[THE HISTORY OF DEPARTMENT OF FACULTY THERAPY, AT THE VORONEZH HIGHER EDUCATION INSTITUTION (ON THE OCCASION OF THE CENTENARY ANNIVERSARY OF N.N. BURDENKO VORONEZH STATE MEDICAL UNIVERSITY)].

The article is devoted to the history of the Department of Faculty Therapy, N.N. Burdenko Voronezh State Medical University.

[Clinical manifestations of asthma during combination therapy using ceruloplasmin].

Aim: To estimate the time course of clinical changes in patients with asthma during combination therapy using ceruloplasmin (CP).

Materials And Methods: A total of 92 asthmatic patients were examined. Their medical history data were collected; external lung function testing and clinical, laboratory, and instrumental examinations, involving the determination of the indicators of lipid peroxidation (LPO) (malonic dialdehyde (MDA), methemoglobin, carboxyhemoglobin) and the antioxidant system (superoxide dismutase (COD), sulfhydryl groups), were performed in all the patients over time.

[CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ANEMIA: CLINICAL MANIFESTATIONS AND THERAPEUTIC STRATEGY].

Unlabelled: Anemia refers to manifestations of systemic inflammation in chronic obstructive pulmonary disease (COPD) and a factor aggravating the disease.

Objective: To study gender characteristics of anemia in patients with COPD, to increase the effectiveness of treatment through the use of pharmacological agents erythropoietin and enteral iron.

Materials And Methods: The paper presents clinical data on 74 patients with stage II/III COPD and anemia along with results of the treatment of 49 patients who received standard therapy in addition to epoetin and Sorbiferdurules.

[ANTIOXIDANT THERAPY OF BRONCHIAL ASTHMA].

This paper summarizes results of the investigations into the influence of antioxidants on the clinical picture of bronchial asthma. This disease is known to be accompanied by hyperactivation of lipid peroxidation. The use of antioxidants permits to correct free-radical oxidation (peroxidation) and enhances effectiveness of control over clinical symptoms.

[PROINFLAMMATORY CYTOKINES IN COMBINATION OF CORONARY HEART DISEASE AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE].

Chronic obstructive pulmonary disease and coronary heart disease frequently occur in combination. Systemic inflammation concomitant with protracted COPD is the pathogenetic mechanism of CHD. High concentration of the markers of systemic inflammation is associated with deterioration of atherosclerosis, its complications, and CHD progression.

[Comparison of data from registries of acute coronary syndromes RECORD and RECORD-2: management of patients and its results in noninvasive hospitals].

Positive changes are declared to occur during recent years in management of hospitalized patients with acute coronary syndromes (ACS) in Russia. Most of these changes are related to availability of invasive treatment. But considerable portion of patients (pts) are still treated in hospitals without facilities for invasive myocardial revascularization (noninvasive hospitals - NIHs).

[Adherence to guidelines on management of acute coronary syndrome in Russian hospitals and outcomes of hospitalization (data from the RECORD-2 Registry)].

Background: Complete following existing guidelines for management of acute coronary syndrome (ACS) is known to be associated with better outcomes. Partly this is explained by lesser adherence to recommendations in high risk patients. Aim of our study was to assess relationship between degree of following current guidelines and in hospital outcomes independently from initial assessment of risk.

[Electrocardiographic predictors of in-hospital outcomes of acute coronary syndrome].

Aim: To estimate the time course of changes in basic electrocardiographic (ECG) parameters in patients with acute coronary syndrome (ACS) as possible predictors of in-hospital outcomes.

Materials And Methods: The data of 277 patients with acute coronary syndrome (ACS) were used; QT-interval duration was studied by means of an EC12C-01 cardioanalyzer; ST-segment deviation (sigmaST), elevation (sigmaST-E), and depression (sigmaST-D) sums, and corrected QT-interval dispersion (DQTc) were calculated.

Results: There were highly significant differences of sigmaST in all the patients groups at admission and differences of DQTc in ACS patients with and without ST-segment elevation.

[Acquired androgen deficiency in men with chronic cardiac failure].

This review concerns the role of acquired androgen deficiency in pathogenesis of chronic cardiac failure (CCF) in men. It shows that patients with CCF and CHD suffer reduced testosterone production that correlates with impaired contractile activity of myocardium. It means that androgen deficiency due to combined bronchopulmonary and cardiovascular pathology promotes the early development of CCF.

[Anemia in patients with chronic cardiac failure].

The number of patients with chronic cardiac failure (CCF) grows continuously in the last decades especially among aged subjects compared with younger ones. Mortality and hospitalization rates among elderly subjects are also higher Hence, the importance of early diagnosis and treatment of concomitant diseases aggravating CCF, e.g.

[Ventricular extrasystole in patients with metabolic syndrome].

The aim of the study was to evaluate the prevalence and characteristics of ventricular extrasystole in patients developing metabolic syndrome. 24 hour echoCG monitoring was performed in 112 subjects above 15 yr meeting AHA/NHILBI 2005 criteria for metabolic syndrome corrected for the European population and in 107 metabolically neutral subjects. Significant differences were documented in the frequency of polytopic extrasystole (63.

[The role of erythrocytes in the system of controlled transport of pharmaceutical agents].

In the last decades, the possibility to use blood cells for delivery of pharmaceutical agents directly into a lesioned tissue has been given increasingly more attention. In the context of extracorporeal pharmacotherapy, the most promising approach is the use of autoerythrocytes possessed of unique morphological and physiological characteristics. Application of erythrocytes as containers for various drugs decreases the risk of side effects and pathologic immune reactions against encapsulated agents, permits to modify their pharmacokinetic and pharmacodynamic properties for reducing single and corse doses and intervals between them.

