Synthesis, Characterization, and Stability of {Mo}-Type Capsules Containing Phosphorus Oxo Anion Ligands.

This article deals with a set of {Mo}-type capsules containing phosphorus oxo anions as ligands. Two of them, with hypophosphite and phosphate ligands, respectively, were prepared and characterized by infrared (IR) spectroscopy and X-ray diffraction in Bielefeld more than two decades ago. We extended this pioneering work to phosphite and methylphosphonate ligands.

Photocatalytic Recovery of Noble Metals by Covalent Silyl Polyoxophosphotungstate-Porphyrin Copolymers.

The photocatalytic recovery of noble metals on photosensitive semiconductors such as TiO is well-established for forming M/TiO but has notable drawbacks. TiO suffers from low conversion efficiency due to significant recombination of photogenerated electron-hole pairs. Its wide energy band gap (3.

Multifunctional Supramolecular Gels with Strong Mechanical Properties Formed by Self-Assembly of Polyoxometalate-Based Coordination Polymers.

Metallogels built in a bottom-up approach by metal coordination and supramolecular interactions have important potential for the elaboration of smart materials. In this context, we present here the formation of supramolecular coordination polymers driven by the complexation of cobalt(II) or zinc(II) ions with polyoxometalate-based hybrids displaying two terpyridine ligands in a linear arrangement. Thanks to the electrostatic interactions between the polyoxometalate cores and metal nodes, the polymer chains self-assemble into fibers that physically cross-link to form gels above a critical concentration.

Single polyoxometalate-based nanoclusters characterized by infrared absorption nanospectroscopy.

Bottom-up engineering is a very attractive field. However, the periodic organization of molecules on a solid substrate is challenging, particularly in the selection of the appropriate characterization technique which is suitable for both large area and accurate analysis at the nanoscale. Here, this study demonstrates the unambiguous identification of complex molecular layers by infrared absorption microscopy at the nanometric scale.

Virus-Shaped Mesoporous Silica Nanostars to Improve the Transport of Drugs across the Blood-Brain Barrier.

Conditions affecting the brain are the second leading cause of death globally. One of the main challenges for drugs targeting brain diseases is passing the blood-brain barrier (BBB). Here, the effectiveness of mesoporous silica nanostars (MSiNSs) with two different spike lengths to cross an BBB multicellular model was evaluated and compared to spherical nanoparticles (MSiNP).

Neonatal sepsis due to NDM-1 and VIM-2 co-producing Pseudomonas aeruginosa in Morocco.

Background: Carbapenem-resistant Pseudomonas aeruginosa are being increasingly described worldwide. Here, we investigated the molecular mechanisms underlying carbapenem resistance in an extremely drug-resistant P. aeruginosa isolate from a neonatal intensive care unit in Morocco.

Halide-free CO cycloaddition onto styrene oxide catalysed by first row transition-metal derivatives of polyoxotungstates.

Quaternary ammonium salts of metal derivatives of polyoxometalates [XWOM(HO)] (X = P, Si; M = Cr, Mn, Co, Ni, Zn) were successfully tested instead of quaternary ammonium halides as catalysts in the cycloaddition of CO to styrene oxide. Remarkably, they gave very satisfactory yields of styrene carbonate at moderate temperature (80 °C).

Antibiotic Susceptibility Profiles of Bacterial Isolates Recovered from Abscesses in Cattle and Sheep at a Slaughterhouse in Algeria.

Abscesses represent the most prominent emerging problem in the red meat industry, leading to great economic constraints and public health hazards. Data on etiological agents present in these purulent lesions in Algeria are very scarce. The aim of this study was to identify the bacteria responsible for these abscesses and to determine their antibiotic susceptibility profiles.

KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas.

Importance: A paradoxical increase of growth hormone (GH) following oral glucose load has been described in ∼30% of patients with acromegaly and has been related to the ectopic expression of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in somatotropinomas. Recently, we identified germline pathogenic variants and somatic loss of heterozygosity of lysine demethylase 1A (KDM1A) in patients with GIP-dependent primary bilateral macronodular adrenal hyperplasia with Cushing's syndrome. The ectopic expression of GIPR in both adrenal and pituitary lesions suggests a common molecular mechanism.

Closed-Loop Insulin Delivery May Help Prevent Metabolic Complications During Bariatric Surgery in Patients with Type 1 Diabetes: A Case Report.

Obesity in patients with type 1 diabetes (T1D) may worsen their prognosis. Bariatric surgery in these patients can be associated with complications such as diabetic ketoacidosis and severe hypoglycemic episodes. Closed-loop insulin delivery could be a solution to avoid them.

Improvement in severe asthma patients receiving biologics and factors associated with persistent insufficient control: a real-life national study.

Background: Biological therapies have revolutionized the treatment of severe asthma with type 2 inflammation. Although such treatments are very effective in reducing exacerbation and the dose of oral steroids, little is known about the persistence of symptoms in severe asthma patients treated with biologics.

Purpose: We aim to describe asthma control and healthcare consumption of severe asthma patients treated with biologics.

Ready-to-be-addressed oxo-clusters: individualized, periodically organized and separated from the substrate.

Clusters and oxo-clusters are drawing attention for their amazing physical properties, especially at the scale of the single molecule. However, chemical methods to organize them individually on a surface are still lacking. In this study we show that it is possible to periodically organize individual polyoxometalates thanks to their ordering by a new supramolecular assembly.

