[Nummular headache is a rare type of primary headache in children and adults].

Nummular headache is a rather rare type, related to primary headaches according to the International Classification of Headache Disorders - III. Many aspects of nummular headache have not been studied, medical practitioners are unfamiliar with the clinical features and approaches to therapy. Statistics of this type of cephalgia in children is unknown.

[Methodical complex for the assessment of mass noninfectious prevalence rate and the medico-ecological situation in the territory].

The purpose of this article - the narration of main provisions of the algorithm of the system use of techniques and methods for the determination of the epidemiological risk for the morbidity of the population for the identification and assessment of mass noninfectious diseases, local variants ofpopulation health and the degree of stringency of medical and environmental conditions (or ecological trouble), in areas of industrial and non-administrative units of the area (region). Control-flow chartfor the evaluation of mass non-communicable diseases and medical-ecological situation in the territory on the basis of techniques and methods of risk assessment for decision-making control includes the following steps: 1) determination of the conditional regional level of the background prevalence rate as the unit of regional type of population health, shaped by regional climatic and geographic and other features of the environmental conditions; 2) detection of the epidemiological relative risk of the morbidity rate and mass non-infectious diseases; 3) determination of the wave-like character of the dynamics of the riskfor mass non-infectious morbidity rate of the population and the adaptation process shaping it in the territories; 4) separating the leading mass non-communicable diseases, especially shaping peculiarities of local variants of population health in the special industrial and non-industrial areas; 5) determination of the degree of stringency of medical and environmental situation (or ecological trouble) in the studied area, with local variants ofpopulation health; 6) a forecast of the expected trends in the dynamics of the risk for mass non-infectious prevalence rate; 7) justification of the main directions of the development of medical and environmental preventive measures on the reduction of mass non-infectious diseases and the improvement of the quality of health of the population in the studied areas. The given methodical complex will allow to more effectively solve problems ofprevention of mass non-infectious prevalence of the population and improve health and environmental conditions in the study area based on public health monitoring data.

[Features of local variants of population health in the territory of Irkutsk region according to indices of risk for morbidity].

Regional features of population health are formed under the influence of natural and anthropogenic loads. The improvement of the quality of life of the population depends on the effectiveness of performed preventative measures that are carried out with taking into account the features of the territories. Proposed approach for the detection of the local variants of population health with the aid of the method of estimation of the relative risk of morbidity allows to determine the features of population health (according to the number of leading ecodependent classes of diseases with enhanced and high risk for the incidence) in industrial and non-industrial areas and priorities among them, requiring preventive measures on the improvement of the level of population health and advancement of the quality of life of the population.

[Dynamics of adaptation processes and morbidity risk for the popupation of the territory of industrial cities].

There was investigated the character of the adaptation processes in the population residing in conditions ofprolonged exposure to environmental pollution in the territory of the industrial cities of the Irkutsk region in order to identify the possible periodicity of their manifestations in the formation of the morbidity risk for the population of different age groups. Under conditions of prolonged exposure to air pollution and other adverse unfavorable factors of industrial cities in the population of all age groups long cyclic changes of adaptation processes in the body in the form of repeated 11-15-years cycles in which a period of relative destabilization of physiological functions with lowered resistance is replaced by the period with the state of elevated nonspecific resistance were established to be observed. Undulating changes of the dynamics of the relative risks of general morbidity should be considered in the assessment of the medical and environmental situation in the territory and making the managing decisions at the base on the data of public health monitoring.

[The dynamics of the risk of morbidity in the industrial cities of Irkutsk region].

An assessment of the dynamics of medical and environmental situation in the industrialized cities of Irkutsk region on the relative risks of morbidity in children and adolescents due to changes in environmental loads in recent years (air pollution levels) was performed. The data presented indicate to environmental troubles in territories of considered industrial cities over the past two decades due to the high degree of intensity of medical and environmental situation on levels of morbidity (accordingly to medical aid appealability rate) of child and adolescent population.

[Problems of improving the assessment of health risk for assurance of the sanitary and epidemiological well-being].

There are considered the current problems of improving population health risk assessment for assurance of the sanitary and epidemiological well-being. Their solution permit to improve the risk assessment methodology in Russia and overcome unnecessary barriers in the way of a practical application of the criteria of acceptable risk and damage to health to support management decisions.

[Evaluation criteria of medical and ecological situation based on the method of sigma deviations].

Comparative analysis of the existing criteria for assessment of health and environmental situation was produced. The approach to health assessment of the environmental situation, where sigma intervals are used as criteria of belonging population morbidity in certain administrative areas in the region to the background incidence rate was proposed. The suggested criteria will increase the objectivity of the assessment of environmental health situation in the environment and health monitoring and implementation of epidemiological research.