[Rhythm and conductivity disorders in patients at the initial stages of metabolic syndrome].

The aim of the work was to evaluate the prevalence of cardiac rhythm and conductance disturbances in patients with early manifestations of metabolic syndrome (MS). 24-hour ECG monitoring was undertaken in 105 patients meeting AHA/NHLBI (2005) MS criteria and in 79 healthy subjects. Exclusion criteria were the presence of diabetes mellitus, CHD, and obesity (body mass index > 40 kg/m2).

[Testosterone level in male patients with coronary heart disease and essential hypertension].

The study was undertaken to ascertain the prevalence of age-related androgen deficiency in patients with coronary heart disease (CHD) and essential hypertension under the age of 60 years and its association with some risk factors. The study covered 107 patients (mean age 50.2±7.

[Effect of ACE inhibitors on the mental status of elderly patients with chronic cardiac insufficiency].

This paper reviews prevalence of chronic cardiac insufficiency and effects of depression and anxiety conditions on its clinical course and prognosis. Clinical and experimental findings are discussed with reference to the role of the rennin-angiotensin-aldosterone system in pathogenesis of chronic cardiac insufficiency, depression, and certain psychic and nervous diseases. Special attention is given to the influence of CAE inhibitors on mental health of elderly subjects.

[Effects of metabolic syndrome on the phenomenon of electrophysiological atrioventricular conduction curve gap in the course of programmed transesophageal pacing].

Aim: To examine electrophysiological characteristics of the phenomenon of the atrioventricular curve gap (ACG) in patients with metabolic syndrome (MS).

Material And Methods: The study included patients aged over 15 years with ACG. Electrophysiological characteristics of this phenomenon were compared in 55 patients with MS (by NCEP ATP III 2001 criteria) and 47 free of MS.

[Effects of age-related androgen deficiency on clinical and psychological characteristics of patients with ischemic heart disease].

Aim: To study prevalence of androgen deficiency and its relations with clinicopsychological disorders in males with ischemic heart disease (IHD).

Material And Methods: A total of 87 males aged 31-60 years (58 with stable angina of effort FCII-III, 29 with progressive angina of effort) participated in the study. Clinical symptoms of androgen deficiency, severity of anxiety and depression, quality of life were characterized with scales AMS, HADS, D.

[Age-related androgen deficiency in men with ischemic heart disease].

The purpose of the research was to evaluate the age-related androgenic state in men with CHD and its relations with some risk factors. In this research 118 patients were included (average age 51.1 +/- 4.

[Acquired androgenic deficit and coronary heart disease].

This review is dedicated to the role of age-related acquired androgenic deficit in coronary heart disease (CHD) pathogenesis. The analysis of literature show that decrease of testosterone production in males leads to development of dyslipidemia, coronary atherosclerosis, obesity and to increase of blood trombus potential. Thus, androgen deficit potentiates early CHD development in males.

[The condition of pulmonary protective functions in patients with pneumonia accompanied by chronic viral hepatitis B].

Two groups of patients with pneumonia were observed: the main group consisted of patients with pneumonia accompanied by chronic viral hepatitis B (CVHB), and the control group contained patients without CVHB. Main group patients displayed higher activity of lysosomal and redox enzymes, as well as imbalance in the proteinase-inhibitory system and bronchial lavage phospholipid spectrum. Concomitant CVHB impaired the protective function of the lungs and thus delayed the resolution of pneumonia.

[Chronic heart failure in the elderly].

Chronic heart failure (CHF) presents the final stage of most cardiovascular diseases. The prevalence of CHF in patients with coronary artery disease grows steadily with age. CHF causes an abrupt fall in the quality of life and working ability.

[Some aspects of human mineral metabolic disturbances in viral hepatitis of various genesis].

A new prognostic criterion was developed to evaluate the severity of different forms of viral hepatitis, by studying zinc metabolism. In patients with viral hepatitis, zinc metabolic disturbances were ascertained to occur concurrently with pigment, protein, and carbohydrate metabolic disturbances, an increase in the activity of some serum enzymes (glutamine alkaline transferase, glutamine pyruvate transferase, alanine aminotransferase), and a reduction in hepatic antitoxic function. The indicator of normalization of zinc metabolism may be an additional prognostic criterion for evaluating the full recovery of a patient.

[Characterization of arrhythmia in pulmonary hypertension in patients with bronchial obstructive diseases].

To study the pattern and incidence of arrhythmias in relation to the mean pulmonary trunk pressure (MPTP), 24-hour SCG monitoring and Doppler pulse EchoCG were performed in 32 patients with chronic obstructive lung disease and in 13 patients with bronchial asthma. The summarized results of 24-hour ECG suggest that the number and grades of arrhythmias increase when MPTP becomes more than 13 mm Hg. There is a highly significant mean force correlation between MPTP and complicated cardiac arrhythmias (paroxysmal supraventricular tachycardia, coupled ventricular extrasystoles, and unsteady ventricular tachycardia).

[Clinical characteristics of hypertensive disease in patients with alexithymia].

Aim: To study hemodynamics and metabolism in patients with hypertensive disease and various severity of alexithymia.

Material And Methods: Psychological testing was included into complex examination of 202 patients with stage II hypertensive disease.

Results: Patients with alexithymia had longer duration of hypertensive load, higher frequency of target organs damage, intensified processes of lipid peroxidation and depressed activity of antioxidant defense, derangements of lipid metabolism.