Antibacterial efficacy of carnosic acid as an intracanal medicament against : Quantitative polymerase chain reaction study.

Aim: The aim of this study was to quantitatively assess the antibacterial effectiveness of carnosic acid, propolis, and calcium hydroxide when used as intracanal medications against .

Methodology: Forty-six human mandibular single-rooted premolar root lengths were standardized to 12 mm after decoronation. Cleaning and shaping were performed.

Molecular Mechanisms of Anticancer Activity of Stevioside in Human Osteosarcoma Cell Lines (Sarcoma Osteogenic).

Introduction: Osteosarcoma (OS) is a rare and aggressive form of bone cancer that primarily affects the long bones of the body, such as the arms and legs. It is characterized by the uncontrolled growth of malignant cells in the bone tissue, leading to the formation of abnormal and painful bone masses. glycosides have been widely used as natural noncalorie sweeteners and are the collective name of the sweet substances found naturally in the plant , which is commonly called .

A Decade-Long Retrospective Clinicopathological Study of Appendiceal Neoplasms.

Introduction:  Appendiceal neoplasms (ANs) are uncommon, representing less than 1% of all gastrointestinal tumors. They are most often discovered incidentally during appendectomies performed for suspected acute appendicitis. Recent studies have reported an increase in the incidence of AN.

Immunophenotypic Characteristics and Cytogenetic Analysis of Adolescent and Young Adult B-Cell Acute Lymphoblastic Leukemia: Correlations With Clinicopathological Parameters.

Introduction Acute lymphoblastic leukemia (ALL) has suboptimal survival rates for adolescents and young adults (AYA) as compared to children. Very limited studies have been conducted on AYA patients in India. This study aimed to identify the cytogenetic and immunophenotype characteristics of B-cell ALL (B-ALL) in AYA patients and determine its correlation with clinicopathological parameters in the Southern India region.

Evaluation of Cardiospermum halicacabum on Bone Morphogenetic Protein-2 (BMP2) mRNA Expression in Osteoblast Cells.

Introduction Maintaining bone health is crucial for overall well-being, with osteoblasts playing a vital role in bone formation. Bone morphogenetic protein-2 (BMP2) is a key regulator, stimulating bone matrix synthesis and osteoblast differentiation. Recognizing BMP2's significance, there's growing interest in natural compounds, such as .

Optimizing Antibiotic Treatment for Diabetic Foot Infections: A Study From a Tertiary Public Healthcare Center in Puducherry, South India.

Background: Diabetic foot infections (DFIs) represent a significant complication of diabetes mellitus, contributing to increased morbidity and mortality. Understanding antibiotic prescribing patterns and microbial susceptibility is crucial for effective management.

Objective: This study aimed to assess antibiotic prescribing trends and microbial susceptibility patterns in DFIs in a tertiary care center in Puducherry.

Evaluating Tumor Necrosis Factor (TNF)-Alpha Pro-inflammatory Cytokines in Healthy and Oral Squamous Cell Carcinoma Patients With and Without Diabetes.

Background Tumor necrosis factor-alpha (TNF-α) has a pivotal role in the pathogenesis and prognosis of cancer as well as diabetes mellitus (DM). Many oral squamous cell carcinoma (OSCC) patients are reported to have associated comorbidities such as type 2 diabetes mellitus (T2DM). Furthermore, T2DM exaggerates inflammation due to a lack of insulin action.

The Association of miRNA10a and Glucose Transporters in Oral Squamous Cell Carcinoma With Diabetes: A Pilot Study.

Introduction: MicroRNAs (miRNAs) are well-established post-translational non-coding RNAs that play crucial roles in mRNA degradation and repression. Glucose transporter 1 (GLUT1) showed correlation along with various miRNA, specifically miRNA10a expression in lung cancers. The role of miRNA10a along with glucose upregulation leading to cancer proliferation in oral squamous cell carcinoma (OSCC) is unknown.

miRNA Associated With Glucose Transporters in Oral Squamous Cell Carcinoma: A Systematic Review.

Oral squamous cell carcinoma (OSCC) is a malignancy of the oral cavity with poor prognosis. Dysregulation in glycolytic pathways involving glucose transporters (GLUT) has been implicated in poor prognosis. Furthermore, GLUT expression in cancer cells is regulated by several miRNAs.

Flagellin, a plant-defense-activating protein identified from Xanthomonas axonopodis pv. Dieffenbachiae invokes defense response in tobacco.

Background: Secretome analysis is a valuable tool to study host-pathogen protein interactions and to identify new proteins that are important for plant health. Microbial signatures elicit defense responses in plants, and by that, the plant immune system gets triggered prior to pathogen infection. Functional properties of secretory proteins from Xanthomonas axonopodis pv.

Multi-spectroscopic and molecular simulation methods of analysis to explore the mode of binding of Mebendazole drug with calf-thymus DNA.

UV-vis, fluorescence, circular dichroism (CD) and H NMR spectroscopic techniques have been employed to explore the mode of binding of Mebendazole (MBZ) drug with calf thymus DNA (CT-DNA). UV-vis and fluorescence spectral studies suggested a complex formation between the drug and nucleic acid. The fluorescence of MBZ was found to enhance upon binding with CT-DNA through a ground state complex formation with K in the order of 10 M.

DravidianCodeMix: sentiment analysis and offensive language identification dataset for Dravidian languages in code-mixed text.

This paper describes the development of a multilingual, manually annotated dataset for three under-resourced Dravidian languages generated from social media comments. The dataset was annotated for sentiment analysis and offensive language identification for a total of more than 60,000 YouTube comments. The dataset consists of around 44,000 comments in Tamil-English, around 7000 comments in Kannada-English, and around 20,000 comments in Malayalam-English.

