Controlled nanostructures formation on stainless steel by short laser pulses for products protection against falsification.

The coloration of stainless steel surface due to the formation of spatially periodic structures induced by laser pulses of nanosecond duration is demonstrated. The period of microstructures corresponds to the laser wavelength, and their orientation angle depends on the adjustment of laser polarization. The marking algorithm for the development of authentication patterns is presented.

[Objective method to recognize warning signs in peripheral vitreoretinal dystrophies].

Aim: to compare the effectiveness of biomicroscopy (BMS) and optical coherence tomography (OCT) in recognizing prognostically unfavorable signs in peripheral vitreoretinal dystrophy (PVRD) patients.

Material And Methods: A total of 131 cases of equatorial PVRD (91 eyes of 56 patients) were assessed. The mean patient's age was 24.

[A comparative study of Coxiella burnetii strains differing in virulence in the intratracheal infection of guinea pigs].

As found out in earlier investigations, after the intratracheal infection of guinea pigs with C. burnetii (the method of infection, most similar to aerogenic infection which is characteristic of Coxiella under natural conditions) the maximum amount of the infective agent is accumulated in the lungs of the animals, damaging the organs of the reticuloendothelial system. The present investigation has revealed that this method of infection makes it possible differentiate C.

[Preparation of hyperimmune horse serum against Ebola virus].

Immunization of horses with Ebola virus resulted in production of specific virus-neutralizing antibodies with their maximal level attained on days 28 to 42 postimmunization. Repeated cycles of immunization lead to increase of antibodies titer to 1:4096.

[The isolation of hyperimmune horse serum to the Ebola virus].

Immunization of horses with Ebola virus resulted in the production of specific virus-neutralizing antibody with maximum titres at 28-42 days. Repeated cycles of immunization led to a rise in antibody titres to 1:4096.

[A method of fluorescent immunoenzyme analysis in the complex evaluation of viral and rickettsial vaccines].

With the use of the unified indirect solid-phase fluorescent enzyme immunoassay the combined evaluation of the antigenic and immunogenic properties of experimental whole-virion inactivated virus vaccines against Venezuelan and eastern equine encephalomyelitides, as well as of dried chemical typhus vaccine, has been made; their safety was determined indirectly by the content of ovalbumin. The protective role of antibodies evaluated by the solid-phase fluorescent enzyme immunoassay in typhus immunity has been shown.

[A trial to produce an inactivated Lassa fever vaccine].

A single and double immunization of Papio hamadryas monkeys with an inactivated concentrated purified adsorbed preparation of Lassa virus in doses of 0.5-1.0 and 1.

[The immunomodulating action of interferons in their combined use with a typhus vaccine].

The data of the comparative study of the immunomodulating action of donor interferon and reaferon in experiments with typhus vaccine, used as an experimental model, on monkeys of different species and guinea pigs are presented. One of the main properties of interferons, besides their antiviral activity, is their capacity for producing an immunomodulating effect.

[The effect of the peroxidation of ribamidil-containing liposomes on the results of chemotherapy in experimental viral infections].

A relationship between ribamydil concentration and the intensity of accumulation of peroxidation products was found while storing ribamydil-containing liposomes which indicated a significant pro-oxidant activity of ribamydil. Increasing lethality of guinea pigs and white mice infected with Venezuelan equine encephalomyelitis virus was shown while using liposomal ribamydil containing from 4.78 to 6.

[A comparative evaluation of an immunoenzyme analytical method using a fluorogenic or chromogenic substrate in determining the Marburg virus antigen].

A comparative evaluation of the developed variants of indirect solid-phase enzyme immunoassay using fluorogenic and chromogenic substrates for the determination of Marburg virus antigen was carried out. The resolving capacity of this method was 3.8 x 10(-9) g of protein for the former and 3.

[The pathogenesis of Q fever in the intratracheal infection of guinea pigs].

The intratracheal introduction of R. burnetii is the method of infection, highly similar to aerogenic infection, the most widespread route of R. burnetii infection in humans under natural conditions.

[An experimental study of the contact transmission of the Marburg virus].

Experiments in guinea pigs and M. rhesus monkeys showed the possibility of contact infection of animals with Marburg virus. Secondary infection occurred most intensively when the monkeys were kept together but was also shown to be possible when the animals were separated but placed in the direction of the air flow from the sick monkeys as well as by "nose-to-nose" contact excluding the alimentary mode of transmission and the role of the agent excreted in the urine.

[Experimental Lassa fever in hamadryas baboons].

Intramuscular or aerogenic inoculation of baboons with Lassa virus reproduced a severe form of the disease which clinically, pathoanatomically and virologically resembles the severe form of human Lassa fever reported in the literature. The severity of monkey infection is demonstrated by rapid development of symptoms of general toxicity in the presence of fever, manifestations of hemorrhagic diathesis, high level of viremia and isolation of the causative agent from nasopharyngeal washings.

[The therapeutic efficacy of ribamidil and virazole in experimental Lassa fever in monkeys].

The therapeutic efficacy of ribamydil and virasol was evaluated in experimental Lassa fever in monkeys which received these drugs at various intervals after the onset of the clinical illness. Ribamydil or virasol administered in the first day of fever protected from death 60% to 66% of the infected animals, but when the drugs were given 2 days after the onset of fever the number of survivors declined to 0.20%.