Predicting surface soil pH spatial distribution based on three machine learning methods: a case study of Heilongjiang Province.

Comprehensive and accurate acquisition of surface soil pH spatial distribution information is essential for monitoring soil degradation and providing scientific guidance for agricultural practices. This study focused on Heilongjiang Province in China, utilizing data from 125 soil survey sampling points. Key environmental covariates were identified as modeling inputs through Pearson correlation analysis and recursive feature elimination (RFE).

Application of chest wall perforator flaps in oncoplastic breast-conserving surgery.

Objective: This study aims to explore the application value of chest wall perforator flaps (CWPF) in oncoplastic breast-conserving surgery.

Methods: A retrospective review was conducted on 22 early-stage breast cancer patients who underwent oncoplastic breast-conserving surgery using CWPF between January 2021 and December 2022. This included 4 cases (18.

Design of Intrinsic Transparent Conductors from a Synergetic Effect of Symmetry and Spatial-Distribution Forbidden Transitions.

Intrinsic transparent conductors (ITCs) correspond to a unique class of TCs that do not need intentional doping. This character can provide ITCs significant advantages by avoiding severe "doping bottlenecks" and dopant scattering usually encountered in conventional transparent conducting oxides (TCOs). However, the realization of ITCs generally requires the minimization of photon absorption and reflection in metallic conductors, which is difficult due to the gapless nature of their band structures.

Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis.

Ovarian cancer (OC) is prone to peritoneum or omentum dissemination, thus giving rise to the formidable challenge of unresectable surgery and a dismal survival rate. Although niraparib holds a pivotal role in the maintenance treatment of OC, its effect on suppressing metastases during primary intervention remains enigmatic. Recently, we initiated a prospective clinical study (NCT04507841) in order to evaluate the therapeutic efficacy of neoadjuvant niraparib monotherapy for advanced OC with homologous recombination deficiency.

The smallest plant from the Lower Devonian of South China and the divergent life-history strategies in zosterophyllopsids.

Plants have evolved different life-history strategies to overcome limited amounts of available resources; however, when and how divergent strategies of sexual reproduction evolved in early land plants are not well understood. As one of the notable and vital components of early terrestrial vegetation, the Zosterophyllopsida and its type genus reached maximum species diversity during the Pragian (Early Devonian; 410.8-407.

Regulating Interfacial Hydrogen-Bonding Networks by Implanting Cu Sites with Perfluorooctane to Accelerate CO Electroreduction to Ethanol.

Efficient CO electroreduction (CORR) to ethanol holds promise to generate value-added chemicals and harness renewable energy simultaneously. Yet, it remains an ongoing challenge due to the competition with thermodynamically more preferred ethylene production. Herein, we presented a CO reduction predilection switch from ethylene to ethanol (ethanol-to-ethylene ratio of ~5.

Nonlinear optical properties of BiSeTe for harmonic mode-locked and broadband Q-switched pulses generation.

The nonlinear optical properties of bismuth selenium telluride (BiSeTe), a few-layer two-dimensional topological insulator material, have been investigated in this work. An erbium-doped fiber laser (EDFL) based on BiSeTe (BST) nanosheets as saturable absorber (SA) was demonstrated. The BST SA with saturation intensity and modulation depth of 4.

A rotational ellipsoid model for solid Earth tide with high precision.

Solid Earth tide represents the response of solid Earth to the lunar (solar) gravitational force. The yielding solid Earth due to the force has been thought to be a prolate ellipsoid since the time of Lord Kelvin, yet the ellipsoid's geometry such as major semi-axis's length, minor semi-axis's length, and flattening remains unresolved. Additionally, the tidal displacement of reference point is conventionally resolved through a combination of expanded potential equations and given Earth model.

A comprehensive study on Mecanum wheel-based mobility and suspension solutions for intelligent nursing wheelchairs.

Intelligent nursing wheelchairs significantly enhance mobility and independence for elderly individuals with disabilities. However, traditional designs often suffer from large turning radii that restrict their functionality in confined spaces. Addressing this critical challenge, this study introduces an innovative design utilizing a Mecanum wheel chassis that allows for omnidirectional movement, significantly improving maneuverability and stability.

Uncertainty propagation from probe spacing to Fourier 3-probe straightness measurement.

Reliable and precise straightness profile measurements are crucial for manufacturing ultra-precision components and are capable of further enhancing their accuracy. The Fourier three-probe (F3P) straightness measurement allows for precise assessment of the workpiece profile on the machine by eliminating the harmful influence of the error motion of the sliding table. However, the probe spacing uncertainty deteriorates the measurement accuracy remarkably; and, the affecting mechanism behind this phenomenon has not yet been studied in detail.

Efficient CO electroreduction to ethanol enabled by tip-curvature-induced local electric fields.

Electrocatalytic reduction of CO into multicarbon (C) products offers a promising pathway for CO utilization. However, achieving high selectivity towards multicarbon alcohols, such as ethanol, remains a challenge. In this work, we present a novel CuO nanoflower catalyst with engineered tip curvature, achieving remarkable selectivity and efficiency in the electroreduction of CO to ethanol.

Colonic epithelial cell-specific TFEB activation: a key mechanism promoting anti-bacterial defense in response to infection.

