Oxysophocarpine Prevents the Glutamate-Induced Apoptosis of HT-22 Cells via the Nrf2/HO-1 Signaling Pathway.

Oxysophocarpine (OSC), a quinolizidine alkaloid, shows neuroprotective potential, though its mechanisms are unclear. The aim of the present study was to investigate the neuroprotective effects of OSC through the nuclear factor erythroid 2-related factor 2 (Nrf2)/ heme oxygenase-1 (HO-1) signaling pathway using the HT-22 cell line. Assessments of cell viability were conducted utilizing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.

Spectroscopic and Theoretical Insights into H Activation on Uranium Monoxide: Homolytic H Cleavage Mediated by Intermediate OU(η-H).

Elucidating molecular-level interactions between dihydrogen (H) and uranium oxides reveals fundamental insights into the intrinsic H activation mechanisms underlying processes such as heterogeneous catalysis over uranium oxides and corrosion of uranium induced by H. Herein, the reactions of H with uranium monoxide (UO) molecules have been investigated via a combination of matrix-isolation infrared spectroscopy and quantum chemical calculations. A side-on bonded H complex, OU(η-H), is identified at 3733.

Current status and continuing medical education need for general practitioners in Tibet, China: a cross-sectional study.

Background: The Tibetan area is one of China's minority regions with a shortage of general practice personnel, which requires further training and staffing. This research helps to understand the current condition and demand for general practitioner (GP) training in Tibetan areas and to provide a reference for promoting GP education and training.

Methods: We conducted a cross-sectional survey using stratified sampling targeting 854 GPs in seven cities within the Tibetan Autonomous Region, utilizing an online questionnaire.

Beryllium Dimer Reactions with Acetonitrile: Formation of Strong Be-Be Bonds.

Laser ablated Be atoms have been reacted with acetonitrile molecules in 4 K solid neon matrix. The diberyllium products BeBeNCCH and CNBeBeCH have been identified by D and C isotopic substitutions and quantum chemical calculations. The stabilization of the diberyllium species is rationalized from the formation of the real Be-Be single bonds with bond distances as 2.

Regel Improves -Induced Inflammatory Responses in a Mouse Ear Edema Model and Suppresses Pro-Inflammatory Chemokine Production the MAPK and NF-κB Pathways in RAW264.7 Cells.

Background: Acne vulgaris (AV) is a common adolescent skin condition which is mainly caused by overcolonization and subsequent inflammation.

Objective: Our previous studies demonstrated that ethanol extracts of Regel (EMQ) possess significant antimicrobial properties. However, their protective effects and potential mechanisms against AV remain unclear.

Autumn migration of black-necked crane () on the Qinghai-Tibetan and Yunnan-Guizhou plateaus.

Despite previous research efforts, the majority migration routes of the black-necked cranes () have remained veiled. In this study, we utilized satellite telemetry data from 45 cranes between 2015 and 2021 to unveil critical insights. Our results revealed 11 distinct autumn migration routes and one sedentary flock, of which eight routes and the sedentary flock were previously undocumented.

CO Oxidation to CO on Uranium Dioxide Molecules through Intermediate OU(η-CO).

Investigations on the reactions of uranium oxide molecules with CO offer new inspiration for the design of promising high-efficiency catalysts for CO activation using actinide materials. Herein, we contribute a combined matrix-isolation infrared spectroscopic and theoretical study of CO oxidation to CO on uranium dioxide (UO) molecules in solid argon. The reaction intermediate OU(η-CO) is generated spontaneously at the bands of 1893.

Antibacterial activity and underlying mechanism of Meconopsis quintuplinervia Regel extract against the acne-causing bacteria Propionibacterium acnes and Staphylococcus aureus.

The aim of this study was to evaluate the antibacterial activity and underlying mechanism of ethanol extracts of Meconopsis quintuplinervia Regel (EMQ) against the acne-causing bacteria Propionibacterium acnes and Staphylococcus aureus. The study results indicated that EMQ was an effective antibacterial agent against P. acnes and S.

Dynamic detection of three-dimensional crop phenotypes based on a consumer-grade RGB-D camera.

