Versatile Route To Fabricate Precious-Metal Phosphide Electrocatalyst for Acid-Stable Hydrogen Oxidation and Evolution Reactions.

Highly active catalyst for the hydrogen oxidation/evolution reactions (HOR and HER) plays an essential role for the water-to-hydrogen reversible conversion. Currently, increasing attention has been concentrated on developing low-cost, high-activity, and long-life catalytic materials, especially for acid media due to the promise of proton exchange membrane (PEM)-based electrolyzers and polymer electrolyte fuel cells. Although non-precious-metal phosphide (NPMP) catalysts have been widely researched, their electrocatalytic activity toward HER is still not satisfactory compared to that of Pt catalysts.

The transcriptomes from two adipocyte progenitor cell types provide insight into the differential functions of MSTN.

Myostatin (MSTN) was previously shown to differentially regulate the adipogenesis of adipose-derived stem cells (ADSCs) and muscle satellite cells (MSCs), both of which can serve as progenitor cells for intramuscular adipocytes. We previously showed that MSTN mediates the differential regulation of MyoD and PPARγ in ADSCs and MSCs. Here, we analyzed the effects of MSTN on whole-transcriptome expression profiles of ADSCs and MSCs, revealing that MSTN differentially regulates ADSCs and MSCs, with MSCs being more responsive to MSTN treatment.

Multi-View Mammographic Density Classification by Dilated and Attention-Guided Residual Learning.

Breast density is widely adopted to reflect the likelihood of early breast cancer development. Existing methods of mammographic density classification either require steps of manual operations or achieve only moderate classification accuracy due to the limited model capacity. In this study, we present a radiomics approach based on dilated and attention-guided residual learning for the task of mammographic density classification.

Combustion of lean methane over CoO catalysts prepared with different cobalt precursors.

To investigate the effect of catalyst precursors on physicochemical properties and activity of lean methane catalytic combustion, a series of CoO catalysts were prepared a precipitation method by using four different cobalt precursors: Co(CHO), Co(NO), CoCl, and CoSO. The catalysts were characterized by BET, XRD, SEM, Raman, XPS, XRF, O-TPD and H-TPR techniques. It was found that the different types of cobalt precursor had remarkable effects on the surface area, particle size, reducibility and catalytic performance.

A novel G1202A mutation in a Chinese patient with pure adrenomyeloneuropathy and literature review.

Adrenomyeloneuropathy (AMN) is a kind of varied disease caused by gene mutation and characterized by very-long-chain fatty acids (VLCFA) accumulation. It is diagnosed by clinical features, high VLCFAs levels and gene mutation. AMN is rarely reported in Chinese population.

Association between Aldose Reductase Gene C(-106)T Polymorphism and Diabetic Retinopathy: A Systematic Review and Meta-Analysis.

Controversial results regarding the associations between aldose reductase (AR) genetic polymorphisms and diabetic retinopathy (DR) have been reported for many years. The present meta-analysis was performed to clarify the effects of the AR gene C(-106)T polymorphism on DR risk. The PubMed, Web of Sciences, Cochrane library, EMBASE, Chinese National Knowledge Infrastructure, and Wan Fang databases were extensively searched in Chinese to select relevant studies with an updated date of April 25, 2018.

Regulation of serum lipidomics and amino acid profiles of rats with acute myocardial ischemia by Salvia miltiorrhiza and Panax notoginseng herb pair.

Background: Salvia miltiorrhiza and Panax notoginseng herb pair (DQ) has been widely used in traditional Chinese medicine for a long history to prevent and treat the coronary heart disease. However, its protective mechanisms against myocardial ischemia during coronary heart disease remain not well-understood.

Purpose: In this study, we aimed to explore the protective mechanisms of DQ on myocardial ischemia from the perspective of serum lipidomics and amino acids (AAs).

Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1.

This study aimed to investigate the therapeutic effect of the mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) on diffuse large B-cell lymphoma (DLBCL) and its underlying molecular mechanism through the application of Z-Val-Arg-Pro-DL-Arg-fluoromethyl ketone (Z-VRPR-FMK). Cultured OCI-LY10 cells and their xenografts in nude mice were treated with Z-VRPR-FMK. The growth and invasiveness of the tumor were observed.

