Zhongguo Ying Yong Sheng Li Xue Za Zhi
October 2024
Ocular drug delivery presents a unique set of challenges owing to the complex anatomy and physiology of the eye. Processed excipients have emerged as crucial components in overcoming these challenges and improving the efficacy and safety of ocular drug delivery systems. This comprehensive overview examines the opportunities that processed excipients offer in enhancing drug delivery to the eye.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
June 2023
Mitochondria serve as critical producers of both cellular energy and metabolic precursors for biosynthesis required for organismal growth, activity, somatic maintenance, and reproduction. Consequently, variation in mitochondrial function is commonly associated with variation in life histories both within and across species. For instance, flight-capable, long-winged crickets have mitochondria with larger bioenergetic capacities than flightless, short-winged crickets investing in early lifetime fecundity instead of flight.
View Article and Find Full Text PDFBackground In this study, we aimed to determine the effects of storage time and temperature on commonly performed coagulation tests such as prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (APTT) in human plasma. Methodology Whole blood samples from 100 patients were collected in a 3.2% sodium citrate vacutainer.
View Article and Find Full Text PDFObjectives: H. Wolff is a rare medicinal plant characteristically used by the traditional healers in traditional medicine for the treatment of throat-pain, toothache, and stomach ache. The study was designed to determine the anthelmintic and analgesic properties of the aerial parts of H.
View Article and Find Full Text PDFBackground: The negative perception of parents toward invasive dental procedures has always created a barrier in delivering successful treatment to pediatric patients. Surprisingly, little is known about the perspective of parents and the impact of demographic and psychological factors guiding their decision.
Aim: To evaluate the acceptability of phlebotomy for obtaining platelet-rich fibrin (PRF) to be used in pediatric endodontic procedures among parents of children.
Indian J Thorac Cardiovasc Surg
January 2019
Thymolipoma is a rarely seen benign pathological entity of anterior mediastinum and constitutes of around 2-7% of thymic tumors. They usually present as soft tissue mass composed of mature adipose tissue and thymic tissue, which are clinically silent most of the time, i.e.
View Article and Find Full Text PDFRecent Pat Antiinfect Drug Discov
July 2018
Background: The nanoemulsion based carriers are the most suitable delivery systems for poorly soluble drugs to improve the drugs solubility, permeation of drugs and ultimately increase bioavailability by transdermal therapeutic system. The nanoemulsion for poorly soluble drugs is admirable and offered several advantages over others drug delivery.
Methods: For nanoemulsions formulation, they have to deliver the energetic element at the specific organ with nominal uneasiness.
Imbalance of zinc ion (Zn(2+)) in human body causes diseases like Alzheimer's and Parkinson's and therefore Zn(2+) estimation in biological fluids has diagnostic values. Fluorescence "off-on" sensors have advantages of high sensitivity and in situ application over other sensors. A new fluorescent "off-on" Zn(2+) sensor, N-benzoate-N' salicylaldehyde ethynelediamine (L), has been synthesisied.
View Article and Find Full Text PDFThe fluorescence intensity of salicylaldehyde phenylhydrazone (L), in 1:1 (v/v) CH3OH:H2O was enhanced by ca. 100 times with a blue shift in emission maximum, on interaction with Pb(2+) ion. No enhancement in fluorescent intensity of L was observed on interaction with metal ions - Na(+), K(+), Ca(2+), Cu(2+), Ni(2+), Zn(2+), Cd(2+) and Hg(2+).
View Article and Find Full Text PDFN,N,N,N-tetradentate macrocyclic ligand (L) has been synthesized by the condensation of benzil and semicarbazide and characterized. On excitation by light of wavelength 350 nm, L exhibited a fluorescent peak at λ(max) = 454 nm, which showed ca 6 times enhancement in intensity with a blue shift on interaction with Zn(2+). L has been found to act as a selective fluorescent sensor for zinc(2+) ion over a host of other metal ions such as- Cd(2+), Pb(2+), Hg(2+), Ca(2+), Fe(2+), Na(2+), Co(2+), Mn(2+), Cu(2+) and Ni(2+), in 1:1 CH(3)OH:H(2)O.
View Article and Find Full Text PDFCondensation product (L) of salicylaldehyde and semicarbazide behaves as a fluorescent sensor for Cd(2+) ion, in 1:1 DMSO:H(2)O, over Mn(2+), Fe(2+), Ni(2+), Co(2+), Cu(2+), Pb(2+) and Hg(2+) ions. The emission peak of L at λ(max) = 520 nm, on excitation with 420 nm wavelength photons, showed an enhancement in intensity of ca 60-fold when interacted with Cd(2+) ion. The intensity was however found to remain unaltered when interacted with metal ions--Mn(2+), Fe(2+), Ni(2+), Co(2+), Cu(2+), Pb(2+) and Hg(2+).
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