Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis.

E26 transformation specific (ETS) family transcription factors are expressed during embryogenesis and are involved in various cellular processes such as proliferation, migration, differentiation, angiogenesis, apoptosis, and survival of cellular lineages to ensure appropriate development. Dysregulated expression of many of the ETS family members is detected in different cancers. The human ELF3, a member of the ETS family of transcription factors, plays a role in the induction and progression of human cancers is well studied.

Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish.

Fetal alcohol spectrum disorder (FASD) results from prenatal ethanol exposure. The zebrafish () is an outstanding in vivo FASD model. Early development produced the three germ layers and embryonic axes patterning.