Publications by authors named "Priyanka G Gupta"
Mapping Tumor-Stroma-ECM Interactions in Spatially Advanced 3D Models of Pancreatic Cancer.
ACS Appl Mater Interfaces
March 2025
Article Synopsis
- Bioengineering tumor models offer valuable insights into cancer progression and therapy response, particularly for complex cancers like pancreatic ductal adenocarcinoma (PDAC).
- A systematic study using polyurethane scaffolds revealed how various extracellular matrix (ECM) protein coatings influence the behavior of cancer and stroma cells, affecting factors like cell aggregation and biomarker expression.
- The dual/zonal scaffold model mimicking PDAC microenvironments showed increased aggressiveness in cancer-stroma interactions compared to single scaffold systems, emphasizing the need to consider spatial complexity in cancer research.