Model-based predictive greenhouse parameter control of aquaponic system.

The effectiveness of an aquaponic system significantly relies on the habitat provided for both the fish and plants. As an integral component of aquaponics, hydroponic cultivation benefits greatly from the controlled environment of a greenhouse. Within this environment, factors such as temperature, carbon dioxide levels, humidity, and light can be carefully adjusted to maximize plant growth and development.

A feature boosted deep learning method for automatic facial expression recognition.

Automatic facial expression recognition (FER) plays a crucial role in human-computer based applications such as psychiatric treatment, classroom assessment, surveillance systems, and many others. However, automatic FER is challenging in real-time environment. The traditional methods used handcrafted methods for FER but mostly failed to produce superior results in the wild environment.

Stress Responses Elicited by Misfolded Proteins Targeted to Mitochondria.

The double-membrane-bound architecture of mitochondria, essential for ATP production, sub-divides the organelle into inter-membrane space (IMS) and matrix. IMS and matrix possess contrasting oxido-reductive environments and discrete protein quality control (PQC) machineries resulting inherent differences in their protein folding environments. To understand the nature of stress response elicited by equivalent proteotoxic stress to these sub-mitochondrial compartments, we took misfolding and aggregation-prone stressor proteins and fused it to well described signal sequences to specifically target and impart stress to yeast mitochondrial IMS or matrix.

Statistical power and sample size requirements to detect an intervention by time interaction in four-level longitudinal cluster randomized trials.

Cluster/group randomized controlled trials (CRTs) have a long history in the study of health sciences. CRT is a special type of intervention trial in which a complete group is randomly assigned to a study condition (or intervention). It is typically performed when individual randomization is difficult/impossible without substantial risk of contamination across study arms or prohibitive from the cost or group dynamics point of view.

Possible Therapeutic Intervention Strategies for COVID-19 by Manipulating the Cellular Proteostasis Network.

Introduction: The recent outbreak of coronavirus infection by SARS-CoV-2 that started from the Wuhan Province of China in 2019 has spread to most parts of the world infecting millions of people. Although the case fatality rate of SARS-CoV-2 infection is less than the previous epidemics by other closely related coronaviruses, due to its high infectivity, the total number of SARS-CoV-2 infection-associated disease, called Covid-19, is a matter of global concern. Despite drastic preventive measures, the number of Covid-19 cases are steadily increasing, and the future course of this pandemic is highly unpredictable.

Application of improved fuzzy best worst analytic hierarchy process on renewable energy.

In this work, a novel fuzzy decision making technique namely trapezoidal fuzzy Best-Worst method (fuzzy BWM) is developed which is based on Best-Worst method (BWM) and Trapezoidal fuzzy number. The real motive behind our work is to take a broad view of the existing fuzzy BWM based on triangular fuzzy number by trapezoidal fuzzy number. Also, we have presented a new hybrid MCDM technique called as Trapezoidal fuzzy Best Worst Analytic Hierarchy based on proposed trapezoidal fuzzy BWM and existing trapezoidal fuzzy Analytic Hierarchy Process (AHP).

Alterations in inter-organelle crosstalk and Ca signaling through mitochondria during proteotoxic stresses.

Background: Biogenesis and function of mitochondria is profoundly dependent on cytosolic translation of mitochondrial pre-proteins and its subsequent translocation and folding inside the organelle. Continuous exposure of non-native precursor proteins, exposure to damaging by-products of oxidative phosphorylation, load of mis-targeted or misfolded proteins from neighbouring compartments and unremitting demand of communication between mitochondrial and nuclear genomes, continuously pose proteotoxic threats to the organelle. Our knowledge of cellular mechanisms to cope up with such impending threat of proteotoxicity to mitochondria, is currently evolving.

Cytosolic aggregates in presence of non-translocated proteins perturb endoplasmic reticulum structure and dynamics.

Presence of cytosolic protein aggregates and membrane damage are two common attributes of neurodegenerative diseases. These aggregates delay degradation of non-translocated protein precursors leading to their persistence and accumulation in the cytosol. Here, we find that cells with intracellular protein aggregates (of cytosolic prion protein or huntingtin) destabilize the endoplasmic reticulum (ER) morphology and dynamics when non-translocated protein load is high.

MGRN1-mediated ubiquitination of α-tubulin regulates microtubule dynamics and intracellular transport.

MGRN1-mediated ubiquitination of α-tubulin regulates microtubule stability and mitotic spindle positioning in mitotic cells. This study elucidates the effect of MGRN1-mediated ubiquitination of α-tubulin in interphase cells. Here, we show that MGRN1-mediated ubiquitination regulates dynamics of EB1-labeled plus ends of microtubules.

Lysosomal Quality Control in Prion Diseases.

Prion diseases are transmissible, familial or sporadic. The prion protein (PrP), a normal cell surface glycoprotein, is ubiquitously expressed throughout the body. While loss of function of PrP does not elicit apparent phenotypes, generation of misfolded forms of the protein or its aberrant metabolic isoforms has been implicated in a number of neurodegenerative disorders such as scrapie, kuru, Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Sträussler-Scheinker and bovine spongiform encephalopathy.

ESCRTs and associated proteins in lysosomal fusion with endosomes and autophagosomes.

Endolysosomal and autophagosomal degradation pathways are highly connected at various levels, sharing multiple molecular effectors that modulate them individually or simultaneously. These two lysosomal degradative pathways are primarily involved in the disposal of cargo internalized from the cell surface or long-lived proteins or aggregates and aged organelles present in the cytosol. Both of these pathways involve a number of carefully regulated vesicular fusion events that are dependent on ESCRT proteins.

WITHDRAWN: Lysosomal dysfunction in prion protein-mediated neurodegeneration.

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. doi of the article: 10.