Synopsis
- The text references a correction made to a previously published article, indicating that there may have been errors or necessary clarifications in the original paper.
- The DOI (Digital Object Identifier) provided is a unique identifier for the specific article, enabling easy access and citation.
- It signifies that the scientific community values accuracy and transparency in research publications.
Article Synopsis
- The study investigates the effectiveness of a combination treatment of neoadjuvant tislelizumab (a PD-1 inhibitor) and chemotherapy for patients with locally advanced oral or oropharyngeal squamous cell carcinoma (LAOOPSCC), aiming to improve surgical outcomes and survival rates.
- Out of 33 patients analyzed, the treatment led to a 66.7% response rate, with significant rates of major and complete pathological responses, indicating a promising approach to managing LAOOPSCC.
- The results suggest potential benefits in organ preservation and survival, although the authors recommend more extensive research to confirm these findings.
The primary objective of this study was to evaluate the safety of 810 and 1064 nm laser treatment on dental implants. Peri-implantitis is a challenge for clinicians and researchers. A pig mandible model was used to evaluate temperature increases during laser irradiation.
View Article and Find Full Text PDFAdenoid cystic carcinoma (ACC) is one of the most common malignancy of the major salivary glands with a high recurrence rate and poor prognosis. Determining tumor heterogeneity and factors in the microenvironment may provide novel therapeutic targets for ACC. We performed single-cell RNA sequencing of one ACC sample and normal salivary gland tissues from a patient to analyze tumor heterogeneity, immunosuppressive landscape, and intercellular communication networks.
View Article and Find Full Text PDFThe aim of this study was to investigate the underlying mechanisms of adenoid cystic carcinoma (ACC) at the transcriptome level. We obtained paired tumor and normal salivary gland tissues from 15 ACC patients, which were prepared for RNA sequencing. Gene enrichment analysis revealed that the upregulated pathways were mainly involved in axonogenesis, and the downregulated pathways were mainly related to leukocyte migration, the adaptive immune response, lymphocyte-mediated immunity, and the humoral immune response.
View Article and Find Full Text PDF[A Sampling Survey of the Oral Health Status and Awareness among Primary School Students in Lhasa].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
August 2021
Objective To investigate the oral health status and awareness of urban children in Lhasa,aiming to provide a data basis for the prevention and treatment of children's caries and the promotion of oral health education. Methods A total of 504 Tibetan students were selected by cluster sampling from 2 primary schools in Chengguan District of Lhasa.All the participants were required to take oral health examination and complete a questionnaire about oral health awareness and behavior.
View Article and Find Full Text PDFThe inferior alveolar nerve and facial nerve are the two most important nerves in the dental and maxillofacial region. The injury to them is one of the major postoperative complications after alveolar surgery and orthognathic surgery. However, recovering the nerve function after injury takes a long time and the recovery effect tends to be unsatisfactory.
View Article and Find Full Text PDF