[A model of the computer-assisted morphological diagnosis of special forms of glomerulonephritis].

Computer morphological examination may reveal a predominant type of glomerulonephritis (GN) and, hence, establish the validity of diagnostical signs for other facultative forms of GN. This may be of importance for the therapy and prognosis.

[Use of the computer class DVK-KUVT-86 for programmed second level control with respect to pathology].

The paper deals with some experience in the programmed control of students' knowledge by constructed tests of the 2nd level using computers. According to the authors this method facilitates the development of independent logical students' thinking.

[Problem of the relationship of probable and real ecologic pathology].

Ecology plays more and more important role as an etiological factor of human diseases: congenital defects, tumours, immunodyzergies, hematopoietic and endocrine disorders. Two directions should be taken into consideration in establishing the role of ecology in human disease: pathology itself and ecogenic factor. The first one consists of the complex "populations at risk-pattern of mortality-ecogenic diseases, the second direction is "geography of potentially ecogenic diseases-correlation with geography of environmental pollution-eco-etiological factor".

[Knowledge of general pathologic anatomy in 5th-year students].

Students of the 5th year rather well retain their knowledge of the pathologic anatomy obtained during the 3rd year although their mean indices are relatively low. The index of student efficiency may be used for the improvement of teaching and for the student specialization in pathology.

[The use of the class of KUVT-86 computers for examination of pathologic anatomy].

Examination in pathology with a test control of the theoretical part is carried out with the use of the computer class KUVT-86. The degree of knowledge is evaluated by means of the 1st level test. A student receives 3 tickets for general, special and specific pathology, respectively.

[Application of the microcomputer "Electronika BK-0010" in programmed monitoring of the degree of students' assimilation of a course in pathologic anatomy according to tests at the first level].

To optimize the programmed checking of the students' knowledge on pathological anatomy, it is feasible to use an "Elektronika BK-0010" microcomputer. In terms of the limited internal storage of the computer, a package of questions and answers to them is recorded on a magnetic tape, the microcomputer being loaded with it before each study. For maximal employment of the microcomputer's internal storage, it is expedient to use the programs based on the combined application of a text in the form of questions and computer-assisted processing of the students answers.

[Formation of ion channels in the Escherichia coli cytoplasmic membrane after exposure to bacteriophages T4 and lambda].

The effects of phage T4 and lambda on the ion permeability of the E. coli cytoplasmic membrane were studied. It was shown that the phage-induced depolarization of the membrane is coupled with a simultaneous increase in a transmembrane pH gradient.

[Electron microscopy study of pathological collagen fibril formation in systemic scleroderma].

Electron microscopy of the skin biopsies from patients with systemic sclerodermia revealed the pathologic alterations of cellular and intracellular structures. The disease is characterized by focal lysis of nuclear, organoid and cytoplasmic membranes of the fibroblastic cells with the most essential alteration of cell plasmalemma. The cellular fragments (parts of cytoplasma, cisterns of the rough endoplasmic reticulum, mitochondria, nuclear debris) are found between the extracellular bundles of collagen fibrils.

[Formation of collagen fibrils in the synovial membrane in rheumatoid arthritis (electron microscope study)].

As demonstrates investigation of the synovial membrane biopsies obtained in patients suffering from rheumatoid arthritis, excessive formation of collagenous fibrillae results from participation, in this process, of activated synoviocytes B, pericytes and fibroblasts capable to intensify secretion and synthesis of tropocollagen. Aggregation of tropocollagen molecules into the collagenous fibrillae occurs in the areas where the inflammation acquires a chronic form where the cellular detritus is accumulated and where immune complexes are deposited. In the places mentioned, together with assembling normal collagenous fibrillae certain pathological fibrillar forms are observed, such as: fibrillae with an increased diameter, fibrillae with a changeable optic density of transversal streakness, those deprived of it, as well as segmentary scrap of fibrillo-formation.

[Ultrastructure of activation of connective and lymphoid tissue cells during experimental infectious-allergic carditis].

As a result of multiple and long-term antigenic stimulation with streptococcal products in experimental infectious-allergic carditis (EIAC) in rabbits there occurs functional activation of young connective-tissue cells of the cardiac valve, endothelial and perithelial cells of myocardium vessels and cells of the lymphoid tissue. Enhanced secretion of tropocollagen is common for mesenchymal heart cells in EIAC. At that, the most marked fibrillogenesis is observed in the cardiac valve in which tropocollagen is aggregated into mature fibrillae.

[Study of the total nucleic acid content of lymphoid tissue plasma cells for assessing the immunodepressive action of various antirheumatic agents].

The influence of antirheumatic drugs, acetylsalicylic acid, diacetoxibenzoic acid, imurane and D-penicillamine, on the status of immunocompetent cells in experimental infectious-allergic carditis was studied morphologically in 70 rabbits. The immunosuppressive effect of all 4 drugs was established which was manifested by a decrease in the number of plasma cells in the lymphoid tissue and a decrease in the content of nucleic acids in their cytoplasm. D-penicillamine was the exception as after its use the content of nucleic acids in the cell cytoplasm was found to be increased which was considered to be due to clasmatosis of plasma cells, marginal karyolysis, damage of the nuclear membrane and release of nucleic acids from the nucleus into the cytoplasm.