Introduction: Nondestructive detection of crop phenotypic traits in the field is very important for crop breeding. Ground-based mobile platforms equipped with sensors can efficiently and accurately obtain crop phenotypic traits. In this study, we propose a dynamic 3D data acquisition method in the field suitable for various crops by using a consumer-grade RGB-D camera installed on a ground-based movable platform, which can collect RGB images as well as depth images of crop canopy sequences dynamically.

FBMF (M = B and Al) Molecules: A Matrix Infrared Spectra and Theoretical Calculations Investigation.

Reactions of laser-ablated B and Al atoms with BF have been explored in the 4 K excess neon through the matrix isolation infrared spectrum, isotopic substitutions and quantum chemical calculations. The inserted complexes FBMF (M = B, Al) were identified by anti-symmetric and symmetric stretching modes of F-B-F, and the F-B-F stretch modes are at 1336.9 and 1202.

C-O Bond Activation in Mononuclear Lanthanide Oxocarbonyl Complexes OLn(η-CO) (Ln = La, Ce, Pr, and Nd).

Fundamental investigation of metal-CO interactions is of great importance for the development of high-performance catalysts to CO activation. Herein, a series of side-on bonded mononuclear lanthanide (Ln) oxocarbonyl complexes OLn(η-CO) (Ln = La, Ce, Pr, and Nd) have been prepared and identified in solid argon matrices. The complexes exhibit uncommonly low C-O stretching bands near 1630 cm, indicating remarkable C-O bond activation in these Ln analogues.

Ethanol extract of Nepeta angustifoia C. Y. Wu ameliorates hyperuricemia in fructose-induced mice.

As a popular medicinal plant traditionally used in Tibet of China, Nepeta angustifolia C. Y. Wu is mainly administered to treat apoplexia, cerebral haemorrhage, fainting and epilepsy and other symptoms, while its effect on hyperuricemia is still unclear.

Matrix-Isolation Infrared Spectra and Electronic Structure Calculations for Dinitrogen Complexes with Uranium Trioxide Molecules UO(η-NN).

Investigations of the interactions of uranium trioxide (UO) with other species are expected to provide a new perspective on its reaction and bonding behaviors. Herein, we present a combined matrix-isolation infrared spectroscopy and theoretical study of the geometries, vibrational frequencies, electronic structures, and bonding patterns for a series of dinitrogen (N) complexes with UO moieties UO(η-NN). The complexes are prepared by reactions of laser-ablated uranium atoms with O/N mixtures or laser-ablated UO molecules with N in solid argon.

Insights into the Metal-CO Bond in OM(η-CO) (M = Cr, Mo, W, Nd, and U) Complexes.

Investigations on the structures and bonding properties of metal carbonyl compounds provide fundamental understandings on the origin of small-molecule activations. Herein, the geometry and bonding trends of a series of isovalent metal oxocarbonyl complexes OM(η-CO) (M = Cr, Mo, W, Nd, and U) were studied by combined matrix-isolation infrared spectroscopy and advanced quantum chemical calculations. The title complexes present red shift of C-O stretching bands in the range from 122 to 244 cm, indicating the difference of CO activation ability for the series of isovalent metal dioxides.

Small Intestine Bacterial Overgrowth in Bangladeshi Infants Is Associated With Growth Stunting in a Longitudinal Cohort.

Introduction: Small intestine bacterial overgrowth (SIBO) is common in children from low-income countries and has been cross-sectionally associated with growth stunting. We sought to determine whether SIBO was associated with poor growth and neurodevelopmental in a longitudinal analysis.

Methods: We measured SIBO by glucose hydrogen breath test (GHBT) at 18, 52, 78, and 104 weeks of life in a prospective longitudinal birth cohort of Bangladeshi children.

Evaluation of nanoscaled dual targeting drug-loaded liposomes on inhibiting vasculogenic mimicry channels of brain glioma.

Brain glioma is the most common primary tumour of the central nervous system. Complete surgical removal of the brain glioma is virtually impossible. Chemotherapy is still an important treatment for brain glioma.

Hepatoprotective effect of oorcroftiana (Benth.) Benth.Ex baker seeds and .