Single-Atom Catalysts for Electrochemical Hydrogen Evolution Reaction: Recent Advances and Future Perspectives.

Hydrogen, a renewable and outstanding energy carrier with zero carbon dioxide emission, is regarded as the best alternative to fossil fuels. The most preferred route to large-scale production of hydrogen is by water electrolysis from the intermittent sources (e.g.

The first two cases of transcatheter mitral valve repair with ARTO system in Asia.

Background: MAVERIC (Mitral Valve Repair Clinical Trial) validates the safety and efficacy of the ARTO system. We here report the first two successful cases of utilizing the ARTO system in patients with symptomatic heart failure (HF) with functional mitral regurgitation (FMR) in Asia.

Methods: Two patients, aged 70 and 63, had severe HF with FMR.

Antioxidative and antiapoptosis: Neuroprotective effects of dauricine in Alzheimer's disease models.

Aims: Dauricine has been found that has significant neuroprotective effect on Alzheimer's disease (AD), but the mechanism is unclear, so we further investigated the possible mechanism of dauricine on AD.

Main Methods: Cell counting kit-8 (CCK8) was applied to measure the cytotoxicity of dauricine on SH-SY5Y cells that overexpress the Swedish mutant form of human β-amyloid precursor protein (APPsw) and control cells (Neo). We used the Cu to induce oxidative damage on APPsw cells, then tested the effect of dauricine on the damage and relative factors including reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and superoxide dismutase (SOD) activity.

Trace element distribution in tissues and risk of exposure of ruddy shelduck wintering in Nanhaizi Wetland, Baotou, China.

The Nanhaizi Wetland (NHZW) is a significant part of the Baotou Yellow River National Wetland Park in China, an important migration station and habitat for waterfowl. The Yellow River receives a significant amount of industrial and agricultural wastewater. Therefore, the environmental quality of NHZW directly affects the survival of migratory birds in the Baotou region.

Omadacycline Efficacy against Enterococcus faecalis Isolated in China: Activity, Heteroresistance, and Resistance Mechanisms.

This study aimed to evaluate the antimicrobial activity, heteroresistance emergence, and resistance mechanism of omadacycline (OMC) in clinical isolates from China. A total of 276 isolates were collected retrospectively in China from 2011 to 2015. The MICs of OMC, doxycycline (DOX), and minocycline (MIN) against were determined by broth microdilution.

Correction to: miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit+ cells to promote proliferation and inhibit apoptosis through a negative feedback loop.

After publication of our article [1] we became aware that there were errors in Fig. 5b and Fig. 6c, namely that the immunofluorescence of EDU-positive cells of the CABLES1 transfection group in Fig.

The Combination of MoS/WO and Its Adsorption Properties of Methylene Blue at Low Temperatures.

It was found previously that neither monomer MoS nor WO is an ideal material for the adsorption of organic dyes, while MoS/WO composites synthesized by a two-step hydrothermal method have outstanding adsorption effects. In this work, the chemical state of each element was found to be changed after combination by X-ray photoelectron spectroscopy analysis, which lead to their differences in adsorption performance. Moreover, the adsorption test of methylene blue on MoS/WO composites was carried out under a series of temperatures, showing that the prepared composites also had appreciable adsorption rates at lower temperatures.

Fluorescent carbon quantum dots synthesized using phenylalanine and citric acid for selective detection of Fe ions.

A facile, economical and one-step hydrothermal method was used to synthesize fluorescent carbon dots by utilizing citric acid as carbon source and phenylalanine to provide nitrogen. The as-prepared fluorescence carbon dots had strong blue light emission around 440 nm. As confirmed by UVvis absorption, X-ray photoelectron spectroscopic, Fourier transform infrared spectroscopy and transmission electron microscope characterization, the carbon dots were small and very stable in water for using as a fluorescent probe.

Effect of fosinopril on the renal cortex protein expression profile of Otsuka Long-Evans Tokushima Fatty rats.

Angiotensin-converting enzyme inhibitors (ACEIs) can reduce urinary protein excretion and postpone the deterioration of renal function. However, the mechanisms of renal protection are not yet fully understood. To investigate the mechanisms of ACEIs in the treatment of diabetic nephropathy (DN), the present study determined the effects of the ACEI fosinopril (FP) on the profiling of renal cortex protein expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats using Long-Evans Tokushima Otsuka (LETO) rats as controls.