Colitis caused by infections, especially , has long been a common disease, underscoring the urgency to understand its intricate pathogenicity in colonic tissues for the development of effective anti-bacterial approaches. Of note, colonic epithelial cells, which form the first line of defense against bacteria, have received less attention, and the cross-talk between epithelial cells and bacteria requires further exploration. In this study, we revealed that the critical anti-bacterial effector, TFEB, was primarily located in colonic epithelial cells rather than macrophages.

Measurement of the Earth Tides with a Diamagnetic-Levitated Micro-Oscillator at Room Temperature.

The precise measurement of the gravity of Earth plays a pivotal role in various fundamental research and application fields. Although a few gravimeters have been reported to achieve this goal, miniaturization of high-precision gravimetry remains a challenge. In this work, we have proposed and demonstrated a miniaturized gravimetry operating at room temperature based on a diamagnetic levitated micro-oscillator with a proof mass of only 215 mg.

Identification and verification of diagnostic biomarkers based on mitochondria-related genes related to immune microenvironment for preeclampsia using machine learning algorithms.

Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality worldwide. Preeclampsia is linked to mitochondrial dysfunction as a contributing factor in its progression. This study aimed to develop a novel diagnostic model based on mitochondria-related genes(MRGs) for preeclampsia using machine learning and further investigate the association of the MRGs and immune infiltration landscape in preeclampsia.

A difficulty-aware and task-augmentation method based on meta-learning model for few-shot diabetic retinopathy classification.

Background: Accurate classification techniques are essential for the early diagnosis and treatment of patients with diabetic retinopathy (DR). However, the limited amount of annotated DR data poses a challenge for existing deep-learning models. This article proposes a difficulty-aware and task-augmentation method based on meta-learning (DaTa-ML) model for few-shot DR classification with fundus images.

NMDAR activation attenuates the protective effect of BM-MSCs on bleomycin-induced ALI via the COX-2/PGE pathway.

N-methyl-d-aspartate (NMDA) receptor (NMDAR) activation mediates glutamate (Glu) toxicity and involves bleomycin (BLM)-induced acute lung injury (ALI). We have reported that bone marrow-derived mesenchymal stem cells (BM-MSCs) are NMDAR-regulated target cells, and NMDAR activation inhibits the protective effect of BM-MSCs on BLM-induced pulmonary fibrosis, but its effect on ALI remains unknown. Here, we found that Glu release was significantly elevated in plasma of mice at d 7 after intratracheally injected with BLM.

Dynamics of abdominal symptoms during the start of a new therapy with elexacaftor/tezacaftor/ivacaftor using the novel CFAbd-day2day questionnaire.

Elexacaftor-tezacaftor-ivacaftor (ETI) is a novel, highly effective CFTR modulator combination proven to enhance lung function and body weight in people with cystic fibrosis (pwCF) carrying a F508del mutation. Recently, we revealed significant reductions in abdominal symptoms (AS) in German, British, and Irish pwCF after 24-26 weeks of ETI using the CFAbd-Score, the first patient-reported outcome measure (PROM) specifically developed and validated for pwCF following FDA guidelines. Notably, many pwCF reported marked changes in their AS during the first days of the new treatment.

Susceptibility of bovine to SARS-CoV-2 variants of concern: insights from ACE2, AXL, and NRP1 receptors.

The possibilities of cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between humans and important livestock species are not yet known. Herein, we used the structural and genetic alignment and surface potential analysis of the amino acid (aa) in angiotensin-converting enzyme 2 (ACE2), tyrosine kinase receptor UFO (AXL), and neuropilin 1 (NRP1) in different species with substantial public health importance. The residues interfacing with the N-terminal domain (NTD) or receptor-binding domain (RBD) of S were aligned to screen the critical aa sites that determined the susceptibility of the SARS-CoV-2 to the host.

Prediction of nonlayered oxide monolayers as flexible high-κ dielectrics with negative Poisson's ratios.

During the last two decades, two-dimensional (2D) materials have been the focus of condensed matter physics and material science due to their promising fundamental properties and (opto-)electronic applications. However, high-κ 2D dielectrics that can be integrated within 2D devices are often missing. Here, we propose nonlayered oxide monolayers with calculated exfoliation energy as low as 0.

A novel reconstruction method combining multi-detector SPECT with an elliptical orbit and computer tomography for cardiac imaging.

The myocardial single photon emission computed tomography (SPECT) is a good study due to its clinical significance in the diagnosis of myocardial disease and the requirement for improving image quality. However, SPECT imaging faces challenges related to low spatial resolution and significant statistical noise, which concerns patient radiation safety. In this paper, a novel reconstruction system combining multi-detector elliptical SPECT (ME-SPECT) and computer tomography (CT) is proposed to enhance spatial resolution and sensitivity.

Emerging SARS-CoV-2 variants of concern potentially expand host range to chickens: insights from AXL, NRP1 and ACE2 receptors.

Background: The possibilities of cross-species transmission of SARS-CoV-2 variants of concern (VOCs) between humans and poultry species are unknown. The analysis of the structure of receptor was used to investigate the potential of emerging SARS-CoV-2 VOCs to expand species tropism to chickens based on the interaction between Spike (S) protein and tyrosine kinase receptor UFO (AXL), angiotensin-converting enzyme 2 (ACE2), and neuropilin 1 (NRP1) with substantial public health importance.

Methods: The structural and genetic alignment and surface potential analysis of the amino acid (aa) in ACE2, AXL, and NRP1 in human, hamster, mouse, mink, ferret, rhesus monkey and chickens were performed by Swiss-Model and pymol software.