[Fishes from the Volga-Caspian basin - vectors of pathogens of anthropozoonoses].

In the Volga-Caspian region there is abundant variety of parasitic species from different systematic groups. Some species ofparasites can be pathogenic not only for fish, but also for human that is why studies on the infection rate of commercial fish species by agents of are very topical for today. The work presents materials on invasiveness by the sanitary-significant helminthes of sheat fish, pike-perch, perch, pike, bream, Caspian roach, red-eye, sabrefish, silver bream, anchovy and ordinary kilka, herring, Caspian shad, black-backed shad.

[Heterogeneity of Bacillus anthracis strains in terms of their adhesive capacity].

The homogeneity of colonies of two B. anthracis vaccine strains in R- and RS- forms (100 colonies of each strain) in terms of their adhesive capacity was studied. B.

[The effect of the in-vitro interaction of antibacterial preparations on Brucella melitensis].

The character of drug interaction in 18 various combinations of sisomicin, amikacin, gentamicin, cefotaxime, doxycycline, trimethoprim and nitroxaline was studied by the chess board method with respect to 25 strains of Brucella melitensis. The synergistic effect with respect to the majority of the cultures was observed with the use of the combinations of gentamicin, amikacin or sisomicin with doxycycline. The combinations of the aminoglycosides with cefotaxime and sisomicin or gentamicin with rifampicin had a summation effect on the majority of the cultures.

[Sensitivity of Brucella melitensis to various antibiotics, drug preparations and their combinations].

In vitro activity of 13 antibiotics and drug preparations as well as some of their combinations was studied with respect to Brucella melitensis. It was shown that the strains of B. melitensis were sensitive to sisomicin, amikacin, gentamicin, cefotaxime, rifaprim +, nitroxoline and trimethoprim.

[The prostaglandin and cyclic nucleotide levels in the organs of mice with experimental anthrax intoxication].

In this work the influence of Bacillus anthracis toxin, introduced intraperitoneally in a dose of LD100, on the content of prostaglandins E and F2 alpha, 6-ketoprostaglandin F1 alpha, thromboxane, cAMP and cGMP in the lungs, heart, liver and spleen of BALB/c mice in the time course of experimental intoxication has been studied. The concentration and proportion of prostaglandins and cyclic nucleotides have been shown to undergo-sharp changes in all organs under study in the process of intoxication. The level and proportion of prostaglandins in the lungs ensures the development of vaso- and bronchodilatation processes even at early stages of the action of the toxin.

[Methodological characteristics of the use of the immunofluorescence method for the rapid determination of the sensitivity of the anthrax microbe to antibiotics].

An immunofluorescent method for rapid assay of antibiotic sensitivity of Bacillus anthracis was tested with the use of virulent strains. It was shown that the immunofluorescent method was applicable for assay of antibiotic sensitivity of Bacillus anthracis immediately upon inoculation of the native matter: soil samples and other materials. Comparison of the results obtained with the method of serial dilutions and the immunofluorescent method showed that the levels of the Bacillus anthracis sensitivity to rifampicin, benzylpenicillin, tetracycline, streptomycin and gentamicin coincided.

[Comparative evaluation of methods for determining the sensitivity of the anthrax microbe to antibiotics].

Comparison of the results of determination of antibiotic sensitivity of the cultures of the anthrax causative agent with the methods of serial dilutions and paper disks revealed coincidence of their antibiotic sensitivity levels. The Unimicon-s and AGV media can be used for determination of antibiotic sensitivity of the anthrax causative agent by the above methods.

[Antibiotic sensitivity of strains of the plague microbe isolated from foci in the Caucasus and Transcaucasia].

Antibiotic sensitivity of 91 strains of the plague microbe isolated in Armenia, Azerbaijan, Daghestan, Georgia, Kabardino-Balkaria and the Stavropol region in 1977-1979 from the rodents and their ectoparasites was studied with the method of serial dilutions in the Hottinger agar. The following antibiotics were tested: streptomycin, erythromycin, tetracycline, methicillin, gentamicin, levomycetin, monomycin, lincomycin, ristomycin, rifampicin, kanamycin, doxycyclin and polymyxin M. All of the strains irrespective of their nature were resistant to methicillin, erythromycin, lincomycin, ristomycin and polymyxin M.