Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients.

The clinical course of 40 patients with significant quantities of mixed cryoglobulins, but without lymphoproliferative, collagen-vascular or chronic infectious diseases, is presented. These cases comprise 51.3 percent of all mixed and 31.

Morphogenesis of rabbit fibroma virus. Correlation with pathogenesis of the skin lesion.

Rabbit fibroma virus injected into the dermis of adult rabbit skin evokes an inflammatory, then granulomatous and finally proliferative or tumoral response. About 1 week after injection, the grossly visible nodular lesion reaches its maximum size and regresses, becoming hemorrhagic and necrotic. Unlike vacciiia, the morphogenesis of the RFV has not been validated satisfactorily.

The uptake of a labeled double-stranded polynucleotide by cultured rabbit kidney cells: an electron microscopic study.

Polyribocytidylate-(3)H-polyriboinosinate (rC-(3)H:rI) enters cultured rabbit kidney cells from the surrounding medium within (1/2) hr after exposure. Grains are found in the cytoplasm, nucleus, and nucleolus. At 2 hr, grains are localized predominantly over the nucleolar regions.

Studies of a myxovirus recovered from patients with infectious hepatitis. II. Fine structure and electron microscopic demonstration of intracytoplasmic internal component and viral filament formation.

WB virus has been shown to have a fine structure which is characteristic of members of the mumps-NDV-parainfluenza group of viruses. Viral internal component has been demonstrated within the cytoplasm of infected cells. The incorporation of internal component into virus filaments at the cell surface has also been demonstrated.

The effects of antibodies on cells. 3. Studies on the interaction of rat liver mitochondria and lysosomes with antibody and complement.

Complement-fixing and precipitating antibodies to mitochondrial and lysosomal fractions of rat liver were induced in rabbits. The incubation of these subcellular fractions with ferritin-labelled antibody revealed localization of the antibody on mitochondria and lysosomes, but no specific morphological effect of antibody and complement. Incubation of the cell fractions with antibody and complement did not impair the efficiency of mitochondrial oxidative phosphorylation or affect the latency and sedimentation characteristics of lysosomal acid phosphatase.