Fatal myocarditis secondary to Salmonella septicemia in a young adult.

A 29-year-old white male with a recent history of gastroenteritis sustained a cardiac arrest at home. He was found to be in ventricular fibrillation and could not be resuscitated. Pathologic findings included focal aggregates of histiocytes, lymphocytes and occasional neutrophils in the myocardium as well as inflammatory changes in the colon, liver, and spleen.

A reverse-phase liquid chromatographic assay for flavin-containing monooxygenase activity.

A rapid, convenient assay for flavin-containing monooxygenase activity is described. The method is based on direct analysis of quenched incubation mixtures by reverse-phase liquid chromatography, and utilizes p-nitrophenyl-1,3-oxathiolane as the substrate. The synthesis of the substrate and the product are described.

Stereoselective N-oxygenation of zimeldine and homozimeldine by the flavin-containing monooxygenase.

The metabolism of (Z)- and (E)-zimeldine and (Z)- and (E)-homozimeldine in hepatic rat and hog microsomes is described. The major metabolite observed in all cases examined was the tertiary amine N-oxide and it was formed at a rate 7-20 times that of norzimeldine or homonorzimeldine. N-Oxygenation requires NADPH and is stimulated by n-octylamine.

Minor and trace sterols from marine invertebrates 56. Novel coprostanols from the marine sponge Petrosia ficiformis.

Twelve stanols possessing the rare 5 beta-dihydro nucleus have been isolated from the marine sponge Petrosia ficiformis. These stanols have not previously been encountered in any samples of P. ficiformis which we have examined and appear to be the result of bacterial metabolism of the endogenous sponge sterols.

Minor and trace sterols in marine invertebrates 53 (1): Further novel marine sterols resulting from triple and quadruple biomethylation of the cholesterol side-chain.

The isolation and structure elucidation of nine new trace sterols with highly branched side chains from a Pseudaxinyssa species from the Australian Great Barrier Reef are described.

Medical reporting in the lay press.

Medical articles appearing in The Age during the first half of 1978 were reviewed. Thirty-three per cent were warnings or reports of adverse reactions, and 27% were reports of "new discoveries". A sample of these two groups of news items was evaluated by panels of doctors and laymen, and also assessed in the light of current literature.