CNN-LSTM vs. LSTM-CNN to Predict Power Flow Direction: A Case Study of the High-Voltage Subnet of Northeast Germany.

The massive installation of renewable energy sources together with energy storage in the power grid can lead to fluctuating energy consumption when there is a bi-directional power flow due to the surplus of electricity generation. To ensure the security and reliability of the power grid, high-quality bi-directional power flow prediction is required. However, predicting bi-directional power flow remains a challenge due to the ever-changing characteristics of power flow and the influence of weather on renewable power generation.

Radical surgical treatment of neuroendocrine tumors of the appendix in children - a Polish multicenter study.

Introduction: The aim of the study was to examine management of pediatric appendiceal neuroendocrine tumors (ANETs) in Poland.

Methods: Records of 27 patients with ANET diagnosed incidentally after appendectomy in the last decade.

Results: Well-differentiated NET G1/G2 was diagnosed in 25 and well-differentiated neuroendocrine carcinoma G3 in 2 patients.

Intramyocardial plasmid-encoding human vascular endothelial growth factor A165/basic fibroblast growth factor therapy using percutaneous transcatheter approach in patients with refractory coronary artery disease (VIF-CAD).

Background: VIF-CAD randomized, placebo-controlled, double-blind trial was an attempt to induce therapeutic angiogenesis by percutaneous intramyocardial transfer of bicistronic (vascular endothelial growth factor/fibroblast growth factor [VEGF/FGF]) plasmid (pVIF) in patients with refractory heart ischemia. Myocardial perfusion, clinical symptoms, exercise tolerance, left ventricular function, and safety were assessed.

Methods: Fifty-two patients with refractory coronary artery disease were randomized to receive VEGF/FGF plasmid (n = 33) or placebo plasmid (n = 19) into myocardial region showing stress-induced perfusion defects.

[Analysis of treatment results of boys referred to outpatient paediatric surgery centre with recognition of phimosis].

Unlabelled: The problem with prepuce retraction is caused not only by its narrowing, called phimosis, but also frequently by the inner prepuce adhesion to glans. The spontaneous prepuce retraction is received in 80% cases of boys up to the age of two, whereas in remaining cases, after the age of two it is necessary to take up the medical treatment. The purpose of the research was to estimate the effectiveness of conservative therapy using steroid ointments which was undertaken in boys referred to Outpatient Paediatric Surgery Centre with recognition of phimosis.

[Adeno-associated viruses (AAV)].

Recombinant adeno-associated virus derived vectors (rAAV) a thought to be a most promising candidates for gene therapy applications. Their nonpathogenic nature as well as the encouraging capability to infect both proliferating and non proliferating cells are advantages for gene therapy applications. Here, we summarize the potential mechanisms responsible for AAV maintenance and site-specific integration to human genome.

Variant t(2;11)(p11.2;q13) without IGK involvement in a case of mantle cell lymphoma.

Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation, which leads to overexpression of the cyclin D1 (CCND1) gene. This translocation is observed in almost all cases of MCL. In this alteration, the involvement of immunoglobulin heavy chain (IGH) locus plays a key role in the activation of the CCND1 oncogene.

Unusual cyclin D1 positive marginal zone lymphoma of mediastinum.

We report a case of 43-yr-old Caucasian female with an unusual, cyclin D1 positive marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) type of the mediastinum. To date, only about 30 cases of this entity have been published. They occur mainly in Asian females with a history of coexisting autoimmune disease.

Vascular endothelial growth factor and soluble FLT-1 receptor interactions and biological implications.

Vascular endothelial growth factor (VEGF), binding to an appropriate receptor like FLT, is the main mitogen for endothelial cells and a strong inducer of angiogenesis. A soluble form of VEGF receptor, sFLT-1, specifically binds VEGF and inhibits its activity. The following expression plasmids were used in the experiments: pVEGF plasmid encoding VEGF165, pFGF-2 encoding FGF-2 and psFLT-1 plasmid encoding the soluble form of VEGF receptor, sFLT-1.

"Bystander effect" induced by photodynamically or heat-injured ovarian carcinoma cells (OVP10) in vitro.

Background: The propagation of injury ("bystander effect") from directly damaged cells to other cells has been observed in cancer therapies. Some experiments suggested that this phenomenon was also detected in photodynamic therapy (PDT). The present study was undertaken to evaluate the bystander response in cells co-cultured with PDT- or heat-injured cells.

Mantle cell lymphoma presenting with paraproteinemia.

Mantle cell lymphoma (MCL) is most frequently diagnosed by the routine histological (HP) and immunohistochemical (IH) examination. Herein we present a case of 47-yr-old female with general lymphadenopathy and leukemic blood picture. She was initially diagnosed with marginal zone lymphoma (MZL).

In vivo study of angiogenic plasmid preparations--the bicistronic plasmid as a new type of drug for vascular diseases.

Angiogenic gene therapy is thought to be a new method for the treatment for vascular diseases. Plasmid preparations encoding angiogenic factors like a vascular endothelial growth factor (VEGF) or a fibroblast growth factor (FGF) effectively stimulate the formation of new vessels. The first clinical trials with novel angiogenic drugs--genetic preparations have already been reported.

Gene therapy of coronary artery disease with phvegf165--early outcome.

Background: Gene therapy is a new, experimental method of treatment in patients with coronary artery disease (CAD).

Aim: To determine the safety and efficacy of gene encoding vascular endothelial growth factor (VEGF165) administered directly into the myocardium as the single treatment or combined with coronary artery by-pass grafting (CABG).

Methods: VEGF gene transfer was performed in 22 patients (20 male, 2 female, ages from 48 to 73 years old).

Role of v-Raf and truncated form RAF1 in the induction of vascular endothelial growth factor and vascularization.

In this work we studied the effect of v-raf and different form RAF on up regulation of VEGF gene expression and angiogenesis. In the experiments the truncated forms of RAF1 gene were transfected into the cells of the established human urothelial line HCV-29, otherwise non-angiogenic. The plasmids coding for mitochondrial targeted dominant active or dominant negative RAF1 (DAM, DNM respectively) were deleted with RAS binding domain.

Cytostatic and cytotoxic effects of alkylglycerols (Ecomer).

Background: Shark liver oil, with a standardized concentration of alkylglycerols and their methoxyderivates, has been widely used in Scandinavian countries as complementary medicine in the treatment of different forms of cancer. The aim of our study was to verify the hypothesized antiproliferative effect of alkylglycerols in different human cancer cell lines.

Material/methods: The plating efficiency method was used to assay the effect of alkylglycerols on the plating efficiency of human ovarian carcinoma (OVP-10), mammary carcinoma (MCF-7), and prostate cancer (DU-145, PC-3 and PCa-2b) cell lines.

Construction of a bicistronic proangiogenic expression vector and its application in experimental angiogenesis in vivo.

Manipulation of angiogenesis in vivo is an example of successful gene therapy strategies. Overexpression of angiogenic genes like VEGF, FGF or PDGF causes new vessel formation and improves the clinical state of patients. Gene therapy is a very promising procedure but requires large amounts of pharmaceutical-grade plasmid DNA.

The role of focal adhesion kinase in the emigration of cells from confluent cultures.

We studied the effect of the modification of focal adhesion kinase (FAK) on the growth, migration and adhesion of C3H 10T1/2 cells. Cells transfected with plasmid coding for antisense FAK displayed a low level of FAK protein. Interestingly, the transfected cells achieved a higher saturation density at confluence, and displayed reduced adhesion and enhanced emigration from a confluent layer of cells when stimulated with fibronectin.