Infants' Social Evaluation of Helpers and Hinderers: A Large-Scale, Multi-Lab, Coordinated Replication Study.

Evaluating whether someone's behavior is praiseworthy or blameworthy is a fundamental human trait. A seminal study by Hamlin and colleagues in 2007 suggested that the ability to form social evaluations based on third-party interactions emerges within the first year of life: infants preferred a character who helped, over hindered, another who tried but failed to climb a hill. This sparked a new line of inquiry into the origins of social evaluations; however, replication attempts have yielded mixed results.

Adults and Children Engage in Subtle and Fine-Grained Action Interpretation and Evaluation in Moral Dilemmas.

Understanding the actions of others is fundamental for human social life. It builds on a grasp of the subjective intentionality behind behavior: one action comprises different things simultaneously (e.g.

Genomic Instability and Epigenetic Changes during Aging.

Aging is considered the deterioration of physiological functions along with an increased mortality rate. This scientific review focuses on the central importance of genomic instability during the aging process, encompassing a range of cellular and molecular changes that occur with advancing age. In particular, this revision addresses the genetic and epigenetic alterations that contribute to genomic instability, such as telomere shortening, DNA damage accumulation, and decreased DNA repair capacity.

How robust are egocentric and altercentric interference effects in social cognition? a test with explicit and implicit versions of a continuous false belief task.

It has been long assumed that meta-representational theory of mind (ToM) -our ability to ascribe mental states to ourselves and other people- emerges around age four as indicated in performance on explicit verbal false belief tasks. In contrast, newer studies assessing false belief understanding with implicit, non-verbal measures suggest that some form of ToM may be present even in infancy. But these studies now face replication issues, and it remains unclear whether they can provide robust evidence for implicit ToM.

Drought stress triggers alterations of adaxial and abaxial stomatal development in basil leaves increasing water-use efficiency.

The physiological control of stomatal opening by which plants adjust for water availability has been extensively researched. However, the impact of water availability on stomatal development has not received as much attention, especially for amphistomatic plants. Therefore, the acclimation of stomatal development in basil ( L.

Fungal Drug Response and Antimicrobial Resistance.

Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals. The limited number of antifungal agents and the emergence of resistance have led to a critical need to understand the mechanisms of antifungal drug resistance.

Far-Red Light Mediated Carbohydrate Concentration Changes in Leaves of Sweet Basil, a Stachyose Translocating Plant.

Photosynthetic active radiation (PAR) refers to photons between 400 and 700 nm. These photons drive photosynthesis, providing carbohydrates for plant metabolism and development. Far-red radiation (FR, 701-750 nm) is excluded in this definition because no FR is absorbed by the plant photosynthetic pigments.

Severe acute respiratory syndrome coronavirus-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca homeostasis in yeast.

Virus infection involves the manipulation of key host cell functions by specialized virulence proteins. The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) small accessory proteins ORF3a and ORF7a have been implicated in favoring virus replication and spreading by inhibiting the autophagic flux within the host cell. Here, we apply yeast models to gain insights into the physiological functions of both SARS-CoV-2 small open reading frames (ORFs).

Divergence of alternative sugar preferences through modulation of the expression and activity of the Gal3 sensor in yeast.

Optimized nutrient utilization is crucial for the progression of microorganisms in competing communities. Here we investigate how different budding yeast species and ecological isolates have established divergent preferences for two alternative sugar substrates: Glucose, which is fermented preferentially by yeast, and galactose, which is alternatively used upon induction of the relevant GAL metabolic genes. We quantified the dose-dependent induction of the GAL1 gene encoding the central galactokinase enzyme and found that a very large diversification exists between different yeast ecotypes and species.

Five-year-old children value reasons in apologies for belief-based accidents.

Accidents can be intent-based (unintended action-unintended outcome) or belief-based (intended action-unintended outcome). As compared to intent-based accidents, giving reasons is more crucial for belief-based accidents because the transgressor appears to have intentionally transgressed. In Study 1, UK-based preschoolers who were native English speakers (N = 96, 53 girls, collected 2020-2021) witnessed two intent-based or belief-based accidents; one transgressor apologized, the other apologized with a reason.

Corrigendum: Knowledge before belief ascription? Yes and no (depending on the type of "knowledge" under consideration).

[This corrects the article DOI: 10.3389/fpsyg.2022.

Do young children track other's beliefs, or merely their perceptual access? An interactive, anticipatory measure of early theory of mind.

This paper aimed to contribute to answering three questions. First, how robust and reliable are early implicit measures of false belief (FB) understanding? Second, do these measures tap FB understanding rather than simpler processes such as tracking the protagonist's perceptual access? Third, do implicit FB tasks tap an earlier, more basic form of theory of mind (ToM) than standard verbal tasks? We conducted a conceptual replication of Garnham & Perner's task (Garnham and Perner 2001 , 413-432) simultaneously measuring children's anticipatory looking and interactive behaviours toward an agent with a true or FB ( = 81, = 40 months). Additionally, we implemented an ignorance condition and a standard FB task.