Multi-spectroscopic and free energy landscape analysis on the binding of antiviral drug remdesivir with calf thymus DNA.

Remdesivir (REM) is an antiviral drug, which exercises its effect by targeting specifically RNA-dependent RNA polymerase. The interaction of REM with calf thymus DNA (CT-DNA) was investigated by multi-spectroscopic techniques (UV-Vis, fluorescence, circular dichroism and P NMR) in combination with different biophysical experiments and metadynamics simulation studies. UV-Vis and fluorescence spectroscopic analysis indicated formation of a complex between REM and CT-DNA, whose binding constant is in the order of 10 M.

Glycosyl hydrolase 11 (xynA) gene with xylanase activity from thermophilic bacteria isolated from thermal springs.

Background: Hemicellulose is one of the copious polymer in lignocellulosic biomass (LCB). It is primarily composed of xylan linked by β-1,4 glycosidic bonds. Xylanase preferentially cleaves the β-1,4-glycosidic bonds in the xylan backbone resulting in complete hydrolysis of the biomass.

A family of familial gigantiform cementoma: clinical study.

Background: Familial gigantiform cementoma is an autosomal dominant fibro-cement osseous lesion that causes massive expansion of facial skeleton. Patients with such massive lesions have a compromised quality of life. The main goal of treating such patients is to restore and preserve the jaw as far as possible which would enhance their quality of life.

Level of Resilience Among Transgenders in Selected Areas of Puducherry, India: An Exploratory Research.

Background Resilience is the process of adapting well in the face of adversity, trauma, tragedy, threats, or significant sources of stress, and it is a predictor of mental health status that specifically indicates self-esteem, perceived social support, emotion-oriented coping, and a sense of personal mastery. The third gender known better as transgender has existed in every culture, race, class, and religion since the inception of human life has been recorded and analyzed. In spite of many advances and reforms, the current plight of transgender is far from being satisfactory.

A Community-Based Cross-Sectional Study about the Quality of Life in Postmenopausal Women in Rural Puducherry.

Background: The aim of this study was to assess the quality of life (QOL) of postmenopausal women, in the rural areas of Puducherry and to find the associated factors.

Materials And Methods: A cross-sectional study was done in the rural field practicing area of SLIMS, Puducherry. The sample size was 172 based on the previous study, and simple random sampling technique was used.

Spectrum of features in Darier's disease: A case report with emphasis on differential diagnosis.

Oral genodermatoses includes a spectrum of inherited dermatological disorders with varying oral mucosal manifestations. Darier's disease is an autosomal dominant disorder with defect in desmosomal attachment. This case report presents oro cutaneous manifestations of Darier's disease in a 40 year old female patient with a detailed review on etiology, pathogenesis, differential diagnosis and management of the condition.

Association of OLP and thyroid disorder: Case report and review of literature.

Oral lichen planus is a chronic T cell mediated inflammatory condition with multifactorial etiology. Being autoimmune mediated condition, it has been associated with other autoimmune disorders. This case report discusses the possible presentation of oral lichen planus in hypothyroid patients as a marker of severity of the thyroid deficient status and the possible pathogenetic link between both the conditions.

Evaluation of antitumor and antioxidant activity of Sargassum tenerrimum against Ehrlich ascites carcinoma in mice.

Context: In the last half century, discovering, developing and introducing of clinical agents from marine sources have seen great successes, with examples including the anti-cancer compound trabectedin. However, with increasing need for new anticancer drugs, further exploration for novel compounds from marine organism sources is strongly justified.

Objective: The major aim of this study was to evaluate the antitumor and antioxidant potential of Sargassum tenerrimum J.

Microwave-mediated extracellular synthesis of metallic silver and zinc oxide nanoparticles using macro-algae (Gracilaria edulis) extracts and its anticancer activity against human PC3 cell lines.

A rapid and novel microwave-mediated protocol was established for extracellular synthesis of metallic silver (Ag) and zinc oxide (ZnO) nanoparticles using the extracts of macro-algae Gracilaria edulis (GE) and also examined its anticancer activity against human prostate cancer cell lines (PC3). The formation of silver nanoparticles (GEAgNPs) and zinc oxide nanoparticles (GEZnONPs) in the reaction mixture was determined by ultraviolet-visible spectroscopy. The synthesized Ag and ZnO nanoparticles were characterized by X-ray diffraction, Fourier transform infra-red spectroscopy, energy dispersive X-ray, and field emission scanning electron microscopy.

Repeated Random Mutagenesis of alpha-Amylase from Bacillus licheniformis for Improved pH Performance.

The alpha-amylases activity was improved by random mutagenesis and screening. A region comprising residues from the position 34-281 was randomly mutated in B. licheniformis alpha-amylase (AmyL), and the library with mutations ranging from low, medium, and high frequencies was generated.

Role of Val289 residue in the alpha-amylase of Bacillus amyloliquefaciens MTCC 610: an analysis by site directed mutagenesis.

The Val289 residue in the alpha-amylase of Bacillus amyloliquefaciens, which is equivalent to the Ala289 and Val286 residues in the alpha-amylases of B. stearothermophilus and B. licheniformis, respectively, was studied by site-directed mutagenesis.

Quantitative digital image analysis of chromogenic assays for high throughput screening of alpha-amylase mutant libraries.

An image analysis-based method for high throughput screening of an alpha-amylase mutant library using chromogenic assays was developed. Assays were performed in microplates and high resolution images of the assay plates were read using the Virtual Microplate Reader (VMR) script to quantify the concentration of the chromogen. This method is fast and sensitive in quantifying 0.