[Rare forms of autosomal recessive spinocerebellar ataxia associated with mutations in the ANO10 (ATX-ANO10) and SYNE1 (ATX-SYNE1) genes].

Objective: To analyze clinical and genetic characteristics of patients with the verified rare forms of autosomal recessive spinocerebellar ataxias, ATX- and ATX-.

Material And Methods: Six unrelated patients with established diagnoses were examined: 4 patients with ATX- and 2 patients with ATX-. Brain MRI and nerve conduction study were performed.

[Physical rehabilitation for ankle joint injuries in the elderly and senile (stage 3).].

Ankle injuries are among the most common musculoskeletal injuries in the elderly. However, among the new scientific publications, both foreign and domestic, there are almost no examples and algorithms for conducting rehabilitation exercises for elderly patients, which prevents the introduction of these practices into rehabilitation measures. The purpose of our study is to evaluate the created technique of physical rehabilitation and, with a reliable result, to introduce it into the daily work of doctors of various profiles who provide assistance to patients with ankle joint injuries.

Coordination Compound (2,3,5-Triphenyltetrazolium)[CuBr] as Catalyst for the Curing Process of Epoxy Vinyl Ester Binders.

This article presents a study on the synthesis and catalytic properties of copper complex (TPhTz)[CuBr] (here TPhTz is 2,3,5-triphenyltetrazolium). The obtained complex was characterized by various spectroscopic methods. The catalytic properties of the complex were evaluated in the curing of an epoxy vinyl ester system and their effectiveness was compared with that of cobalt octoate (its synonyms are known as Co(Oct), cobalt(II) 2-ethylhexanoate, cobalt isocaprylate, etc.

Recycling of Epoxy/Fiberglass Composite Using Supercritical Ethanol with (2,3,5-Triphenyltetrazolium)[CuCl] Complex.

The widespread use of polymer composite materials (PCM) leads to an increase in non-recyclable waste. This paper discusses the feasibility of recycling fiberglass with an epoxy matrix by solvolysis in ethanol under supercritical conditions. The solvolysis process completes successfully within four hours in an environment of a pure solvent containing 10% water at a temperature of 280 °C when the solvent passes into the supercritical state.

[Physical rehabilitation for osteochondrosis of the cervical and thoracic spine in elderly and senile people (Stage 3).].

The concept of a multidisciplinary approach to the treatment of osteochondrosis in elderly and senile patients by specialists of various profiles using medicinal and non-medicinal methods is especially relevant today, therefore, it is necessary to develop and put into practice various options for the combined use of physical rehabilitation means at different stages of rehabilitation treatment of elderly and senile patients with osteochondrosis of the cervical and thoracic spine. The dynamics of clinical manifestations of osteochondrosis after rehabilitation treatment relative to the age of patients in groups showed that the effectiveness of the technique is much higher in elderly patients, in contrast to senile patients and centenarians. The study revealed no significant complications and side effects when using this technique, which allows us to recommend it as a means of secondary prevention of diseases of the cervical and thoracic osteochondrosis, especially in the presence of contraindications to the use of non-steroidal anti-inflammatory drugs and glucocorticoids.

Fault Identification in Electric Servo Actuators of Robot Manipulators Described by Nonstationary Nonlinear Dynamic Models Using Sliding Mode Observers.

The problem of fault identification in electric servo actuators of robot manipulators described by nonstationary nonlinear dynamic models under disturbances is considered. To solve the problem, sliding mode observers are used. The suggested approach is based on the reduced order model of the original system having different sensitivity to faults and disturbances.

[Gender-related differences in working practice and professional growth of dentists].

The paper presents some aspects of professional growth, continuous education and working conditions of female dentists having impact on treatment quality and dental service state in general. Questionnaire survey was carried out in 124 dentists, both male and female, aged 22 to 60 years. The study revealed gender asymmetry influencing their competitive ability, physical and emotional well-being.

[Differential approach to spring water choice regarding fluoride content for caries prevention].

The research includes an investigation of the tap water in different districts of Moscow. It was found out that Moscow tap water contains little fluoride, the difference between districts and okrugs is of no consequence. There is no centralized water fluoridization in Moscow therefore the authors suggest using bottled potable water with sufficient fluoride level.

Peculiarities of the Regulation of Gene Expression in the Ecl18kI Restriction-Modification System.

Transcription regulation in bacterial restriction-modification (R-M) systems is an important process, which provides coordinated expression levels of tandem enzymes, DNA methyltransferase (MTase) and restriction endonuclease (RE) protecting cells against penetration of alien DNA. The present study focuses on (cytosine-5)-DNA methyltransferase Ecl18kI (M.Ecl18kI), which is almost identical to DNA methyltransferase SsoII (M.

[Influence of high concentration of antibodies to NGF during early embryogenesis on formation of mice behavior in postnatal period].

In this work the influence of high concentration of antibodies to NGF on mouse's progeny has been investigated. During immunization with NGF the highest concentrations of antibodies were created in the first and third days of pregnancy (in different groups of animals). The dependence of abnormalities of mice postnatal development on level of antibodies to NGF at different stages of early embryogenesis has been established.

[The use of hydroxyapatite substance for the ostheosynthesis after comminuted thigh fractures].

The surgical tactics was analyzed in 102 patients operated on the comminuted thigh fractures. 95 patients were administered in a state of shock; 48 patients had multiple and combined injuries. All patients were operated on with the use of modern metal constructions.

