Publications by authors named "Priyanka Keshri"
Article Synopsis
- Parkinson's disease is increasingly straining global healthcare, making it crucial to understand molecular mechanisms to create effective treatments.* ! -
- The AKT and ERK pathways are vital for neuronal survival and interact with multiple signaling pathways, presenting a complex network that complicates treatment approaches.* ! -
- This review examines these pathways' roles in disease progression and neuronal dysfunction, suggesting therapeutic targets by highlighting their interactions with stress responses, inflammation, and other cellular processes.* !
Article Synopsis
- Epigenetics, particularly histone modifications like acetylation, plays a crucial role in understanding and treating neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s.
- Imbalances in enzymes like histone acetyltransferases (HATs) and histone deacetylases (HDACs) can negatively affect gene expression and neurophysiological functions.
- Recent therapeutic approaches focus on HDAC inhibitors that enhance acetylation levels, aiming to improve memory formation and neuronal plasticity, although concerns about their target specificity remain.
Oxidative stress and mitochondrial dysfunction are leading mechanisms that play a crucial role in the progression of Parkinson's disease (PD). shows a wide range of biological activities including immunomodulatory, antimicrobial, antioxidant, and anti-inflammatory properties. This study explored the neuroprotective activities of ethanolic extract (TCE) against Rotenone (ROT)-intoxicated Parkinsonian mice.
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- Autophagy is a process that helps cells digest damaged proteins and organelles, and it may protect against Parkinson's disease by clearing misfolded proteins like α-synuclein from neurons.
- The study examined the effects of curcumin on Parkinson's disease in mice, focusing on its ability to activate autophagy and the Nrf2-Keap1 pathway, which is involved in cellular defense mechanisms.
- Results showed that curcumin improved motor skills, anti-oxidative activity, and mitochondrial function in mice, while also enhancing autophagy and normalizing the Nrf2-Keap1 pathway, suggesting curcumin's potential as a therapeutic agent for Parkinson's disease.
Article Synopsis
- Parkinson's disease (PD) is characterized by increased oxidative stress, mitochondrial dysfunction, and the aggregation of α-synuclein, leading to the death of dopamine-producing neurons.
- Downregulation of neurotrophic factors like BDNF contributes to PD progression, and maintaining the balance of related signaling pathways could help delay the disease.
- Oleuropein (OLE), a compound from olive leaves, shows potential as a neuroprotective treatment in PD by improving motor function and regulating key signaling proteins in a mouse model induced by the insecticide rotenone.
The medicinal plant Mucuna pruriens (Fabaceae) is widely known for its anti-oxidative and anti-inflammatory properties. It is a well-established drug in Ayurveda and has been widely used for the treatment of neurological disorders and male infertility for ages. The seeds of the plant have potent medicinal value and its extract has been tested in different models of neurodegenerative diseases, especially Parkinson's disease (PD).
View Article and Find Full Text PDFEndophytes either be bacteria, fungi, or actinomycetes colonize inside the tissue of host plants without showing any immediate negative effects on them. Among numerous natural alternative sources, fungal endophytes produce a wide range of structurally diverse bioactive metabolites including anticancer compounds. Considering the production of bioactive compounds in low quantity, genetic and physicochemical modification of the fungal endophytes is performed for the enhanced production of bioactive compounds.
View Article and Find Full Text PDFOroxylum indicum (L.) Kurz, a medicinal plant, shows numerous pharmacological properties which may be attributed to the bioactive compounds produced by O. indicum or due to associated endophytes.
View Article and Find Full Text PDFStress-induced dopaminergic (DAergic) neuronal death in the midbrain region is the primary cause of Parkinson's disease (PD). Following the discovery of l-dopa, multiple drugs have been developed to improve the lifestyle of PD patients; however, none have been suitable for clinical use due to their multiple side effects. has been used in traditional medicines to treat neurodegenerative diseases.
View Article and Find Full Text PDFIn the recent past, huge emphasis has been given to the epigenetic alterations of the genes responsible for the cause of neurological disorders. Earlier, the scientists believed somatic changes and modifications in the genetic makeup of DNA to be the main cause of the neurodegenerative diseases. With the increase in understanding of the neural network and associated diseases, it was observed that alterations in the gene expression were not always originated by the change in the genetic sequence.
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