MicroRNA-497-5p Induces Cell Cycle Arrest Of Cervical Cancer Cells In S Phase By Targeting CBX4.

Purpose: miR-497-5p can inhibit cervical cancer cell proliferation. However, the underlying mechanism remains to be elucidated.

Methods: Bioinformatics was used to analyze the target genes of miR-497-5p.

The production of wheat - 1S chromosome substitution lines harboring alien novel high-molecular-weight glutenin subunits.

In our previous work, a novel high-molecular-weight glutenin subunit (HMW-GS) with an extremely large molecular weight from was identified that may contribute to excellent wheat () processing quality and increased dough strength, and we further generated HMW-GS homozygous lines by crossing. In this study, we crossed the HMW-GS homozygous line 66-17-52 with 'Chinese Spring' Ph1 mutant CS to induce chromosome recombination between wheat and . SDS-PAGE was used to identify 19 derived F lines with the HMW-GSs of .

Double Metal Diphosphide Pair Nanocages Coupled with P-Doped Carbon for Accelerated Oxygen and Hydrogen Evolution Kinetics.

Developing efficient and durable bifunctional transition metal phosphide (TMP) electrocatalysts is still a great challenge because of its relatively sluggish kinetics of oxygen evolution reaction (OER). Herein, we report a unique bimetallic diphosphide pair (FeP-NiP) forming spherical nanocages encapsulated in P-doped carbon layers (FeP-NiP@PC) as advanced bifunctional electrocatalyst synthesized by a very facile phosphorization approach. The obtained FeP-NiP@PC electrocatalyst exhibits an outstanding OER activity with an ultralow overpotential of 248 mV in 1 M KOH and a low overpotential of 117 mV for HER in 0.

Acute glycemic variability on admission predicts the prognosis in hospitalized patients with coronary artery disease: a meta-analysis.

Purpose: Increased glycemic variability has been related with poor prognosis in patients with coronary artery disease (CAD). However, whether diabetic status or subtype of CAD could affect the association remains unknown. We performed a meta-analysis to systematically evaluate the association between the mean amplitude of glycemic excursions (MAGE) on continuous glucose monitoring and the incidence of major adverse cardiovascular events (MACEs) in CAD patients.

Melatonin-Nitric Oxide Crosstalk and Their Roles in the Redox Network in Plants.

Melatonin, an amine hormone highly conserved during evolution, has a wide range of physiological functions in animals and plants. It is involved in plant growth, development, maturation, and aging, and also helps ameliorate various types of abiotic and biotic stresses, including salt, drought, heavy metals, and pathogens. Melatonin-related growth and defense responses of plants are complex, and involve many signaling molecules.

Sticker Microfluidics: A Method for Fabrication of Customized Monolithic Microfluidics.

This paper proposes a novel strategy and an all-in-one toolbox that allows instrument-free customization of integrated microfluidic systems. Unlike the modular design of combining multiple microfluidic chips in the previous literature, this work, for the first time, proposes a "template sticker" method, in which sacrificial templates for microfluidic components are batch-produced in the form of standardized stickers and packaged into a toolbox. To create a customized monolithic microfluidic system, the end users only need to select and combine various template stickers following formulated steps.

Inkjet Pattern-Guided Liquid Templates on Superhydrophobic Substrates for Rapid Prototyping of Microfluidic Devices.

This paper presents a novel method of rapidly customizing microfluidic systems using a consumer-grade inkjet printer and a commercially available superhydrophobic spray. By casting polydimethylsiloxane (PDMS) on liquid templates that are defined by inkjet-printed hydrophilic patterns on superhydrophobically-coated PDMS substrates, microfluidic devices can be directly fabricated. Utilizing the interfacial properties of the superhydrophobic coating and the template liquid, the fabrication of microfluidics could be done with minimum effort and expertise, and unlike previously reported works, no mask and bonding process is necessary.

Mutation of the d-hordein gene by RNA-guided Cas9 targeted editing reducing the grain size and changing grain compositions in barley.

In this study, we successfully knock-out the d-hordein component of barley storage protein using RNA-guided Cas9. Mutation frequencies of 25% and 14% at two different target sites were obtained. Homozygous mutant plants that were T-DNA free were identified in the T generation.