The leguminosae of (Benth.) Benth.ex Baker is a drought-resistant endemic Sophora shrub species from the Qinghai-Tibet Plateau, and its seeds have hepatoprotective effects.

Intermediates of Carbon Monoxide Oxidation on Praseodymium Monoxide Molecules: Insights from Matrix-Isolation IR Spectroscopy and Quantum-Chemical Calculations.

Identifying reaction intermediates in gas-phase investigations will provide understanding for the related catalysts in fundamental aspects including bonding interactions of the reaction species, oxidation states (OSs) of the anchored atoms, and reaction mechanisms. Herein, carbon monoxide (CO) oxidation by praseodymium monoxide (PrO) molecules has been investigated as a model reaction in solid argon using matrix-isolation IR spectroscopy and quantum-chemical calculations. Two reaction intermediates, OPr(η-CO) and OPr(η-CO), have been trapped and characterized in argon matrixes.

FBMF (M = V, Nb, and Ta) and FBMF (M = Nb and Ta): A Combined Matrix Isolation Infrared Spectroscopic and Quantum Chemical Investigation.

Through matrix isolation infrared spectrometry and quantum chemical calculations, the reactions of laser ablated V, Nb, and Ta with boron trifluoride were investigated in excess solid neon at 4 K. The possible reaction products FBMF, FBMF, and BMF (M = V, Nb, and Ta) were calculated at the B3LYP, BPW91, and CCSD(T) levels of theory. The B-M bond strength in FBMF molecules is confirmed by energy decomposition analysis-natural orbitals for chemical valence calculations, CASSCF calculation, and natural bond orbital analysis, which favors one σ bond and two half π bonds.

Gut microbiome communication with bone marrow regulates susceptibility to amebiasis.

The microbiome provides resistance to infection. However, the underlying mechanisms are poorly understood. We demonstrate that colonization with the intestinal bacterium Clostridium scindens protects from Entamoeba histolytica colitis via innate immunity.

Matrix infrared spectroscopy of FBMF and FB[triple bond, length as m-dash]WF (M = Cr, Mo and W) complexes and quantum chemistry calculations.

Laser-ablated group 6 transition metal atoms react with BF3 to yield typical transition metal inserted complexes F2B-MF (M = Cr, Mo, and W) and terminal borylene complex FB[triple bond, length as m-dash]WF2. These products are investigated by using infrared spectroscopy, isotopic substitution and theoretical frequency calculations. The inserted complexes F2B-MF (M = Cr, Mo, and W) were identified by antisymmetric and symmetric stretching modes of F-B-F.

Boron-Transition-Metal Triple-Bond FB≡MF Complexes.

The boron-transition-metal triple-bond complexes FB≡MF (M= Ir, Os, Re, W, Ta) were trapped in excess solid neon and argon through metal atom reactions with boron trifluoride and identified by matrix isolation infrared spectroscopy and quantum chemical calculations. The FB≡MF molecule features very high B-F stretching frequencies at 1586.6 cm (Ir), 1526.

Probing the Electronic Structure and Chemical Bonding of Uranium Nitride Complexes of NU-XO (X = C, N, O).

Uranium(III) compounds are very reactive and exhibit a broad range of chemical-bonding tendencies owing to the spatially diffused valence orbitals of uranium. A systematic study on the geometries, electronic structures, and chemical bonding of NU-XO (X = C, N, O) is performed using relativistic quantum chemistry approaches. The NU-CO and NU-NO complexes have an end-on structure, that is, (NU) (η-CO) and (NU) (η-NO), whereas NU-OO adopts a side-on ((NU) (η-O)) structure.

Fluoroborylene Complexes FBMF (M = Sc, Y, La, Ce): Matrix Infrared Spectra and Quantum Chemical Calculations.

Laser-ablated group 3 transition metal and cerium atom reactions with boron trifluoride were explored in excess solid neon at 4 K through matrix isolation infrared spectroscopy and quantum chemical calculations. The fluoroborylene complexes FBMF (M = Sc, Y, La, Ce) were trapped in inert gas and identified by the isotopic substitutions. The observed frequencies of FBMF were reproduced by DFT, NEVPT2, and CASSCF calculations.