Protein dynamics of a beta-sheet protein.

Rhodnius prolixus Nitrophorin 4 (abbreviated NP4) is an almost pure beta-sheet heme protein. Its dynamics is investigated by X-ray structure determination at eight different temperatures from 122 to 304 K and by means of Mössbauer spectroscopy. A comparison of this beta-sheet protein with the pure alpha-helical protein myoglobin (abbreviated Mbmet) is performed.

[Health status in children with diffuse thyroid enlargement under man-made pollution].

The paper presents data on lipid and protein metabolic parameters, hormonal profile, physical development, and the cardiovascular system in school children with and without diffuse thyroid enlargement from the industrial centers of the Irkutsk Region. The study has revealed changes in metabolic processes, physical development, and blood circulation in the population of children, which are considered to be manifestations of adaptive processes to environmental factors, primarily chemical ambient air pollution and iodine deficiency.

A water network within a protein: temperature-dependent water ligation in H64V-metmyoglobin and relaxation to deoxymyoglobin.

The sperm whale myoglobin mutant H64V, where the distal histidine is mutated to valine, is known to be five coordinated in the ferric state at room temperature and physiological pH. A change of the ligation in this H64V-Mbmet has been observed by optical absorption spectroscopy as a function of temperature from 20 K to 300 K. Above the dynamical transition at about 180 K one observes the temperature-dependent equilibrium between five- and six-ligated heme.

From metmyoglobin to deoxy myoglobin: relaxations of an intermediate state.

Metmyoglobin has been reduced at low temperature (below 100 K) using x-rays or by excitation of tris(2,2,bipyridine)ruthenium(II) chloride with visible light. Upon reduction, an intermediate state is formed where the structure of the protein is very similar to that of metmyoglobin with the water molecule still bound to the heme iron, but the iron is II low spin. The nature of the intermediate state has been investigated with optical spectroscopy.

Protein dynamics in an intermediate state of myoglobin: optical absorption, resonance Raman spectroscopy, and x-ray structure analysis.

A metastable state of myoglobin is produced by reduction of metmyoglobin at low temperatures. This is done either by irradiation with x-rays at 80 K or by electron transfer from photoexcited tris(2, 2'-bipyridine)-ruthenium(II) at 20 K. At temperatures above 150 K, the conformational transition toward the equilibrium deoxymyoglobin is observed.

[Quantitative evaluation of ecologically determined health risk among the population of industrial areas (on the example of the city of Angarsk)].

The authors discuss experience concerning use of risk evaluation methods. Those methods are designed to analyze and evaluate contribution made by air pollution sources into ecologically related risk for population living in territories of ecological hazard (exemplified by Angarsk city). Findings are that use of EPA methods combined with epidemiological risk evaluation technology appears the most effective.

[Polychromatic kinetics of conformational and spin relaxation of reduced intermediates of myoglobin].

Moessbauer spectroscopy was used to study the relaxation of a non-equilibrium myoglobin state produced at 77 K by reduction of metmyoglobin Fe(III) with thermalized electrons. The intermediate is characterized with the metMb (r) conformation of the protein globule and a low spin heme Fe(II) with a water molecule on the sixth coordination site. The intermediate is stable at 77 K but relaxes with increasing temperature into equilibrium deoxymyoglobin with dissociation of the bond Fe(II)-H2O and the transition of the Iron into the high spin state.

Mössbauer spectroscopy on nonequilibrium states of myoglobin: a study of r-t relaxation.

A frozen solution of 57Fe-enriched metmyoglobin was irradiated by x rays at 77 K. Mössbauer spectra showed a reduction of Fe(III) high spin by thermalized electrons and a production of a metastable Fe(II) low spin myoglobin complex with H2O at its sixth coordination site. The relaxation of the intermediate was investigated by Mössbauer spectroscopy as a function of temperature and time.

Mössbauer spectroscopy of oxygenated haemoglobins.

Murine tetrameric oxyhaemoglobin and insect monomeric erythrocruorin were studied. A doublet with the Lorentz form of lines (delta EQ = 2.22 mm s-1; delta alpha-Fe = 0.

[The use of an automated information system for monitoring atmospheric air pollution].

The paper presents the analysis of the development and pilot operation of hygienic monitoring of ambient air pollution on the basis of the automized informational system (AIS). Monitoring involves services of surveillance and control over sources of discharges and harmful impurities content in the atmosphere, meterological conditions, and AIS carrying out the functions of data collection and accumulation, analysis and assessment, prediction of the air basin status. The created instrument can be functioning in several regimens: for the analysis and assessment of the observed atmospheric status and the role of industrial sources in air pollution; for the prediction and assessment of the air basin status in association with the planned or expected effectiveness of measures aimed at the reduction of exhaust.