Publications by authors named "Priyankana Banerjee"
Article Synopsis
- Knowledge of MHC class I ligands for KIRs in rhesus macaques is key to understanding natural killer cell functions in studies of infectious diseases and reproductive biology.
- Mamu-AG, which is similar to the human HLA-G, is a polymorphic nonclassical MHC class I molecule found at the maternal-fetal interface; different allotypes of KIR3DL05 have varying responses to Mamu-AG alleles.
- Research discovered specific amino acid residues in Mamu-AG that are critical for KIR recognition, demonstrating how genetic variations can influence immune responses in this nonhuman primate model.
Strong connections exist between R-loops (three-stranded structures harbouring an RNA:DNA hybrid and a displaced single-strand DNA), genome instability and human disease. Indeed, R-loops are favoured in relevant genomic regions as regulators of certain physiological processes through which homeostasis is typically maintained. For example, transcription termination pause sites regulated by R-loops can induce the synthesis of antisense transcripts that enable the formation of local, RNA interference (RNAi)-driven heterochromation.
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- The rhesus macaque is a significant model for studying AIDS and infectious diseases, but KIR function studies have been limited due to unknown ligands.
- Researchers developed stable cell lines to identify ligands for rhesus macaque KIRs by using luciferase reporter systems with target cells expressing MHC class I molecules.
- They discovered specific ligands for various KIRs, including Mamu-KIR3DL01, which recognizes Mamu-Bw4 molecules, and Mamu-KIR3DL05 that binds to multiple Mamu-A related molecules, highlighting their implications in reproductive biology and NK cell function.
Lymphatic filariasis (LF) is a tropical parasitic infection of human transmitted by mosquitoes. Chronic infection results in severe physical disability in the infected patients. Although several potential vaccine antigens were identified by several groups, there are no licensed prophylactic vaccine to date against this infection in the human.
View Article and Find Full Text PDFMass drug administration (MDA) is the current strategy for interrupting the transmission of lymphatic filariasis (LF) infection and control of the disease in endemic areas. However, subject non-compliance has resulted in the presence of several "transmission hotspots" in the endemic regions threatening the reemergence of LF. This situation is further complicated by the fact that the drugs used in MDA are not effective against adult LF worms, a major concern for the control strategy.
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