Analysis of Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism.

 Mandibular prognathism (MP) is a craniofacial deformity resulting from the combined effects of environmental and genetic factors. Although various linkage and genome-wide association studies for mandibular prognathism have identified multiple strongly associated regions and genes, the causal genes and variants responsible for the deformity remained ambiguous.  This research work was aimed to study the association between polymorphism rs10850110 of the gene and skeletal class-III malocclusion in our local population.