RAFT polymerization mediated core-shell supramolecular assembly of PEGMA--stearic acid block co-polymer for efficient anticancer drug delivery.

In this work, core-shell supramolecular assembly polymeric nano-architectures containing hydrophilic and hydrophobic segments were synthesized reversible addition fragmentation chain transfer (RAFT) polymerization. Herein, polyethylene glycol methyl ether methacrylate (PEGMA), and stearic acid were used to synthesize the poly(PEGMA) homopolymer and stearyl ethyl methacrylate (SEMA), respectively. Then, PEGMA and SEMA were polymerized through controlled RAFT polymerization to obtain the final diblock copolymer, poly(PEGMA--SEMA) (BCP).

AgNPs Ornamented Modified Bacterial Cellulose Based Self-Healable L-B-L Assembly a Schiff Base Reaction: A Potential Wound Healing Patch.

A layer-by-layer (L-B-L) bacterial cellulose (BC)-based transdermal patch has been prepared a Schiff base reaction. The L-B-L assembly consisting of covalently cross-linked ethylene diamine-modified carboxymethylated BC isolated from the (MTCC7795) bacterial strain and aldehyde-modified pectin formed a Schiff base reaction. The presence of the imine bond assists the self-healing process after being scratched in the presence of a pH 7.

Folic acid based carbon dot functionalized stearic acid-g-polyethyleneimine amphiphilic nanomicelle: Targeted drug delivery and imaging for triple negative breast cancer.

Development of advanced therapeutic modalities for the treatment of cancer are become a thirst area in the field of biomedical science now a day. Current therapeutic approaches to treat this fatal disease always refer to partial curability with unavoidable obstacles. Here, we have developed stearic-g-polyethyleneimine acid amphiphilic nanomicelle functionalized with folic acid-based carbon dots (CDs) for targeted anticancer drug (doxorubicin, DOX) delivery and concurrent bio-imaging for triple negative breast cancer (TNBC).