Iron regulates expression of Bacillus cereus hemolysin II via global regulator Fur.

The capacity of pathogens to respond to environmental signals, such as iron concentration, is key to bacterial survival and establishment of a successful infection. Bacillus cereus is a widely distributed bacterium with distinct pathogenic properties. Hemolysin II (HlyII) is one of its pore-forming cytotoxins and has been shown to be involved in bacterial pathogenicity in a number of cell and animal models.

[The course of the diabetes type I in pregnants with different levels of antibodies to insulin].

The course of the diabetes type I at pregnants (n=120) with different levels of idiotypic (ABI) and antiidiotypic (AB2) antibodies to insulin was investigated. It is known that AB2 to insulin can interact with insulin receptor. It was shown that changes of levels AB1 and AB2 to insulin are often observed at pregnants suffered from diabetes type I.

[Surgical tactics in treatment of cervical spine injuries].

Surgical tactics were analyzed in 1350 patients with cervical spine injuries treated during 1972-2009 years. In 80% of cases injuries were caused by car accidents. 855 patients were admitted in acute or early period of trauma.

Laparoscopic repair of a posttraumatic left-sided diaphragmatic hernia complicated by strangulation and colon obstruction.

Background: Posttraumatic diaphragmatic hernias (PDH) are serious complications of blunt and penetrating abdominal or thoracic trauma. Traditional thoracic or abdominal operations are usually performed in these cases.

Methods: We present 2 cases of posttraumatic left-sided diaphragmatic hernia complicated by strangulation and colon obstruction.

Regulation of gene expression in restriction-modification system Eco29kI.

The Eco29kI restriction-modification (R-M) system consists of two partially overlapping genes, eco29kIR, encoding a restriction endonuclease and eco29kIM, encoding methyltransferase. The two genes are thought to form an operon with the eco29kIR gene preceding the eco29kIM gene. Such an organization is expected to complicate establishment of plasmids containing this R-M system in naive hosts, since common logic dictates that methyltransferase should be synthesized first to protect the DNA from cleavage by the endonuclease.

[Secondary structure of SsoII-like (cytosine-5)-DNA methyltransferases N-terminal region determined by circular dichroism spectroscopy].

(Cytosine-5)-DNA methyltransferase SsoII (M.SsoII) has a long N-terminal region (1-71 residues) preceding the sequence with conservative motifs, which are characteristic for all DNA methyltransferases of such kind. The presence of this region provides M.

[Perinatal outcomes in pregnant women with diabetes mellitus and different level of autoantibodies to insulin and its receptors].

The levels of idiotypic (AB1) and antiidiotypic (AB2) antibodies were investigated in pregnants (n = 248) suffer from diabetes. It was proved that AB2 to insulin conditionally can be regards as antibodies to insulin receptor. It was shown that condition of newborns much depends on levels of these antibodies and their proportion.

[Stomatological dispensary treatment of students of Moscow higher educational establishments and ways of its improvement].

As a result of clinical epidemiological survey of 432 Moscow students and of evaluation of medical records of annual dental examination, the high-level of various pathologies of dentitions and low efficiency of annual examination were found out in 232 students. It was traced back that main faults of dental examination of students were: poor coverage by medical examinations; occasional nature of examinations; incomplete revelation of pathologies; lack of remedial measures and educative activities.

[Factors influencing major stomatological diseases prevalence in student youth of Moscow city].

A clinical stomatological and social research of 432 young people at the age of 16-25 years was wade in establishments for higher and specialized secondary education in Moscow. It was found out that unbalanced food dominated by soft carbohydrates, frequent eating of sweets as well as low medical culture, lack of sanitary and hygienic knowledge and skills, negligence of preventive control contribute greatly to progression of caries and paradontal diseases. Bad habits and unheavy somatic affections do not have time early in life to exhibit their bad influence on teeth but they can violate the paradont.

[Prevalence of dental diseases among Moscow students and need of dentistry].

A clinical epidemiologic study was made among 432 Moscow students and as a part of it was found the high prevalence rate of pathologies of dentition and variety of nosologic forms. The most common cases were: caries, periodontal disease, deformity and anomalies of tooth position. These findings were necessary to estimate the need of all types of dentistry for Moscow students.

[Laparoscopic restoration of the colon continuity after Hartmann procedure].

Literature data and personal experience with laparoscopic restoration of the continuity of the colon after Hartmann's procedure in 19 patients allowed the authors to conclude that minimally traumatic procedures had a number of advantages over operations of wide laparotomy such as less blood loss, rapid restoration of the intestinal motility, early activation of the patients, shorter postoperative stay at hospital. They are also thought to be effective methods of treatment and prophylactics of peritoneal commissures and their complications.

Transcription regulation of restriction-modification system Ecl18kI.

Restriction-modification (R-M) system Ecl18kI is representative of R-M systems whose coordinated transcription is achieved through a separate DNA-binding domain of the methyltransferase. M.Ecl18kI recognizes an operator sequence located in the noncoding region that separates the divergently transcribed R and M genes.

SsoII-like DNA-methyltransferase Ecl18kI: interaction between regulatory and methylating functions.

The interaction of DNA-methyltransferase Ecl18kI (M.Ecl18kI) with a fragment of promoter region of restriction-modification system SsoII was studied. It is shown that dissociation constants of M.