Head to Head Comparison of Suppression of Tumorogenicity 2 and Copeptin Significance for Prognosis of Patients After Acute Heart Failure Decompensation.

Purpose: To assess the suppression of tumorogenicity 2 (ST2) and copeptin significance for risk stratification of patient (pts) with acute decompensated heart failure (ADHF) during long-term follow-up compared with traditional risk factors.

Methods: We included in a prospective study 159 pts with ADHF. Blood samples to determine copeptin, sST2, NT-proBNP and hsTnT concentration were collected at admission and at discharge from the hospital.

[Not Available].

Purpose: to study prognostic value of various biomarkers and their combinations in patients who survived decompensation of chronic heart failure.

Materials And Methods: Patients (n=159) who were hospitalized with diagnosis of heart failure (HF) decompensation were included in a prospective single-center study. Examination on admission and the day of hospital discharge, included measurement of concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hsTnT), copeptin, soluble suppression of tumorigenicity 2 (sST2), kopetin, neutrophil gelatinase-associated lipocalin (NGAL), and galectin-3.

[Not Available].

Aim: Monitoring of concentrations of modern biomarkers to evaluate the efficacy of long‑term treatment of patients after acute decompensated HF (ADHF).

Materials And Methods: The study included 100 patients with severe decompensated FC II-IV CHF and LV EF <40 % due to IHD, DCMP or AH. At discharge from the hospital, patients were divided into groups of low (NT‑proBNP<1400 pg / ml) (control, n=30) and high (NT‑proBNP≥1400 pg / ml) risk (n=70).

[Head to Head Comparison of Suppression of Tumorogenicity 2 and Copeptin Significance for Prognosis of Patients After Acute Heart Failure Decompensation].

Purpose: To assess the suppression of tumorogenicity 2 (ST2) and copeptin significance for risk stratification of patient (pts) with acute decompensated heart failure (ADHF) during long-term follow-up compared with traditional risk factors.

Methods: We included in a prospective study 159 pts with ADHF. Blood samples to determine copeptin, sST2, NT-proBNP and hsTnT concentration were collected at admission and at discharge from the hospital.

Regularity of non-stationary subdivision: a matrix approach.

In this paper, we study scalar multivariate non-stationary subdivision schemes with integer dilation matrix  and present a unifying, general approach for checking their convergence and for determining their Hölder regularity (latter in the case [Formula: see text]). The combination of the concepts of asymptotic similarity and approximate sum rules allows us to link stationary and non-stationary settings and to employ recent advances in methods for exact computation of the joint spectral radius. As an application, we prove a recent conjecture by Dyn et al.

[Therapy of High Risk Patients After Decompensation of Heart Failure Under NT-proBNP Control. Main Results].

Aim: to compare efficacy of treatment of high risk patients after acute decompensation (AD) of chronic heart failure (CHF) based on monitoring of NT-proBNP concentration and standard treatment.

Material And Methods: Patients (n=100) with class III-IV CHF and left ventricular ejection fraction (LV EF) <40% due to ischemic heart disease (IHD), dilated cardiomyopathy (DCMP), or arterial hypertension (AH) after compensation of HF before discharge were distributed into groups of low (NT-proBNP <1400 picog/ml, n=30) or high (NT-proBNP more or equal 1400 picog/ml, n=70) risk. High risk patients were randomized into 2 treatment groups: NT-proBNP based (group I, n=35) and standard (group II, n=35) therapy.

[Soluble Suppression of Tumorogenicity 2 Increases Opportunities for Risk Stratification After Acute Heart Failure Decompensation].

Purpose: to evaluate the significance of soluble ST2-receptor (sST2) concentrations in patient (pts) risk stratification in with acute decompensated heart failure (ADHF) during long-term follow-up period.

Methods: In the prospective single-center study were included 159 pts with ADHF III-IV FC NYHA. Blood samples to determine NT-proBNP, sST2, hsTnT concentration were collected at the admission and at discharge from the hospital, and after 3, 6 and 12 months of follow-up.

[The role of markers of organ damage in patients with chronic heart failure].

This review is devoted to the studies of the role of modern markers of myocardial and renal damage (high sensitivity troponin T [hsTnT] and urinary neutrophil gelatinase-associated lipocain [NGA/lipocalin-2] in patients with chronic heart failure (CHF). It contains description of nature, mechanism of synthesis, and release of hsTnT and NGAL, problems of variability of determination of these biomarkers, consideration of causes of elevation of their activity in CHF. Both hsTnT and NGAL have high diagnostic and prognostic significance.

[The Role of Markers of Organ Damage in Patients With Chronic Heart Failure].

This review is devoted to the studies of the role of modern markers of myocardial and renal damage (high sensitivity troponin T [hsTnT] and urinary neutrophil gelatinase-associated lipocain [NGAL/lipocalin-2] in patients with chronic heart failure (CHF). It contains description.

[Treatment of patients with chronic heart failure based on monitoring of concentrations of natriuretic peptides--to what extent it is justified in clinical practice?].

The review is devoted to consideration of novel pathways of treatment of patients with chronic heart failure (CHF) in particular of the high risk group. All main studies of the problem of treatment of patients with CHF based on monitoring of concentration of natriuretic peptides (MCNUP) BNP or NT-proBNP have been analyzed. The use of MCNUP with the aim of optimizing treatment of patients with CHF is completely justified biologically.

[A novel laboratory method of isolation and purification of tobramycin].

A new laboratory method for isolation and purification of tobramycin by using extraction of a tobramycin derivative with benzaldehyde by methylene chloride, subsequent hydrolysis of azomethine and recrystallization of the formed tobramycin sulfate from solution of sulfuric acid in methanol was developed. The method allows to exclude the stage of chromatographic purification of tobramycin, to reduce the time of the process realization from 120-125 h to 15-20 h, to increase the yield of the target product from 37-40% to 60-65% without decreasing the product quality, to exclude a number of large-size and expensive equipment and to ensure high reproducibility of the technology.

[Genetic markers of occupational susceptibility to fluorosis].

To determine markers showing propensity to occupational fluorosis, the authors studied prevalence of ABO, Rh, MN, ABH and Lewis phenotypes, systemic rhesus haplotypes in 229 workers engaged into aluminum production. Propensity to occupational fluorosis was marked by P (+), O (ABO) phenotypes. P (-) phenotype appeared to be a marker of resistance to fluorides exposure.

[Features of the intima of veins of the human vertebral canal].

The veins of the human vertebral canal have a complex internal structure that is stipulated with presence of a large amount of variable in form, size and position formations--plates, trabecules, complex and combined forms, parietal reticularity, cristae and valves. The data on peculiarities of macro-microconstruction of these structures, amount and their localization in various veins and parts of the vertebral canal are presented. Having analysed the data obtained, it is possible to divide the vertebral canal veins into three morphofunctional segments--superior (for the space of C1-C6), middle (C7-Th5) and inferior (Th6 and lower), possessing various hemodynamic characteristics Department of Human Anatomy, Medical Institute, Blagoveshchensk.

[Morphological characteristics of the human iliac veins].

Intravascular formations of the iliac veins, their anastomoses with the spinal veins have been studied in 255 preparations obtained from fetuses, children and mature persons of both sex. The methods applied are: macro- and microscopic preparation, injections, histological hematoxylin--eosin staining after van Gieson, Weigert and Mallory. It has been stated that morphological apparatus regulating blood stream in the pelvic veins are the intravascular formations, on the one hand, and anastomoses of these veins with the spinal veins, on the other hand.