Differential effects of SARS-CoV-2 variants on central nervous system cells and blood-brain barrier functions.

Background: Although mainly causing a respiratory syndrome, numerous neurological symptoms have been identified following of SARS-CoV-2 infection. However, how the virus affects the brain and how the mutations carried by the different variants modulate those neurological symptoms remain unclear.

Methods: We used primary human pericytes, foetal astrocytes, endothelial cells and a microglial cell line to investigate the effect of several SARS-CoV-2 variants of concern or interest on their functional activities.

Experimental observation of the role of countercations in modulating the electrical conductance of Preyssler-type polyoxometalate nanodevices.

Polyoxometalates are nanoscale molecular oxides with promising properties that are currently explored for molecule-based memory devices. In this work, we synthesize a series of Preyssler polyoxometalates (POMs), [Na⊂PWO], stabilized with four different counterions, H, K, NH, and tetrabutylammonium (TBA). We study the electron transport properties at the nanoscale (conductive atomic force microscopy, C-AFM) of molecular junctions formed by self-assembled monolayers (SAMs) of POMs electrostatically deposited on the ultraflat gold surface prefunctionalized with a positively charged SAM of amine-terminated alkylthiol chains.

Multi-Electron Visible Light Photoaccumulation on a Dipyridylamine Copper(II)-Polyoxometalate Conjugate Applied to Photocatalytic Generation of CF Radicals.

This article describes the synthesis and characterization of an organic-inorganic hybrid polyoxometalate functionalized by a short link with a tripodal N-based ligand and its copper complex. Upon visible light irradiation, the latter is able to store up to three reducing equivalents. The locus of the reduction is discussed based on physicochemical measurements and DFT calculations.

Food justice and land justice in São Paulo: urban subsistence farming on the margins of the city.

By relying on the case of São Paulo, this article seeks to develop a critical look at urban farming and its potential for contributing to food justice. While this activity constitutes a means of subsistence for urban communities, it is also underlain by principles relating to land ownership, which tend to divert attention from its primary role in food systems. There is an important need first to fight against land inequalities and bad housing in São Paulo, before considering urban farming as a lever for food justice.

Correction: Redox-controlled conductance of polyoxometalate molecular junctions.

Correction for 'Redox-controlled conductance of polyoxometalate molecular junctions' by Cécile Huez , , 2022, , 13790-13800, https://doi.org/10.1039/D2NR03457C.

-Related Channelopathy: Novel Pathogenic Variant and Review of the Literature.

Disease-associated pathogenic variants in the A-Kinase Anchor Protein 9 () (MIM *604001) have been recently identified in patients with autosomal dominant long QT syndrome 11 (MIM #611820), lethal arrhythmia (ventricular fibrillation, polymorphic ventricular tachycardia), Brugada syndrome, and sudden unexpected death. However, sequence variations were rarely reported and was classified as a "disputed evidence" gene to support disease causation due to the insufficient genetic evidence and a limited number of reported -mutated patients. Here, we describe a 47-year-old male carrying a novel frameshift pathogenic variant who presented recurrent syncopal attacks and sudden cardiac arrest that required a semi-automatic external defibrillator implant and an electric shock treatment of ventricular arrhythmia.

Redox-controlled conductance of polyoxometalate molecular junctions.

We demonstrate the reversible photoreduction of molecular junctions of a phosphomolybdate [PMoO] monolayer self-assembled on flat gold electrodes, connected by the tip of a conductive atomic force microscope. The conductance of the one electron reduced [PMoO] molecular junction is increased by ∼10, and this open-shell state is stable in the junction in air at room temperature. The analysis of a large current-voltage dataset by unsupervised machine learning and clustering algorithms reveals that the electron transport in the pristine phosphomolybdate junctions leads to symmetric current-voltage curves, controlled by the lowest unoccupied molecular orbital (LUMO) at 0.

Lennard-Jones interaction parameters of Mo and W in He and N from collision cross-sections of Lindqvist and Keggin polyoxometalate anions.

Drift tube ion mobility spectrometry (DTIMS) coupled with mass spectrometry was used to determine the collision cross-sections (CCS) of polyoxometalate anions in helium and nitrogen. As the geometry of the ion, more than its mass, determines the collision cross-section with a given drift gas molecule, we found that both Lindqvist ions MoO and WO had a CCS value of 103 ± 2 Å, and both Keggin ions PMoO and PWO had a CCS value of 170 ± 2 Å. Similarly, ion mobility experiments in N led to CCS values of 223 ± 2 Å and 339 ± 4 Å for Lindqvist and Keggin anions, respectively.

When Identification of the Reduction Sites in Mixed Molybdenum/Tungsten Keggin-Type Polyoxometalate Hybrids Turns Out Tricky.

The mixed molybdenum/tungsten Keggin-type polyoxometalate (POM) hybrid (TBA)[PWMoO{Sn(CHI)}] (TBA = -butylammonium) has been prepared by the reaction between [α-PWMoO] and [ClSn(CHI)] in dried acetonitrile, in the presence of tetra--butylammonium bromide. A further coupling reaction affords the ferrocenyl derivative (TBA)[PWMoO{Sn(CH)C≡C(CH)Fc}]. The POM hybrids have been thoroughly characterized by NMR and IR spectroscopies.