How do children overcome their pragmatic performance problems in the true belief task? The role of advanced pragmatics and higher-order theory of mind.

The true belief (TB) control condition of the classical location-change task asks children to ascribe a veridical belief to an agent to predict her action (analog to the false belief (FB) condition to test Theory of Mind (ToM) abilities). Studies that administered TB tasks to a broad age range of children yielded surprising findings of a U-shaped performance curve in this seemingly trivial task. Children before age four perform competently in the TB condition.

Chimpanzees consider freedom of choice in their evaluation of social action.

Judgements of wrongdoing in humans often hinge upon an assessment of whether a perpetrator acted out of free choice: whether they had more than one option. The classic inhibitors of free choice are constraint (e.g.

Online Testing Yields the Same Results as Lab Testing: A Validation Study With the False Belief Task.

Recently, online testing has become an increasingly important instrument in developmental research, in particular since the COVID-19 pandemic made in-lab testing impossible. However, online testing comes with two substantial challenges. First, it is unclear how valid results of online studies really are.

Chimpanzees consider alternative possibilities.

Humans reason not only about actual events (what is), but also about possible events (what could be). Many key operations of human cognition involve the representation of possibilities, including moral judgment, future planning, and causal understanding. But little is known about the evolutionary roots of this kind of thought.

Children understand subjective (undesirable) desires before they understand subjective (false) beliefs.

Our folk psychology is built around the ascription of beliefs (and related cognitive states) and desires (and related conative states). How and when children develop a concept of these different kinds of propositional attitudes has been the subject of a long-standing debate. Asymmetry accounts assume that children develop a conception of desires earlier than they develop a concept of beliefs.

Soil Moisture Levels Affect the Anatomy and Mechanical Properties of Basil Stems ( L.).

As plants would benefit from adjusting and optimizing their architecture to changing environmental stimuli, ensuring a strong and healthy plant, it was hypothesized that different soil moisture levels would affect xylem and collenchyma development in basil ( L. cv. Marian) stems.

Actions do not speak louder than words in an interactive false belief task.

Traditionally, it had been assumed that meta-representational Theory of Mind (ToM) emerges around the age of 4 when children come to master standard false belief (FB) tasks. More recent research with various implicit measures, though, has documented much earlier competence and thus challenged the traditional picture. In interactive FB tasks, for instance, infants have been shown to track an interlocutor's false or true belief when interpreting her ambiguous communicative acts (Southgate .

Capturing and Understanding the Dynamics and Heterogeneity of Gene Expression in the Living Cell.

The regulation of gene expression is a fundamental process enabling cells to respond to internal and external stimuli or to execute developmental programs. Changes in gene expression are highly dynamic and depend on many intrinsic and extrinsic factors. In this review, we highlight the dynamic nature of transient gene expression changes to better understand cell physiology and development in general.

The Impact of Hydro-Priming and Osmo-Priming on Seedling Characteristics, Plant Hormone Concentrations, Activity of Selected Hydrolytic Enzymes, and Cell Wall and Phytate Hydrolysis in Sprouted Wheat ( L.).

Priming improves the seed germination rate and grain yield. Before this work was executed, little, if any, research has been reported on priming wheat for improving its nutritional properties. The impact of hydro-priming and osmo-priming using solutions with different water potentials on selected hydrolytic enzyme activities and their breakdown of starch, cell wall materials, and phytates during subsequent sprouting was studied here.

Live-cell assays reveal selectivity and sensitivity of the multidrug response in budding yeast.

Pleiotropic drug resistance arises by the enhanced extrusion of bioactive molecules and is present in a wide range of organisms, ranging from fungi to human cells. A key feature of this adaptation is the sensitive detection of intracellular xenobiotics by transcriptional activators, activating expression of multiple drug exporters. Here, we investigated the selectivity and sensitivity of the budding yeast () multidrug response to better understand how differential drug recognition leads to specific activation of drug exporter genes and to drug resistance.

Dose dependent gene expression is dynamically modulated by the history, physiology and age of yeast cells.

Cells respond to external stimuli with transient gene expression changes in order to adapt to environmental alterations. However, the dose response profile of gene induction upon a given stress depends on many intrinsic and extrinsic factors. Here we show that the accurate quantification of dose dependent gene expression by live cell luciferase reporters reveals fundamental insights into stress signaling.

Children's understanding of the aspectuality of intentions.

When children come to grasp the concept of intention is a central question in theory of mind research. Existing studies, however, present a puzzling picture. On the one hand, infants distinguish between intentional and accidental actions.